Journal ArticleDOI
Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma.
Eleanor M. Minshall,Donald Y.M. Leung,Richard J. Martin,Yan Ling Song,Lisa Cameron,Pierre Ernst,Qutayba Hamid +6 more
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TLDR
Evidence is provided that TGF-beta1 may play a role in the fibrotic changes occurring within asthmatic airways and that activated eosinophils are a major source of this cytokine.Abstract:
The histopathology of bronchial asthma is associated with structural changes within the airways, including subepithelial fibrosis, as well as chronic eosinophilic inflammation. The mechanisms responsible for this tissue remodeling, and in particular the role of inflammatory cells, remain to be established. Transforming growth factor-β (TGF-β) is a potent profibrotic cytokine which may contribute to the thickening of the reticular lamina by the deposition of collagen fibers. To investigate the molecular mechanisms underlying these structural changes, we have investigated the expression of TGF-β1 mRNA and immunoreactivity within the bronchial mucosa of mild to severe asthmatic individuals and normal control subjects using the techniques of in situ hybridization and immunocytochemistry. As eosinophils are prominent within the asthmatic airway and are known to synthesize pro-inflammatory cytokines, the presence of TGF-β1 mRNA and immunoreactive protein in eosinophils was also examined. Asthmatic individuals e...read more
Citations
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Mechanisms of fibrosis: therapeutic translation for fibrotic disease
TL;DR: How cell-intrinsic changes in important structural cells can perpetuate the fibrotic response by regulating the differentiation, recruitment, proliferation and activation of extracellular matrix–producing myofibroblasts is described.
Journal ArticleDOI
Asthma. From bronchoconstriction to airways inflammation and remodeling.
TL;DR: This work has shown that chronic inflammation in the different forms of Asthma can affect both the severity and duration of the symptoms of the disease and the treatment options for these conditions vary greatly.
Journal ArticleDOI
Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics
Sally E. Wenzel,Lawrence B. Schwartz,Esther L. Langmack,Janet L. Halliday,John B. Trudeau,Robyn L. Gibbs,Hong Wei Chu +6 more
TL;DR: The results suggest that two distinct pathologic, physiologic, and clinical subtypes of severe asthma exist, with implications for further research and treatment.
Journal ArticleDOI
IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines.
Sophie Molet,Qutayba Hamid,Francis Davoine,Esra Nutku,Rame Taha,Nathalie Pagé,Ron Olivenstein,Jack A. Elias,Jamila Chakir +8 more
TL;DR: The results, which demonstrate for the first time that eosinophils are a potential source of IL-17 within asthmatic airways, suggest that IL- 17 might have the potential to amplify inflammatory responses through the release of proinflammatory mediators such as alpha-chemokines.
Journal ArticleDOI
Remodeling in Asthma and Chronic Obstructive Lung Disease
TL;DR: In asthma several of these structural alterations begin early in the disease process, even in the child, and later in life and the associated inflammatory response differs from that in asthma.
References
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Journal ArticleDOI
Transforming growth factor type beta induces monocyte chemotaxis and growth factor production
Sharon M. Wahl,Denise A. Hunt,Lalage M. Wakefield,Nancy McCartney-Francis,Larry M. Wahl,Anita B. Roberts,Michael B. Sporn +6 more
TL;DR: It is demonstrated that TGF-beta is a potent chemoattractant for human peripheral blood monocytes and may provide an important signal for monocyte recruitment and for regulation of their synthesis of mediators of fibroblast growth and activity in wound healing.
Journal ArticleDOI
Subepithelial fibrosis in the bronchi of asthmatics
TL;DR: Findings contradict the long-held notion of basement membrane thickening in asthma and indicate that the subepithelial fibrosis is a result of fibroblast activation rather than bronchial epithelial cell dysfunction.
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Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity.
TL;DR: The light and electron microscopic structure of lobar bronchial biopsies taken at fiberoptic bronchoscopy from 11 atopic asthmatics, four of which were symptomatic and seven of whom were asymptomatic, was studied to study the structural changes in mild asthma.
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The pathology of asthma, with special reference to changes in the bronchial mucosa
TL;DR: It is postulated that bronchospasm plays little or no part in the shedding of the bronchial mucosa or in the pathogenesis of the asthmatic attack.
Journal ArticleDOI
Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma.
May Azzawi,B. Bradley,Peter K. Jeffery,Anthony J. Frew,Andrew J. Wardlaw,Knowles G,B. Assoufi,J.V. Collins,Stephen R. Durham,A. B. Kay +9 more
TL;DR: Examination of mucosal biopsies obtained from both central and subsegmental bronchi showed that the highest number of CD45-, DC3-, DC4-, and CD8-positive cells were found in the group with asthma, and there was a significant increase in the number of interleukin-2 receptor (CD25)-positive cells.