Journal ArticleDOI
Epidemiology of multiple sclerosis
TLDR
Analysis of highly informative populations, such as discordant identical twins and adoptive siblings of MS patients, likely will improve the specificity of case-control studies by minimizing the vast number of potential differences between cases and controls.About:
This article is published in Neurologic Clinics.The article was published on 1996-05-01. It has received 798 citations till now. The article focuses on the topics: Population Risk & Population.read more
Citations
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Journal ArticleDOI
Axonal transection in the lesions of multiple sclerosis.
TL;DR: Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
Journal ArticleDOI
Immunology of multiple sclerosis
Mireia Sospedra,Roland Martin +1 more
TL;DR: In the early stages of MS, the activation of CD4+ autoreactive T cells and their differentiation into a Th1 phenotype are a crucial events in the initial steps, and these cells are probably also important players in the long-term evolution of the disease.
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The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Bruce D. Trapp,Klaus-Armin Nave +1 more
TL;DR: Data that support neurodegeneration as the major cause of irreversible neurological disability in MS patients are reviewed and it is questioned whether inflammatory demyelination is primary or secondary in the disease process.
Journal ArticleDOI
Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
TL;DR: In this paper, structural similarity between viral T cell epitopes and self-peptides could lead to the induction of an autoaggressive T cell response based on the structural requirements for both MHC class 11 binding and TCR recognition of an immunodominant myelin basic protein (MBP) peptide.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal Article
Linkage strategies for genetically complex traits. I. Multilocus models.
TL;DR: It is shown in the second paper of this series that lambda R is the critical parameter in determining power to detect linkage by using affected relative pairs in multilocus models of inheritance.
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A genetic basis for familial aggregation in multiple sclerosis
TL;DR: Findings indicate that familial aggregation of MS is genetically determined: no effect of shared environment was detectable and the frequency of MS among first-degree non-biological relatives living with the index case was no greater than expected from Canadian population prevalence data and significantly less than for biological relatives.
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Clinical viral infections and multiple sclerosis
TL;DR: Frequency of common infections was approximately 20-50% less in MS patients than controls; it was progressively less in those with greater disability, suggesting that MS patients could have superior immune defences against common viruses.
Journal ArticleDOI
Hla class ii-associated genetic susceptibility in multiple sclerosis : a critical evaluation
Olle Olerup,Jan Hillert +1 more
TL;DR: These issues were investigated in a large group of Swedish MS patients and it was found that the associations with the suggested DQB1 sequences and position 34 of the DQ alpha chain were due to linkage disequilibrium and secondary to the association with the DRw15,DQw6,Dw2 haplotype.