Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice.
Francesco Matrisciano,Patricia Tueting,Ishani Dalal,Bashkim Kadriu,Dennis R. Grayson,John M. Davis,Ferdinando Nicoletti,Alessandro Guidotti +7 more
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TLDR
Preliminary data show that prenatal stress in mice induces abnormalities in the DNA methylation network and in behaviors indicative of a schizophrenia-like phenotype, and PRS mice may be a valid model for the investigation of new drugs for schizophrenia treatment targetingDNA methylation.About:
This article is published in Neuropharmacology.The article was published on 2013-05-01 and is currently open access. It has received 240 citations till now. The article focuses on the topics: Reelin & Prenatal stress.read more
Citations
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Book ChapterDOI
Histone and DNA Methylome in Neurodegenerative, Neuropsychiatric and Neurodevelopmental Disorders
TL;DR: This review focusses on the changes in epigenetic machinery, specifically on the histone methylation and DNA methylation patterns during the onset and progression of neurodegenerative diseases and neuropsychiatric disorders.
Journal ArticleDOI
Epigenetic regulation in the neurogenic niche of the adult dentate gyrus.
TL;DR: In this paper, the authors review recent advances of epigenetic regulation in aNSPC and their surrounding niche cells within the adult dentate gyrus (DG) of the hippocampal formation.
Gene-environment interplay of extreme anxiety-related behavior: implications for corticotropin-releasing hormone receptor 1
TL;DR: This document summarizes current capabilities, research and operational priorities, and plans for further studies that were established at the 2015 USGS workshop on quantitative hazard assessments of earthquake-triggered landsliding and liquefaction in the Central American region.
Dissertation
Epigenetic consequences of early-life caregiver maltreatment in rat medial prefrontal cortex neurons
References
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Journal ArticleDOI
Cortical inhibitory neurons and schizophrenia
TL;DR: Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia.
Journal ArticleDOI
The Developmental Origins of Adult Disease
TL;DR: It is shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth, and a new vision of optimal early human development is emerging which takes account of both short and long-term outcomes.
Journal ArticleDOI
Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse.
Nobuaki Tamamaki,Yuchio Yanagawa,Ryohei Tomioka,Jun-ichi Miyazaki,Kunihiko Obata,Takeshi Kaneko +5 more
TL;DR: A map of GFP distribution in the knock‐in mouse brain is constructed and many medium‐sized spherical somata emitting intense GFP fluorescence were observed in layer I, in accord with unidentified GFP‐positive cells.
Journal ArticleDOI
Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: A postmortem brain study
Alessandro Guidotti,James Auta,John M. Davis,Valeria DiGiorgi Gerevini,Yogesh Dwivedi,Dennis R. Grayson,Francesco Impagnatiello,Ghanshyam N. Pandey,Christine Pesold,Rajiv P. Sharma,D.P. Uzunov,Erminio Costa +11 more
TL;DR: The selective down-regulation of RELN and GAD(67) in prefrontal cortex of patients with schizophrenia and bipolar disorder who have psychosis is consistent with the hypothesis that these parameters are vulnerability factors in psychosis; this plus the loss of the correlation between these 2 parameters that exists in nonpsychotic subjects support the hypotheses that these changes may be liability factors underlying psychosis.
Journal ArticleDOI
Dynamic DNA methylation programs persistent adverse effects of early-life stress
Chris Murgatroyd,Alexandre V. Patchev,Yonghe Wu,Vincenzo Micale,Yvonne Bockmühl,Dieter Fischer,Florian Holsboer,Carsten T. Wotjak,Osborne F. X. Almeida,Dietmar Spengler +9 more
TL;DR: It is found that neuronal activity controlled the ability of MeCP2 to regulate activity-dependent transcription of the Avp gene and induced epigenetic marking, which can dynamically control DNA methylation in postmitotic neurons to generate stable changes in Avp expression that trigger neuroendocrine and behavioral alterations that are frequent features in depression.
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Sex-specific programming of offspring emotionality after stress early in pregnancy.
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