Journal ArticleDOI
Epigenetic signature of MAOA and MAOB genes in mental disorders.
TLDR
First evidence for MAOA methylation to be involved in treatment response prediction and as a potential mechanistic correlate of fear extinction is presented, and altered MAOA gene DNA methylation emerges as a possible pathogenetically relevant epigenetic mechanism in mental disorders.Abstract:
Epigenetic processes such as DNA methylation are considered key mechanisms at the crossroads between genetics and environment in the etiology of mental disorders. The monoamine oxidases A and B (MAOA/MAOB) are prime candidates for the investigation into the role of DNA methylation in mental disorders, given their pivotal role in the metabolism of monoamines and as pharmacological targets of potent antidepressant drugs such as tranylcypromine, phenelzine or moclobemide. The present mini-review aims at summarizing and critically discussing the growing body of the literature supporting a role of DNA methylation of the MAOA gene promoter/exon I/intron I region and its interaction with environmental factors in several mental disorders, i.e., anxiety disorders, depression, posttraumatic stress disorder, substance use disorder, conduct disorder/antisocial personality disorder, borderline personality disorder and schizophrenia, as well as some pilot data on MAOB methylation in smokers and patients with borderline personality disorder. Furthermore, first evidence for MAOA methylation to be involved in treatment response prediction and as a potential mechanistic correlate of fear extinction is presented. Altered MAOA gene DNA methylation emerges as a possible pathogenetically relevant epigenetic mechanism in mental disorders. Given robust replication and further functional characterization, MAOA methylation patterns might serve as a peripheral biomarker of disease risk and treatment response informing preventive and personalized therapeutic approaches in the future.read more
Citations
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Journal ArticleDOI
The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention.
TL;DR: Given first evidence pointing to a transgenerational transmission of epigenetic information, epigenetic alterations arising from successful psychotherapy might be transferred to future generations and thus contribute to the prevention of mental disorders.
Journal ArticleDOI
Monoamine Oxidase A Hypomethylation in Obsessive-Compulsive Disorder: Reversibility By Successful Psychotherapy?
Miriam A. Schiele,Christiane Thiel,Jürgen Deckert,Michael Zaudig,Götz Berberich,Katharina Domschke +5 more
TL;DR: The present pilot data suggest MAOA hypomethylation as a potential risk marker of obsessive-compulsive disorder and an increase in MAOA methylation levels as a possible mechanistic correlate of response to cognitive behavioral therapy in obsessive-Compulsive disorder.
Journal ArticleDOI
The DNA methylome in panic disorder: a case-control and longitudinal psychotherapy-epigenetic study
Christiane Ziegler,Franziska Grundner-Culemann,Miriam A. Schiele,Pascal Schlosser,Leonie Kollert,Marina Mahr,Agnieszka Gajewska,Klaus-Peter Lesch,Klaus-Peter Lesch,Klaus-Peter Lesch,Jürgen Deckert,Anna Köttgen,Katharina Domschke +12 more
TL;DR: These EWAS and first longitudinal epigenome-wide pilot data in PD add to the emerging candidate gene-based body of evidence for epigenetic mechanisms to be involved in PD pathogenesis and to possibly constitute dynamic biological correlates of therapeutic interventions.
Journal ArticleDOI
An integrative metabolomics and network pharmacology method for exploring the effect and mechanism of Radix Bupleuri and Radix Paeoniae Alba on anti-depression.
Hongcai Zhang,Shuxiang Zhang,Mingxu Hu,Yanyan Chen,Wang Wenran,Ke Zhang,Hai-Xue Kuang,Qiuhong Wang,Qiuhong Wang +8 more
TL;DR: Analysis of metabolomics results showed that the Radix Bupleuri and Radix Paeoniae Alba drug pair can significantly improve CUMS-induced depression and the underlying mechanism of its antidepressant effect involves regulating the expression of brain-derived neurotrophic factors, inhibiting neurotoxicity, and regulating the HPA axis.
Journal ArticleDOI
Twin study designs as a tool to identify new candidate genes for depression: A systematic review of DNA methylation studies.
TL;DR: This review systematically evaluate all twin studies published to date assessing DNA methylation in association with depressive phenotypes, finding that difficulty to recruit large numbers of MZ twin pairs fails to provide enough sample size to develop genome-wide approaches.
References
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Journal ArticleDOI
X-inactivation profile reveals extensive variability in X-linked gene expression in females
TL;DR: A comprehensive X-inactivation profile of the human X chromosome is presented, representing an estimated 95% of assayable genes in fibroblast-based test systems, and suggests a remarkable and previously unsuspected degree of expression heterogeneity among females.
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A longitudinal study of epigenetic variation in twins
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TL;DR: The data suggest that DNA methylation differences are apparent already in early childhood, even between genetically identical individuals, and that individual differences in methylation are not stable over time.
Journal ArticleDOI
Quantitative DNA methylation analysis based on four-dye trace data from direct sequencing of PCR amplificates
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Christiane Ziegler,Jan Richter,Marina Mahr,Agnieszka Gajewska,Miriam A. Schiele,Andrea Gehrmann,Boris Schmidt,Klaus-Peter Lesch,Thomas Lang,Thomas Lang,Sylvia Helbig-Lang,Sylvia Helbig-Lang,Paul Pauli,Tilo Kircher,Andreas Reif,Winfried Rief,Anna N. Vossbeck-Elsebusch,Volker Arolt,Hans-Ulrich Wittchen,Alfons O. Hamm,Juergen Deckert,Katharina Domschke +21 more