Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern.
Juanjie Tang,Youri Lee,Supriya Ravichandran,Gabrielle Grubbs,Chang Huang,Charles B. Stauft,Tony Wang,Basil Golding,Hana Golding,Surender Khurana +9 more
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TLDR
In this article, the authors explored the antibody epitope repertoire, and virus neutralizing capacity of six hCoV-2IG batches as well as nine convalescent plasma (CP) against SARS-CoV2 and emerging variants of concern (VOC).About:
This article is published in iScience.The article was published on 2021-08-20 and is currently open access. It has received 21 citations till now. The article focuses on the topics: Neutralization & Epitope.read more
Citations
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SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19.
Supriya Ravichandran,Juanjie Tang,Gabrielle Grubbs,Youri Lee,Sara Pourhashemi,Laila Hussaini,Stacey A. Lapp,Robert C. Jerris,Vidisha Singh,Ann Chahroudi,Evan J. Anderson,Christina A. Rostad,Surender Khurana +12 more
TL;DR: In this paper, SARS-CoV-2 proteome-wide immunoprofiling of children with mild/moderate or severe coronavirus disease 2019 (COVID-19) versus multisystem inflammatory syndrome in children versus hospitalized control patients revealed differential cytokine responses, IgM/IgG-IgA diversity, antibody binding and avidity.
Journal ArticleDOI
Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C
Juanjie Tang,Tanya Novak,Julian Hecker,Gabrielle Grubbs,Fatema Tuz Zahra,Lorenza Bellusci,Sara Pourhashemi,Janet Chou,Kristin Moffitt,Natasha B. Halasa,Stephanie P Schwartz,Tracie C. Walker,Keiko M. Tarquinio,Matt S. Zinter,Mary A. Staat,Shira J. Gertz,Natalie Z. Cvijanovich,Jennifer E. Schuster,Laura Loftis,Bria M. Coates,Elizabeth H. Mack,Katherine Irby,Julie C. Fitzgerald,Courtney M. Rowan,Michele Kong,Heidi R. Flori,Aline B Maddux,Steven L. Shein,Hillary Crandall,Janet R. Hume,Charlotte V. Hobbs,Adriana H. Tremoulet,Chisato Shimizu,Jane C. Burns,Sabrina R. Chen,Hye-Kyung Moon,Christoph Lange,Adrienne G. Randolph,Surender Khurana +38 more
TL;DR: In this paper , the authors evaluated the neutralization capacity of antibodies against Omicron after a prior SARS-CoV-2 infection in children and adolescents and found that less than 10% of the vaccinated patients showed neutralizing antibody titers against omicron.
Journal ArticleDOI
Therapeutic monoclonal antibodies for COVID-19 management: an update
Vivek P. Chavda,Riddhi Prajapati,Disha Lathigara,Bhumi Nagar,Jay Kukadiya,Elrashdy M. Redwan,Vladimir N. Uversky,Mukesh N. Kher,Patel Rajvi +8 more
TL;DR: This review article provides insights into the basic aspects of monoclonal antibodies for the therapy of COVID-19, as well as its advancement in terms of clinical trial and current approval status.
Journal ArticleDOI
Antibody affinity and cross-variant neutralization of SARS-CoV-2 Omicron BA.1, BA.2 and BA.3 following third mRNA vaccination
Lorenza Bellusci,Gabrielle Grubbs,Fatema Tuz Zahra,David Forgacs,Hana Golding,Ted M. Ross,Surender Khurana +6 more
TL;DR: In this article , the authors measured the durability of neutralization capacity and antibody affinity maturation generated following two versus three doses of SARS-CoV-2 mRNA vaccines in naïve versus convalescent individuals (hybrid immunity) against the highly transmissible Omicron BA.1, BA.2 and BA.3 subvariants.
Journal ArticleDOI
Passive Immunotherapy Against SARS-CoV-2: From Plasma-Based Therapy to Single Potent Antibodies in the Race to Stay Ahead of the Variants
TL;DR: More than three dozen antibodies or antibody combinations have been forwarded into clinical trials, including Eli Lilly's bamlanivimab and etesevimab, Regeneron's mixture of imdevimab with casirivimabs, Vir's sotrovimab (SOTV), Celltrion's regdanvimab, and Lilly's bebtelovimab as mentioned in this paper .
References
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Molecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2.
TL;DR: The authors determined the crystal structures of two antibodies, CC12.1 and CC 12.3, encoded by a common IGHV353 gene, but belonging to different clonotypes, in order to define the structural features, and to add favorable properties for RBD recognition to I GHV3-53, suggesting that SARSCoV, SARS-CoV-2, and MERS- coV are immunologically distinct.
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Flawed interferon response spurs severe illness.
TL;DR: It is revealed that in a significant minority—14%— of a large global sample of patients hospitalized with life-threatening COVID-19, the body's interferon response has been crippled by genetic flaws or by rogue antibodies that attackinterferon itself.
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Antigenic Fingerprinting of Respiratory Syncytial Virus (RSV)-A-Infected Hematopoietic Cell Transplant Recipients Reveals Importance of Mucosal Anti-RSV G Antibodies in Control of RSV Infection in Humans
Sandra Fuentes,Megan Hahn,Katarina Chilcote,Roy F. Chemaly,Dimpy P. Shah,Xunyan Ye,Vasanthi Avadhanula,Pedro A. Piedra,Hana Golding,Surender Khurana +9 more
TL;DR: A significantly higher antibody affinity to RSV-G was observed in nasal washes from early-Recovered individuals compared with late-recovered HCT patients, highlighting the importance of mucosal antibodies in resolution of RSV -A infection in the upper respiratory tract.
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Viral evolution may herald new pandemic phase.
TL;DR: For COVID-19 researchers, this year brings a strong sense of deja vu. As in early 2020, the world is anxiously watching a virus spread in one country and trying to parse the risk for others as discussed by the authors.
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Convalescent plasma and hyperimmune globulin therapy in COVID-19.
TL;DR: In this article, the authors reviewed randomized controlled studies using convalescent plasma therapy and hyperimmune globulins (HIG) for the treatment of severe acute respiratory syndrome causing coronavirus SARS-CoV-2 (coronavirus disease 2019 (COVID-19)) caused by the recent global pandemic.
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