Journal ArticleDOI
Epstein-Barr Virus Infection
TLDR
The Epstein–Barr virus (EBV) was discovered 36 years ago by electron microscopy of cells cultured from Burkitt's lymphoma tissue by Epstein, Achong, and Barr and has been found in tissues from other cancers, including T-cell lymphomas and Hodgkin's disease.Abstract:
The Epstein–Barr virus (EBV) was discovered 36 years ago by electron microscopy of cells cultured from Burkitt's lymphoma tissue by Epstein, Achong, and Barr.1 Four years later, in 1968, EBV was shown to be the etiologic agent of heterophile-positive infectious mononucleosis.2 EBV DNA was detected in tissues from patients with nasopharyngeal carcinoma in 1970.3 In the 1980s, EBV was found to be associated with non-Hodgkin's lymphoma and oral hairy leukoplakia in patients with the acquired immunodeficiency syndrome (AIDS).4,5 Since then, EBV DNA has been found in tissues from other cancers, including T-cell lymphomas and Hodgkin's disease.6,7 EBV is . . .read more
Citations
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Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
TL;DR: It is revealed that the intestinal microbiota profoundly impacts the balance between pro- and antiinflammatory immune responses during EAE and suggest that modulation of gut bacteria may provide therapeutic targets for extraintestinal inflammatory diseases such as MS.
Journal ArticleDOI
Environmental risk factors for multiple sclerosis. Part I: the role of infection.
TL;DR: It is shown that whereas EBV stands out as the only infectious agent that can explain many of the key features of MS epidemiology, by itself the link between EBV and MS cannot explain the decline in risk among migrants from high to low MS prevalence areas, which implies that either EBV strains in low‐risk areas have less propensity to cause MS, or that other infectious or noninfectious factors modify the host response to EBV or otherwise contribute to determine MS risk.
Journal ArticleDOI
Persistence of the Epstein–Barr Virus and the Origins of Associated Lymphomas
TL;DR: This review of the life cycle of the Epstein–Barr virus explains how EBV establishes lifelong infection in a host with protective immunity against the virus.
Journal ArticleDOI
Keratin expression in human tissues and neoplasms.
Peiguo G. Chu,Lawrence M. Weiss +1 more
TL;DR: In this article, the molecular and cell biology of Keratin filaments are reviewed and the expression patterns of these filaments in various human epithelial neoplasms are analyzed, including simple epithelia generally express the simple epithelial keratins 7, 18, 19, and 20, while complex epithelias express complex epithelial Keratins 5/6, 10, 14, and 15.
Journal ArticleDOI
Epstein-Barr Virus Antibodies and Risk of Multiple Sclerosis: A Prospective Study
Alberto Ascherio,Kassandra L. Munger,Evelyne T. Lennette,Donna Spiegelman,Miguel A. Hernán,Michael J. Olek,Susan E. Hankinson,David J. Hunter +7 more
TL;DR: The results support a role of EBV in the etiology of MS, and elevation in serum antibody titers to the specific EBV and CMV antigens, compared between cases and controls.
References
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Journal ArticleDOI
Virus particles in cultured lymphoblasts from burkitt's lymphoma.
M A Epstein,B G Achong,Y M Barr +2 more
Journal ArticleDOI
An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells
TL;DR: This is the first demonstration of a transforming gene in Epstein-Barr virus, a ubiquitous human pathogen associated with neoplasia, which is likely to account for many aspects of EBV induced cell transformations.
Journal ArticleDOI
EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx.
H. zur Hausen,Heinrich Schulte-Holthausen,George Klein,Werner Henle,Gertrude Henle,Peter Clifford,L Santesson +6 more
TL;DR: Epstein–Barr Virus in Burkitt's Lymphoma and Nasopharyngeal Carcinoma: EBV DNA in Biopsies of Burkitt Tumours and Anaplastic Carcinomas of the Nasopharyx is studied.
Journal ArticleDOI
Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI.
Kevin W. Moore,Paulo Vieira,David Fiorentino,Mary L. Trounstine,Tariq A. Khan,Tim R. Mosmann +5 more
TL;DR: The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.
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Persistence of the Epstein–Barr Virus and the Origins of Associated Lymphomas
Virus particles in cultured lymphoblasts from burkitt's lymphoma.
M A Epstein,B G Achong,Y M Barr +2 more