Esophageal Distensibility as a Measure of Disease Severity in Patients with Eosinophilic Esophagitis
Frédéric Nicodème,Frédéric Nicodème,Ikuo Hirano,Joan Chen,Kenika Robinson,Zhiyue Lin,Yinglian Xiao,Yinglian Xiao,Nirmala Gonsalves,Mary J. Kwasny,Peter J. Kahrilas,John E. Pandolfino +11 more
TLDR
Reduced esophageal distensibility predicts risk for food impaction and the requirement for esphageal dilation in patients with eosinophilic esophagitis and the severity of mucosal eOSinophilia was not predictive of these outcomes and had a poor correlation with esophagesibility.About:
This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2013-09-01 and is currently open access. It has received 225 citations till now. The article focuses on the topics: Eosinophilic esophagitis.read more
Citations
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Journal ArticleDOI
Functional Esophageal Disorders
TL;DR: Treatments directed at improving borderline motor dysfunction or reducing reflux burden to sub-normal levels have limited success in symptom improvement, and strategies focused on modulating peripheral triggering and central perception are mechanistically viable and clinically meaningful.
Journal ArticleDOI
A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease
Evan S. Dellon,Hannah P. Kim,Sarah L.W. Sperry,David A. Rybnicek,John T. Woosley,Nicholas J. Shaheen +5 more
TL;DR: In this large EoE cohort, the likelihood of fibrostenotic disease increased markedly with age, and this association suggests that the natural history of Eosinophilic esophagitis is a progression from an inflammatory to a fibrostanotic disease.
Journal ArticleDOI
Eosinophilic Esophagitis in Adults Is Associated With IgG4 and Not Mediated by IgE
Frederic Clayton,John C. Fang,Gerald J. Gleich,Alfredo J. Lucendo,José María Olalla,Laura A. Vinson,Amy Lowichik,Amy Lowichik,Xinjian Chen,Lyska Emerson,Kristen Cox,Molly O'Gorman,Molly O'Gorman,Kathryn A. Peterson +13 more
TL;DR: Findings indicate that, in adults, eosinophilic esophagitis is IgG4-associated, and not an IgE-induced allergy, and that omalizumab did not alter symptoms of eos inophilic Esophageal mucosal biopsy samples compared with placebo.
Journal ArticleDOI
Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis
Ikuo Hirano,Evan S. Dellon,Jennifer D. Hamilton,Margaret H. Collins,Kathryn A. Peterson,Mirna Chehade,Alain M. Schoepfer,Ekaterina Safroneeva,Marc E. Rothenberg,Gary W. Falk,Yehudith Assouline-Dayan,Qiong Zhao,Zhen Chen,Brian N. Swanson,Gianluca Pirozzi,Leda Mannent,Neil M.H. Graham,Bolanle Akinlade,Neil Stahl,George D. Yancopoulos,Allen Radin +20 more
TL;DR: In a phase 2 trial of patients with active EoE, dupilumab reduced dysphagia, histologic features of disease (including eosinophilic infiltration and a marker of type 2 inflammation), and abnormal endoscopic features, compared with placebo, and was generally well tolerated.
Journal ArticleDOI
Advances in clinical management of eosinophilic esophagitis.
TL;DR: The current diagnostic criteria and challenges to diagnosis are explained, including the role of gastroesophageal reflux disease and proton pump inhibitor-responsive esphageal eosinophilia, and the main treatment approaches and new treatment options are reviewed.
References
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Journal ArticleDOI
Eosinophilic esophagitis: Updated consensus recommendations for children and adults
Chris A. Liacouras,Glenn T. Furuta,Ikuo Hirano,Dan Atkins,Stephen Attwood,Peter A Bonis,A. Wesley Burks,Mirna Chehade,Margaret H. Collins,Evan S. Dellon,Ranjan Dohil,Gary W. Falk,Nirmala Gonsalves,Sandeep K. Gupta,David A. Katzka,Alfredo J. Lucendo,Jonathan E. Markowitz,Richard J. Noel,Robert D. Odze,Philip E. Putnam,Joel E. Richter,Yvonne Romero,Eduardo Ruchelli,Hugh A. Sampson,Alain M. Schoepfer,Nicholas J. Shaheen,Scott H. Sicherer,Stuart J. Spechler,Jonathan M. Spergel,Alex Straumann,Barry K. Wershil,Marc E. Rothenberg,Seema S. Aceves +32 more
TL;DR: A new conceptual definition is proposed highlighting that EoE represents a chronic, immune/antigen-mediated disease characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation.
Journal ArticleDOI
Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment.
Glenn T. Furuta,Chris A. Liacouras,Margaret H. Collins,Sandeep K. Gupta,Chris Justinich,Phil E. Putnam,Peter A Bonis,Eric Hassall,Alex Straumann,Marc E. Rothenberg +9 more
TL;DR: A multidisciplinary task force of 31 physicians assembled with the goal of determining diagnostic criteria and making recommendations for evaluation and treatment of children and adults with suspected eosinophilic esophagitis (EE) provided current recommendations for care of affected patients.
Journal ArticleDOI
Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years
Alex Straumann,Hans-Peter Spichtin,Leticia Grize,Kathleen A. Bucher,Christoph Beglinger,Hans-Uwe Simon +5 more
TL;DR: Eosinophilic esophagitis, a primary and chronic disease restricted to the esophagus, leads to persistent dysphagia and structural esophageal alterations but does not impact the nutritional state.
Journal ArticleDOI
Endoscopic assessment of the oesophageal features of eosinophilic oesophagitis: validation of a novel classification and grading system
TL;DR: The proposed system for endoscopically-identified oesophageal features of EoE defines common nomenclature and severity scores for the assessment of EiE disease activity and has good interobserver agreement among practising and academic gastroenterologists.
Journal ArticleDOI
Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis.
TL;DR: Significant histologic variability exists among biopsy specimens from individual patients with EE and necessitates multiple biopsies to improve diagnostic sensitivity, and marked variability within and between biopsy specimen of individual patients is revealed.
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