Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults
Elena Volpi,Hisamine Kobayashi,Melinda Sheffield-Moore,Bettina Mittendorfer,Bettina Mittendorfer,Robert R. Wolfe,Robert R. Wolfe +6 more
TLDR
Essential amino acids are primarily responsible for the amino acid-induced stimulation of muscle protein anabolism in the elderly.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2003-08-01 and is currently open access. It has received 778 citations till now. The article focuses on the topics: Hyperaminoacidemia & Anabolism.read more
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Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN Expert Group
Nicolaas E. P. Deutz,Jürgen M. Bauer,Rocco Barazzoni,Gianni Biolo,Yves Boirie,Anja Bosy-Westphal,Tommy Cederholm,Tommy Cederholm,Alfonso J. Cruz-Jentoft,Zeljko Krznaric,K. Sreekumaran Nair,Pierre Singer,Daniel Teta,Kevin D. Tipton,Philip C. Calder,Philip C. Calder +15 more
TL;DR: Recommendations are made that daily physical activity or exercise (resistance training, aerobic exercise) should be undertaken by all older people, for as long as possible to help older adults sustain muscle strength and function into older age.
Journal ArticleDOI
Sarcopenia: Its assessment, etiology, pathogenesis, consequences and future perspectives
Yves Rolland,Stefan A. Czerwinski,G. Abellan Van Kan,John E. Morley,Matteo Cesari,Graziano Onder,Jean Woo,Richard N. Baumgartner,Fabien Pillard,Yves Boirie,Wm. Cameron Chumlea,Bruno Vellas +11 more
TL;DR: On-going and future clinical trials on sarcopenia may radically change the authors' preventive and therapeutic approaches of mobility disability in older people.
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A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
Christos S. Katsanos,Christos S. Katsanos,Hisamine Kobayashi,Melinda Sheffield-Moore,Asle Aarsland,Robert R. Wolfe +5 more
TL;DR: It is concluded that increasing the proportion of leucine in a mixture of EAA can reverse an attenuated response of muscleprotein synthesis in elderly but does not result in further stimulation of muscle protein synthesis in young subjects.
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Dietary protein recommendations and the prevention of sarcopenia.
TL;DR: Clinicians should stress the importance of ingesting a sufficient amount of protein with each meal to preserve skeletal muscle mass in ageing and propose a novel and specific dietary approach to prevent or slow down muscle loss with ageing.
References
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Exercise training and nutritional supplementation for physical frailty in very elderly people
Maria A. Fiatarone,Evelyn F. O'Neill,Nancy D. Ryan,Karen M. Clements,Guido R. Solares,Miriam E. Nelson,Susan B. Roberts,Joseph J. Kehayias,Lewis A. Lipsitz,William J. Evans +9 more
TL;DR: High-intensity resistance exercise training is a feasible and effective means of counteracting muscle weakness and physical frailty in very elderly people, in contrast to multi-nutrient supplementation without concomitant exercise, which does not reduce muscle weakness orPhysical frailty.
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Falls, Injuries Due to Falls, and the Risk of Admission to a Nursing Home
TL;DR: Among older people living in the community falls are a strong predictor of placement in a skilled-nursing facility; interventions that prevent falls and their sequelae may therefore delay or reduce the frequency of nursing home admissions.
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An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein
TL;DR: It is concluded that the stimulatory effect of exogenous amino acids on muscle protein synthesis is enhanced by prior exercise, perhaps in part because of enhanced blood flow, implying that protein intake immediately after exercise may be more anabolic than when ingested at some later time.
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Leucine Stimulates Translation Initiation in Skeletal Muscle of Postabsorptive Rats via a Rapamycin-Sensitive Pathway
Joshua C. Anthony,Fumiaki Yoshizawa,Tracy G. Anthony,Thomas C. Vary,Leonard S. Jefferson,Scot R. Kimball +5 more
TL;DR: It is demonstrated for the first time that leucine-dependent stimulation of translation initiation in vivo occurs via a rapamycin-sensitive pathway and is unique among the branched-chain amino acids in its ability to stimulate protein synthesis in skeletal muscle of food-deprived rats.