Journal ArticleDOI
Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis
Dorothy A Machalek,Mary Poynten,Fengyi Jin,Christopher K Fairley,Annabelle Farnsworth,Suzanne M. Garland,Suzanne M. Garland,Suzanne M. Garland,Richard J. Hillman,Richard J. Hillman,Kathy Petoumenos,Jennifer M. Roberts,Sepehr N. Tabrizi,Sepehr N. Tabrizi,Sepehr N. Tabrizi,David J Templeton,David J Templeton,Andrew E. Grulich +17 more
TLDR
In this paper, the authors search PubMed, OVID Medline, and Embase for all studies published before Nov 1, 2011, that reported prevalence and incidence of anal HPV detection, intraepithelial neoplasia (AIN), and anal cancer in MSM.Abstract:
Summary Background Men who have sex with men (MSM) are at greatly increased risk of human papillomavirus (HPV)-associated anal cancer. Screening for the presumed cancer precursor, high-grade anal intraepithelial neoplasia (AIN), followed by treatment in a manner analogous to cervical screening, has been proposed. We aimed to assess available data for anal HPV disease that can inform pre-cancer screening programmes. Methods We searched PubMed, OVID Medline, and Embase for all studies published before Nov 1, 2011, that reported prevalence and incidence of anal HPV detection, AIN, and anal cancer in MSM. We calculated summary estimates using random-effects meta-analysis. Findings 53 studies met the inclusion criteria, including 31 estimates of HPV prevalence, 19 estimates of cytological abnormalities, eight estimates of histological abnormalities, and nine estimates of anal cancer incidence. Data for incident HPV and high-grade AIN were scarce. In HIV-positive men, the pooled prevalence of anal HPV-16 was 35·4% (95% CI 32·9–37·9). In the only published estimate, incidence of anal HPV-16 was 13·0% (9·6–17·6), and clearance occurred in 14·6% (10·2–21·2) of men per year. The pooled prevalence of histological high-grade AIN was 29·1% (22·8–35·4) with incidences of 8·5% (6·9–10·4) and 15·4% (11·8–19·8) per year in two estimates. The pooled anal cancer incidence was 45·9 per 100 000 men (31·2–60·3). In HIV-negative men, the pooled prevalence of anal HPV-16 was 12·5% (9·8–15·4). Incidence of HPV-16 was 11·8% (9·2–14·9) and 5·8% (1·9–13·5) of men per year in two estimates. The pooled prevalence of histological high-grade AIN was 21·5% (13·7–29·3), with incidence of 3·3% (2·2–4·7) and 6·0% (4·2–8·1) per year in two estimates. Anal cancer incidence was 5·1 per 100 000 men (0–11·5; based on two estimates). There were no published estimates of high-grade AIN regression. Interpretation Anal HPV and anal cancer precursors were very common in MSM. However, on the basis of restricted data, rates of progression to cancer seem to be substantially lower than they are for cervical pre-cancerous lesions. Large, good-quality prospective studies are needed to inform the development of anal cancer screening guidelines for MSM. Funding Australian Government Department of Health and Ageing.read more
Citations
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Journal ArticleDOI
Sexually transmitted diseases treatment guidelines, 2015.
Kimberly A. Workowski,Gail Bolan +1 more
TL;DR: These guidelines for the treatment of persons who have or are at risk for sexually transmitted diseases (STDs) were updated by CDC after consultation with a group of professionals knowledgeable in the field of STDs who met in Atlanta on April 30-May 2, 2013.
Journal ArticleDOI
Global burden of human papillomavirus and related diseases.
David Forman,Catherine de Martel,Charles J.N. Lacey,Isabelle Soerjomataram,Joannie Lortet-Tieulent,Laia Bruni,Jérôme Vignat,Jacques Ferlay,Freddie Bray,Martyn Plummer,Silvia Franceschi +10 more
TL;DR: Cervical cancer is the third most common female malignancy and shows a strong association with level of development, rates being at least four-fold higher in countries defined within the low ranking of the Human Development Index (HDI) compared with those in the very high category.
Human papillomavirus vaccination: recommendations of the Advisory Committee on Immunization Practices (ACIP).
Lauri E. Markowitz,Eileen F. Dunne,Mona Saraiya,Harrell W. Chesson,Curtis Cr,Julianne Gee,Joseph A. Bocchini,Elizabeth R. Unger +7 more
TL;DR: This report summarizes the epidemiology of human papillomavirus (HPV) and associated diseases, describes the licensed HPV vaccines, provides updated data from clinical trials and postlicensure safety studies, and compiles recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) for use of HPV vaccines.
Journal ArticleDOI
The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology
Teresa M. Darragh,Terence J. Colgan,J. Thomas Cox,Debra S. Heller,Michael R. Henry,Ronald D. Luff,Ronald D. Luff,Timothy H. McCalmont,Ritu Nayar,Joel M. Palefsky,Mark H. Stoler,Edward J. Wilkinson,Richard J. Zaino,David C. Wilbur +13 more
TL;DR: The Lower Anogenital Squamous Terminology (LAST) Project as mentioned in this paper was created to create a histopathologic nomenclature system that reflects current knowledge of human papillomavirus (HPV)-associated squamous lesions of the lower anogenital tract.
Journal ArticleDOI
Human papillomavirus and cervical cancer.
TL;DR: More sensitive than cytology, primary screening by human papillomavirus testing could enable screening intervals to be extended and if these prevention strategies can be implemented in developing countries, many thousands of lives could be saved.
References
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Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
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Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases.
Suzanne M. Garland,Suzanne M. Garland,Mauricio Hernández-Ávila,Cosette M. Wheeler,Gonzalo Perez,Diane M. Harper,Sepp Leodolter,Grace W.K. Tang,Daron G. Ferris,Marc Steben,Janine T. Bryan,Frank J. Taddeo,Radha Railkar,Mark T. Esser,Heather L. Sings,Micki Nelson,John W. Boslego,Carlos Sattler,Eliav Barr,Laura A. Koutsky +19 more
TL;DR: The quadrivalent vaccine significantly reduced the incidence of HPV-associated anogenital diseases in young women in this randomized, placebo-controlled, doubleblind trial.
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