Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: Updated criteria and genotype assignment web resource
D B Smith,Jens Bukh,Carla Kuiken,A. Scott Muerhoff,Charles M. Rice,Jack T. Stapleton,Peter Simmonds +6 more
TLDR
This study represents a major update to the previous consensus HCV classification, incorporating additional sequence information derived from over 1,300 (near‐)complete genome sequences of HCV available on public databases in May 2013.About:
This article is published in Hepatology.The article was published on 2014-01-01 and is currently open access. It has received 1219 citations till now. The article focuses on the topics: Voxilaprevir.read more
Citations
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A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology.
Andrew Rambaut,Edward C. Holmes,Áine O'Toole,Verity Hill,John T. McCrone,Christopher Ruis,Louis du Plessis,Oliver G. Pybus +7 more
TL;DR: A rational and dynamic virus nomenclature that uses a phylogenetic framework to identify those lineages that contribute most to active spread and is designed to provide a real-time bird’s-eye view of the diversity of the hundreds of thousands of genome sequences collected worldwide.
EASL Clinical Practice Guidelines: Management of hepatitis C virus infection European Association for the Study of the Liver ⇑
TL;DR: The EASL CPGs on the management of HCV infection will be updated on a regular basis upon approval of additional novel therapies, and will apply to therapies that are approved at the time of their publication.
Journal ArticleDOI
Global Distribution and Prevalence of Hepatitis C Virus Genotypes
Jane P. Messina,Isla Humphreys,Abraham D. Flaxman,Anthony Brown,Graham S Cooke,Oliver G. Pybus,Eleanor Barnes +6 more
TL;DR: It is calculated that HCV genotype 1 is the most prevalent worldwide, comprising 83.4 million cases (46.2% of all HCV cases), approximately one‐third of which are in East Asia.
Journal ArticleDOI
Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes.
Arnolfo Petruzziello,Samantha Marigliano,Giovanna Loquercio,Anna Cozzolino,Carmela Cacciapuoti +4 more
TL;DR: Although HCV genotypes 1 and 3 infections are the most prevalent globally (67.0% if considered together), other genotypes are found more commonly in lower-income countries where still account for a significant proportion of HCV cases.
Journal ArticleDOI
Consensus proposals for classification of the family Hepeviridae
D B Smith,Peter Simmonds,Shahid Jameel,Suzanne U. Emerson,Tim J. Harrison,Xiang-Jin Meng,Hiroaki Okamoto,Wim H.M. van der Poel,Michael A. Purdy +8 more
TL;DR: This work proposes a taxonomic scheme in which the family Hepeviridae is divided into the genera Orthohepevirus (all mammalian and avian hepatitis E virus (HEV) isolates) and PiscihepeVirus (cutthroat trout virus), and proposals are made for the designation of genotypes within the human and rat HEVs.
References
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Journal ArticleDOI
MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods
Koichiro Tamura,Daniel S. Peterson,Nicholas Peterson,Glen Stecher,Masatoshi Nei,Sudhir Kumar +5 more
TL;DR: The newest addition in MEGA5 is a collection of maximum likelihood (ML) analyses for inferring evolutionary trees, selecting best-fit substitution models, inferring ancestral states and sequences, and estimating evolutionary rates site-by-site.
Journal ArticleDOI
MUSCLE: multiple sequence alignment with high accuracy and high throughput
TL;DR: MUSCLE is a new computer program for creating multiple alignments of protein sequences that includes fast distance estimation using kmer counting, progressive alignment using a new profile function the authors call the log-expectation score, and refinement using tree-dependent restricted partitioning.
Journal ArticleDOI
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
TL;DR: A random-primed complementary DNA library was constructed from plasma containing the uncharacterized non-A, non-B hepatitis agent and screened with serum from a patient diagnosed with NANBH, showing consistent with the agent being similar to the togaviridae or flaviviridae.
Journal ArticleDOI
Genetic organization and diversity of the hepatitis C virus.
Q L Choo,K H Richman,Jang Han,Kim Berger,C Lee,Christine Dong,C Gallegos,D Coit,R Medina-Selby,P J Barr +9 more
TL;DR: The nucleotide sequence of the RNA genome of the human hepatitis C virus has been determined and significant genome diversity is apparent within the putative 5' structural gene region of different HCV isolates, suggesting the presence of closely related but distinct viral genotypes.
Journal ArticleDOI
Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes.
Peter Simmonds,Jens Bukh,Christophe Combet,Gilbert Deléage,Nobuyuki Enomoto,Stephen M. Feinstone,Phillippe Halfon,Geneviève Inchauspé,Carla Kuiken,Geert Maertens,Masashi Mizokami,Donald G. Murphy,Hiroaki Okamoto,Jean-Michel Pawlotsky,François Penin,Erwin Sablon,Tadasu Shin-I,Lieven Stuyver,Heinz-Jürgen Thiel,Sergei Viazov,Amy J. Weiner,Anders Widell +21 more
TL;DR: These proposals provide the framework by which the HCV databases store and provide access to data on HCV, which will internationally coordinate the assignment of new genotypes and subtypes in the future.
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Sofosbuvir for previously untreated chronic hepatitis C infection
Eric Lawitz,Alessandra Mangia,David L. Wyles,Maribel Rodriguez-Torres,Tarek Hassanein,Stuart C. Gordon,Michael Schultz,M. Davis,Zeid Kayali,K. Rajender Reddy,Ira M. Jacobson,Kris V. Kowdley,L. Nyberg,G. Mani Subramanian,Robert H. Hyland,Sarah Arterburn,Deyuan Jiang,John McNally,Diana M. Brainard,William T. Symonds,John G. McHutchison,Aasim Sheikh,Zobair M. Younossi,Edward Gane +23 more