Journal ArticleDOI
Experimental studies of protein folding and unfolding
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This article is published in Progress in Biophysics & Molecular Biology.The article was published on 1979-01-01. It has received 501 citations till now. The article focuses on the topics: Phi value analysis & Protein folding.read more
Citations
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From Levinthal to pathways to funnels
Ken A. Dill,Hue Sun Chan +1 more
TL;DR: The general energy landscape picture provides a conceptual framework for understanding both two-state and multi-state folding kinetics and hopes to learn much more about the real shapes of protein folding landscapes.
Book ChapterDOI
Determination and analysis of urea and guanidine hydrochloride denaturation curves.
Journal ArticleDOI
Hydrogen exchange and structural dynamics of proteins and nucleic acids
TL;DR: Though the structures presented in crystallographic models of macromolecules appear to possess rock-like solidity, real proteins and nucleic acids are not particularly rigid.
Journal ArticleDOI
Stability of Protein Pharmaceuticals
TL;DR: Current methodology to stabilize proteins is presented, including additives, excipients, chemical modification, and the use of site-directed mutagenesis to produce a more stable protein species.
Patent
Method for reducing the immunogenicity of antibody variable domains
TL;DR: In this paper, a unique method was disclosed for identifying and replacing immunoglobulin surface amino acid residues which converted the antigenicity of a first mammalian species to that of a second mammalian species.
References
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Journal ArticleDOI
Electrochemical Photolysis of Water at a Semiconductor Electrode
Akira Fujishima,Kenichi Honda +1 more
TL;DR: Water photolysis is investigated by exploiting the fact that water is transparent to visible light and cannot be decomposed directly, but only by radiation with wavelengths shorter than 190 nm.
Journal ArticleDOI
On the Nature of Allosteric Transitions: A Plausible Model
TL;DR: "It is certain that all bodies whatsoever, though they have no sense, yet they have perception, and whether the body be alterant or alterec, evermore a perception precedeth operation; for else all bodies would be like one to another."
Journal ArticleDOI
Principles that Govern the Folding of Protein Chains
TL;DR: Anfinsen as discussed by the authors provided a sketch of the rich history of research that provided the foundation for his work on protein folding and the Thermodynamic Hypothesis, and outlined potential avenues of current and future scientific exploration.
Journal ArticleDOI
Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
TL;DR: The use of the foregoing analytical method in the determination of total and oxidized glutathione contents of rat blood, kidney, and liver gave values in good agreement with those obtained by previous investigators.
Related Papers (5)
Specific intermediates in the folding reactions of small proteins and the mechanism of protein folding.
Peter S. Kim,Robert L. Baldwin +1 more