Journal ArticleDOI
Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey
Josef Riedler,Charlotte Braun-Fahrländer,Waltraud Eder,Mynda Schreuer,Marco Waser,Soyoun Maisch,David Carr,Rudi Schierl,Dennis Nowak,Erika von Mutius +9 more
TLDR
Long-term and early-life exposure to stables and farm milk induces a strong protective effect against development of asthma, hay fever, and atopic sensitisation in children.About:
This article is published in The Lancet.The article was published on 2001-10-06. It has received 1452 citations till now. The article focuses on the topics: Hay fever & Environmental exposure.read more
Citations
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Journal ArticleDOI
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.
E. Joanna Baxter,Linda M. Scott,Peter J. Campbell,Clare L. East,Nasios Fourouclas,Soheila Swanton,George S. Vassiliou,Anthony J. Bench,Elaine M. Boyd,Natasha Curtin,Michael A. Scott,Wendy N. Erber,Anthony R. Green,Anthony R. Green +13 more
TL;DR: A single acquired mutation of JAK2 was noted in more than half of patients with a myeloproliferative disorder and its presence in all erythropoietin-independent erythroid colonies demonstrates a link with growth factor hypersensitivity, a key biological feature of these disorders.
Journal ArticleDOI
The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
TL;DR: This review examines the evidence in support of the hygiene hypothesis and offers a number of mechanisms that could explain the relation between sanitary conditions and susceptibility to allergic and autoimmune diseases.
Journal ArticleDOI
Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
TL;DR: Gut microflora might be a hitherto unexplored source of natural immunomodulators and probiotics, for prevention of atopic disease in children at high risk.
Journal ArticleDOI
Environmental exposure to endotoxin and its relation to asthma in school-age children.
Charlotte Braun-Fahrländer,Josef Riedler,Udo Herz,Waltraud Eder,Marco Waser,Leticia Grize,Soyoun Maisch,David Carr,Florian Gerlach,Albrecht Bufe,Roger Lauener,Rudolf Schierl,Harald Renz,Dennis Nowak,Erika von Mutius +14 more
TL;DR: A subject's environmental exposure to endotoxin may have a crucial role in the development of tolerance to ubiquitous allergens found in natural environments.
Journal ArticleDOI
Allergy, Parasites, and the Hygiene Hypothesis
TL;DR: The induction of a robust anti-inflammatory regulatory network by persistent immune challenge offers a unifying explanation for the observed inverse association of many infections with allergic disorders.
References
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Journal Article
Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee.
TL;DR: The variation in the prevalences of asthma, allergic rhinoconjunctivitis, and atopic-eczema symptoms is striking between different centres throughout the world and will form the basis of further studies to investigate factors that potentially lead to these international patterns.
Journal ArticleDOI
Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC
TL;DR: In this article, the authors investigated worldwide prevalence of asthma, allergic rhinoconjunctivitis, and atopic disorders in children, and found differences of between 20-fold and 60-fold between centres in the prevalence of symptoms of asthma.
Journal Article
Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.
Steven E. Macatonia,Nancy Ann Hosken,Mark J. Litton,Pedro L. Vieira,Chyi-Song Hsieh,J. A. Culpepper,Maria Wysocka,Giorgio Trinchieri,Kenneth M. Murphy,Anne O'Garra +9 more
TL;DR: In addition to inducing proliferation and clonal expansion of naive T cells, dendritic cells, by their production of IL-12, play a direct role in the development of IFN-gamma-producing cells that are important for cell-mediated immune responses.
Journal ArticleDOI
Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin
TL;DR: How LBP enables LPS binding to CD14 and how complexes of LPS and soluble or GPI-anchored CD14 participate in cell activation are discussed, and the evidence supporting a model for a functional LPS receptor of myeloid cells, which is multimeric, is reviewed.
Journal Article
The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction.
TL;DR: It is suggested that intestinal bacterial flora play a crucial role in generating a Th2 cell population whose size and response are adequately regulated and, consequently, fully susceptible to oral tolerance induction, probably by affecting the development of gut-associated lymphoid tissue at the neonatal stage.