Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity
TLDR
The data suggest that the 17 beta-HSD type 2 cDNA encodes the microsomal 17 beta -HSD of human placenta, described by several laboratories.About:
This article is published in Journal of Biological Chemistry.The article was published on 1993-06-15 and is currently open access. It has received 427 citations till now. The article focuses on the topics: 17beta-hydroxysteroid dehydrogenase & Endoplasmic reticulum.read more
Citations
More filters
Journal ArticleDOI
The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.
TL;DR: Understanding steroidogenesis is of fundamental importance to understanding disorders of sexual differentiation, reproduction, fertility, hypertension, obesity, and physiological homeostasis.
Journal ArticleDOI
Short-chain dehydrogenases/reductases (SDR).
Hans Jörnvall,Bengt Persson,Maria Krook,Sílvia Atrian,Roser Gonzàlez-Duarte,Jonathan Jeffery,Debashis Ghosh +6 more
TL;DR: In the combined SDR superfamily, only one residue is strictly conserved and ascribed a crucial enzymatic function (Tyr 151 in the numbering system of human NAD(+)-linked prostaglandin dehydrogenase), and such a function is supported by chemical modifications, site-directed mutagenesis, and an active site position in those tertiary structures that have been characterized.
Journal ArticleDOI
Functional role of estrogen metabolism in target cells: review and perspectives.
Bao Ting Zhu,Allan H. Conney +1 more
TL;DR: Some of the many actions of estradiol may not be caused by est radiol per se, but may result from the formation of active estrogen metabolite(s) which function as local mediators or may activate their own unique receptors or effectors.
Journal ArticleDOI
Sex steroids and bone.
TL;DR: Loss of nongenotropic anti-apoptotic effects on mature osteoblasts and osteocytes, in combination with an opposite effect on the lifespan of mature osteoclasts, may be responsible for the imbalance between formation and resorption and the progressive loss of bone mass and strength.
Journal ArticleDOI
Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme
TL;DR: The 11β-hydroxysteroid dehydrogenase (11βHSD) as mentioned in this paper was found to protect the nonselective mineralocorticoid receptor from occupation by glucocorticity, and to modulate access of glucoc Corticoid to glucoc corticoid receptors resulting in protection of the fetus and gonads.
References
More filters
Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.