Expression profile of tuberin and some potential tumorigenic factors in 60 patients with uterine leiomyomata.
TLDR
There are two broad groups of uterine leiomyomata associated with an alteration of tuberin and glucocorticoid receptor, and one group is associated with upregulation of human mobility group gene A2 and steroid receptor cofactors.About:
This article is published in Modern Pathology.The article was published on 2005-02-01 and is currently open access. It has received 43 citations till now. The article focuses on the topics: Myometrium & Steroid biosynthesis.read more
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Uterine Fibroids: The Elephant in the Room
TL;DR: Uterine fibroids (leiomyomas) have historically been viewed as important chiefly as the major indication for hysterectomy but an awareness of the role of genetics, the extracellular matrix, and hormones in tumor etiology is key to understanding this disease.
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PEComas: the past, the present and the future.
TL;DR: An innovative therapeutic trial using rapamycin is under way for tumors occurring in TSC such as renal angiomyolipoma and lymphangioleiomyomatosis, which could provide the rationale for the use of the same drug in other lesions composed of PECs, especially in the malignant ones.
Management of uterine fibroids: an update of the evidence.
Meera Viswanathan,Katherine E Hartmann,N McKoy,Gretchen Stuart,Nicole Rankins,Patricia Thieda,Linda J Lux,Kathleen N. Lohr +7 more
TL;DR: The dearth of high-quality evidence supporting the effectiveness of most interventions for uterine fibroids is remarkable, given how common this problem is and the current state of the literature does not permit definitive conclusions about benefit, harm, or relative costs to help guide women's choices.
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Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma.
TL;DR: The findings suggest that the Let-7–mediated repression of HMGA2 mechanism can be an important molecular event in leiomyoma growth.
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Constitutive Activation of Beta-Catenin in Uterine Stroma and Smooth Muscle Leads to the Development of Mesenchymal Tumors in Mice
Pradeep S. Tanwar,Ho-Joon Lee,Li Hua Zhang,Lawrence R. Zukerberg,Makoto Mark Taketo,Bo R. Rueda,José A. Teixeira +6 more
TL;DR: Evidence is shown suggesting that dysregulated, stromal, and myometrial WNT/beta-catenin signaling has pleiotropic effects on uterine function and tumorigenesis.
References
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Cluster analysis and display of genome-wide expression patterns
TL;DR: A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity in pattern of gene expression, finding in the budding yeast Saccharomyces cerevisiae that clustering gene expression data groups together efficiently genes of known similar function.
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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
TL;DR: It is shown that TSC1–TSC2 inhibits the p70 ribosomal protein S6 kinase 1 and activates the eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translational initiation) and these functions are mediated by inhibition of the mammalian target of rapamycin (mTOR).
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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.
Ian Tomlinson,Alam Na,Andrew Rowan,Ella Barclay,Emma Jaeger,David P. Kelsell,Irene M. Leigh,Gorman P,H. Lamlum,Shamima Rahman,Roylance Rr,Simon E. Olpin,Steve Bevan,Karen Barker,N Hearle,Richard S. Houlston,Maija Ht Kiuru,Rainer Lehtonen,Auli Karhu,Susa Vilkki,Päivi Laiho,Eklund C,Outi Vierimaa,Kristiina Aittomäki,Marja Hietala,Pertti Sistonen,Anders Paetau,Reijo Salovaara,Riitta Herva,Launonen,Lauri A. Aaltonen +30 more
TL;DR: It is shown that a gene that predisposes to multiple fibroids, cutaneous leiomyomata and renal cell carcinoma is mapped to chromosome 1q42, and that this gene encodes fumarate hydratase, an enzyme of the tricarboxylic acid cycle.
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Akt regulates growth by directly phosphorylating Tsc2.
TL;DR: Drosophila melanogaster Tsc2 seems to be the critical target of Akt in mediating growth signals for the insulin signalling pathway, and Stimulating Akt/PKB signalling in vivo markedly increases cell growth/size, disrupts the Tsc1–Tsc2 complex and disturbs the distinct subcellular localization of T Sc2.
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Etiology and pathogenesis of uterine leiomyomas: a review.
TL;DR: Growth factors with mitogenic activity, such as transforming growth factor- (subscript)3(/subscript), basic fibroblast growth factor, epidermal growth factors, and insulin-like growth factors-I, are elevated in fibroids and may be the effectors of estrogen and progesterone promotion.