Journal ArticleDOI
Extent of resection and survival in glioblastoma multiforme: identification of and adjustment for bias.
Walter Stummer,Hanns-Jürgen Reulen,Thomas Meinel,Uwe Pichlmeier,Wiebke Schumacher,Jörg-Christian Tonn,Veit Rohde,Falk Oppel,Bernd Turowski,Christian Woiciechowsky,Kea Franz,Torsten Pietsch +11 more
TLDR
The present data provide Level 2b evidence (Oxford Centre for Evidence-based Medicine) that survival depends on complete resection of enhancing tumor in glioblastoma multiforme and treatment bias was demonstrated regarding resection and second-line therapies.Abstract:
Treatment bias was demonstrated regarding resection and second-line therapies. However, bias and imbalances were controllable in the cohorts available from the 5-aminolevulinic acid study so that the present data now provide Level 2b evidence (Oxford Centre for Evidence-based Medicine) that survival depends on complete resection of enhancing tumor in glioblastoma multiforme.read more
Citations
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Journal ArticleDOI
Malignant Gliomas in Adults
Patrick Y. Wen,Santosh Kesari +1 more
TL;DR: The authors found that approximately 5% of patients with malignant gliomas have a family history of glioma and most of these familial cases are associated with rare genetic syndromes, such as neurofibromatosis types 1 and 2, the Li−Fraumeni syndrome (germ-line p53 mutations associated with an increased risk of several cancers), and Turcot's syndrome (intestinal polyposis and brain tumors).
Journal ArticleDOI
An extent of resection threshold for newly diagnosed glioblastomas.
TL;DR: For patients with newly diagnosed GBMs, aggressive EOR equates to improvement in overall survival, even at the highest levels of resection, and stepwise improvement in survival was evident even in the 95%-100% EOR range.
Journal ArticleDOI
Epidemiologic and Molecular Prognostic Review of Glioblastoma
Jigisha P. Thakkar,Therese A. Dolecek,Craig Horbinski,Quinn T. Ostrom,Donita Lightner,Jill S. Barnholtz-Sloan,John L. Villano +6 more
TL;DR: The current epidemiology of GBM is reported with new data from the Central Brain Tumor Registry of the United States 2006 to 2010 as well as demonstrate and discuss trends in incidence and survival.
Journal ArticleDOI
Impact of Intraoperative Stimulation Brain Mapping on Glioma Surgery Outcome: A Meta-Analysis
Philip C. De Witt Hamer,Santiago Gil Robles,Aeilko H. Zwinderman,Hugues Duffau,Mitchel S. Berger +4 more
TL;DR: Glioma resections using ISM are associated with fewer late severe neurologic deficits and more extensive resection, and they involve eloquent locations more frequently, indicating that ISM should be universally implemented as standard of care for glioma surgery.
Journal ArticleDOI
Intraoperative MRI guidance and extent of resection in glioma surgery: a randomised, controlled trial
TL;DR: This study provides evidence for the use of intraoperative MRI guidance in glioma surgery: such imaging helps surgeons provide the optimum extent of resection.
References
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Journal ArticleDOI
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Roger Stupp,Warren P. Mason,Martin J. van den Bent,Michael Weller,Barbara Fisher,Martin J.B. Taphoorn,Karl Belanger,Alba A. Brandes,Christine Marosi,Ulrich Bogdahn,Jürgen Curschmann,Robert C. Janzer,Samuel K. Ludwin,Thierry Gorlia,Anouk Allgeier,Denis Lacombe,J. Gregory Cairncross,Elizabeth Eisenhauer,René O. Mirimanoff +18 more
TL;DR: The addition of temozolomide to radiotherapy for newly diagnosed glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity.
Journal ArticleDOI
Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Walter Stummer,Uwe Pichlmeier,Thomas Meinel,Otmar D. Wiestler,Friedhelm E. Zanella,Hans-Jürgen Reulen +5 more
TL;DR: Tumour fluorescence derived from 5-aminolevulinic acid enables more complete resections of contrast-enhancing tumour, leading to improved progression-free survival in patients with malignant glioma.
Journal ArticleDOI
A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival
Michel Lacroix,Dima Abi-Said,Daryl R. Fourney,Ziya L. Gokaslan,Weiming Shi,Franco DeMonte,Frederick F. Lang,Ian E. McCutcheon,Samuel J. Hassenbusch,Eric C. Holland,Kenneth R. Hess,Christopher Michael,Daniel J. Miller,Raymond Sawaya +13 more
TL;DR: Gross-total tumor resection is associated with longer survival in patients with GBM, especially when other predictive variables are favorable.
Journal ArticleDOI
Interrater Reliability of the NIH Stroke Scale
TL;DR: The interobserver reliability of a rating scale employed in several multicenter stroke trials was investigated and compares favorably with other scales for which such comparisons can be made.
Journal ArticleDOI
Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients.
TL;DR: The usefulness of 5-ALA-induced tumor fluorescence for guiding tumor resection on postoperative magnetic resonance (MR) imaging and survival in patients who underwent surgery in the authors' department is indicated.
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