Journal ArticleDOI
Fate of septohippocampal neurons following fimbria-fornix transection: a time course analysis.
TLDR
The size (area and diameter) of FG-labeled somata decreased in both the MS and vDB within three weeks following fimbria-fornix transection and remained relatively constant at the six- and ten-week time points.About:
This article is published in Brain Research Bulletin.The article was published on 1990-07-01. It has received 60 citations till now. The article focuses on the topics: Axotomy & Nissl body.read more
Citations
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Journal ArticleDOI
Physiology of the neurotrophins
Gary R. Lewin,Yves-Alain Barde +1 more
TL;DR: Rapid actions of neurotrophin-3 on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system.
Journal ArticleDOI
Expression, control, and probable functional significance of the neuronal theta-rhythm
TL;DR: Analysis of extracellularly recorded neuronal activity in alert rabbits, intact and after various brain lesions, in slices and transplants of the hippocampus and septum allow one to make the following conclusions.
Journal ArticleDOI
Effects of estrogen and fimbria/fornix transection on p75NGFR and ChAT expression in the medial septum and diagonal band of Broca.
Robert B. Gibbs,Donald W. Pfaff +1 more
TL;DR: The data suggest that p75NGFR expression may play a role in regulating the functioning of specific basal forebrain cholinergic neurons and are consistent with the possibility that continuous, long-term exposure to gonadal steroids may contribute to a loss of p75 NGFR-expressing neurons with age.
Journal ArticleDOI
Specificity of 192 IgG-saporin for NGF receptor-positive cholinergic basal forebrain neurons in the rat
TL;DR: ChAT immunohistochemistry was confirmative of major cell loss in the CBF, while other cholinergic nuclei appeared unremarkable, providing further evidence of the selectivity of 192 IgG-saporin in abolishing cholinerential, NGF receptor-positive CNS neurons.
Journal ArticleDOI
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.
Karim Belarbi,Sylvie Burnouf,Francisco-Jose Fernandez-Gomez,Cyril Laurent,Sophie Lestavel,Martin Figeac,Audrey Sultan,Laetitia Troquier,Antoine Leboucher,Raphaëlle Caillierez,Marie-Eve Grosjean,Dominique Demeyer,Hélène Obriot,I. Brion,B. Barbot,Marie-Christine Galas,Bart Staels,Sandrine Humez,Nicolas Sergeant,Susanna Schraen-Maschke,Anne Muhr-Tailleux,Malika Hamdane,Luc Buée,David Blum +23 more
TL;DR: The data support the view that long-term voluntary physical exercise is an effective strategy capable of mitigating Tau pathology and its pathophysiological consequences, and prevent memory alterations in THY-Tau22 mice.
References
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Journal ArticleDOI
Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.
TL;DR: The use of avidin-biotin interaction in immunoenzymatic techniques provides a simple and sensitive method to localize antigens in formalin-fixed tissues.
Journal ArticleDOI
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
TL;DR: It is suggested that fimbrial transections resulted in retrograde degeneration of cholinergic septo-hippocampal neurons and that NGF treatment strongly attenuated this lesion-induced degeneration.
Journal ArticleDOI
Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection
Lawrence R. Williams,Silvio Varon,Gary M. Peterson,Klas Wictorin,Walter Fischer,Anders Björklund,Fred H. Gage +6 more
TL;DR: It is reported here that NGF treatment significantly reduces both the total neuronal and cholinergic neuronal death found 2 weeks after fimbria fornix transection; there was a sparing of 50% of the neurons in the MS and essentially 100% of those in the VDB that otherwise would have died.
Book ChapterDOI
The Axon Reaction: A Review of the Principal Features of Perikaryal Responses to Axon Injury
TL;DR: This chapter provides an overview of the principal features of perikaryal responses to axon injury and changes in axotomized neurons are generally assessed by comparison with the corresponding contralateral neurons of the experimental animal.
Journal ArticleDOI
Nerve growth factor treatment after brain injury prevents neuronal death
TL;DR: Cholinergic neuronal degeneration after axotomy has been proposed to be due to the loss of a retrogradely transported neurotrophic factor, possibly nerve growth factor (NGF), and NGF was continuously infused into the lateral ventricles of adult rats that had received bilateral lesions of all cholinergic axons projecting from the medial septum to the dorsal hippocampus.