Journal ArticleDOI
First and repeat liver resection for primary and recurrent intrahepatic cholangiocarcinoma.
Regis Souche,Pietro Addeo,Elie Oussoultzoglou,Astrid Herrero,Edoardo Rosso,Francis Navarro,Jean Michel Fabre,Philippe Bachellier +7 more
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TLDR
Tumor size more than 5 cm represents an independent risk factor for recurrence after resection of ICC and in case of recurrent ICC, when feasible, is associated with longer overall survival.Abstract:
Background Recurrence after resection of intrahepatic cholangiocarcinoma (ICC) remains common. The present study sought to evaluate risk factors for recurrence and the results of repeat liver resection (RLR) for recurrent ICC. Methods Between 1997 and 2012, clinical data and outcomes of 125 consecutive patients undergoing liver resection for ICC were retrospectively analyzed. Results The rate of R0 resection was 89% (n = 110). Overall median survival was 35 months, and 1-, 3-, and 5-year actuarial survival rates were 80%, 48%, and 28%, respectively. Recurrence occurred in 76 patients (63.5%) and was intrahepatic only for 39 patients (51%). Tumor size greater than 5 cm was identified as an independent risk factor for recurrence ( P ≤ .0001). RLR for recurrent ICC was feasible in 10 patients (25%) with a median survival after recurrence of 25 months (16 to 76). Conclusions Tumor size more than 5 cm represents an independent risk factor for recurrence after resection of ICC. RLR in case of recurrent ICC, when feasible, is associated with longer overall survival.read more
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Surgical options for intrahepatic cholangiocarcinoma.
TL;DR: The epidemiology and staging of intrahepatic cholangiocarcinoma is reviewed and the selection of surgical modalities and postoperative outcomes of ICC patients are highlighted via literature review.
Journal ArticleDOI
Effectiveness of repeat hepatic resection for patients with recurrent intrahepatic cholangiocarcinoma: Factors associated with long-term outcomes
Anfeng Si,Jun Li,Xianglei Xing,Zhengqing Lei,Yong Xia,Zhenlin Yan,Kui Wang,Lehua Shi,Feng Shen +8 more
TL;DR: In this paper, the authors evaluated the short and long-term prognoses of patients after repeat hepatic resection for recurrent intrahepatic cholangiocarcinoma.
Journal ArticleDOI
Surgical Resection for Recurrent Intrahepatic Cholangiocarcinoma
TL;DR: Patients who underwent repeated resections had a significant better OS compared to those receiving chemotherapy, transarterial chemoembolization, selective internal radiotherapy, radiofrequency ablation or best supportive care and should be considered as long as resection is technically possible.
Journal ArticleDOI
Long-Term Survival of Recurrent Intrahepatic Cholangiocarcinoma: The Impact and Selection of Repeat Surgery.
Tomoaki Yoh,Etsuro Hatano,Satoru Seo,Yukihiro Okuda,Hiroaki Fuji,Yoshinobu Ikeno,Kojiro Taura,Kentaro Yasuchika,Hideaki Okajima,Toshimi Kaido,Shinji Uemoto +10 more
TL;DR: Repeat surgery for recurrent ICC with an appropriate selection can be associated with prolonged survival and the feasibility, nodal status, number of tumors on the primary tumor, and time to recurrence may be considered as selection criteria.
Journal ArticleDOI
Surgical management of recurrent intrahepatic cholangiocarcinoma: predictors, adjuvant chemotherapy, and surgical therapy for recurrence: A multi-institutional study by the Kyushu Study Group of Liver Surgery.
Yo-ichi Yamashita,Ken Shirabe,Toru Beppu,Susumu Eguchi,Atsushi Nanashima,Masayuki Ohta,Shinichi Ueno,Kazuhiro Kondo,Kenji Kitahara,Masayuki Shiraishi,Yuko Takami,Tomoaki Noritomi,Kohji Okamoto,Yoshito Ogura,Hideo Baba,Hikaru Fujioka +15 more
TL;DR: Predictors of the recurrence of intrahepatic cholangiocarcinoma (ICC) and the survival benefit of adjuvant chemotherapy and surgical treatment for ICC recurrence were identified and primary im+ should be considered a contraindication for surgical treatment in patients without primary im.
References
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Journal ArticleDOI
Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States.
TL;DR: There has been a marked increase in the incidence and mortality from intrahepatic cholangiocarcinoma in the United States in recent years, and this tumor continues to be associated with a poor prognosis.
Journal ArticleDOI
Nomenclature of hepatic anatomy and resections: a review of the Brisbane 2000 system.
TL;DR: The Brisbane 2000 system of nomenclature of hepatic anatomy and resections was introduced to provide a universal terminology in an area that was plagued by confusing and inappropriate terminology.
Journal ArticleDOI
Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968-1998.
Simon D. Taylor-Robinson,Mireille B. Toledano,S Arora,Thomas Keegan,S Hargreaves,Angus J. Beck,Shahid A. Khan,Paul Elliott,Howard C. Thomas +8 more
TL;DR: The observed increase in mortality from intrahepatic cholangiocarcinoma may represent better case ascertainment and diagnosis due to improved diagnostic imaging, use of image guided biopsies, or increased use of ERCP.
Journal ArticleDOI
Intrahepatic Cholangiocarcinoma: Resectability, Recurrence Pattern, and Outcomes
Sharon M. Weber,William R. Jarnagin,David S. Klimstra,Ronald P. DeMatteo,Yuman Fong,Leslie H. Blumgart +5 more
TL;DR: Although complete resection improved survival, recurrence was common and the majority of recurrences were local or regional, which may help guide future adjuvant therapy strategies.
Journal ArticleDOI
Recurrence After Operative Management of Intrahepatic Cholangiocarcinoma
Omar Hyder,Ioannis Hatzaras,Georgios C. Sotiropoulos,Andreas Paul,Sorin Alexandrescu,Hugo Marques,Carlo Pulitano,Eduardo Barroso,Bryan M. Clary,Luca Aldrighetti,Cristina R. Ferrone,Andrew X. Zhu,Todd W. Bauer,Dustin M. Walters,Ryan T. Groeschl,T. Clark Gamblin,J. Wallis Marsh,Kevin Nguyen,Ryan S. Turley,Irinel Popescu,Catherine Hubert,Stephanie Meyer,Michael A. Choti,Jean-François Gigot,Gilles Mentha,Timothy M. Pawlik +25 more
TL;DR: Recurrence after operative intervention for ICC was common and disease recurred both at intra- and extrahepatic sites with roughly the same frequency, factors such as lymph node metastasis, tumor size, and vascular invasion predict highest risk of recurrence.
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