Journal ArticleDOI
Focal phospholipases A2 group III injections induce cervical white matter injury and functional deficits with delayed recovery concomitant with Schwann cell remyelination.
TLDR
The results indicate that sPLA(2)-III can create white matter pathologies that are remyelinated by Schwann cells 2 to 3 weeks after injury, and is the first report of a reaching task being able to discriminate between various grades of cervical white matter damage and varying extents of recovery.About:
This article is published in Experimental Neurology.The article was published on 2007-09-01. It has received 38 citations till now. The article focuses on the topics: Schwann cell & Spinal cord.read more
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Phospholipases A2 and Inflammatory Responses in the Central Nervous System
TL;DR: The goal for this review is to better understand the structure and function of these PLA2s and to highlight specific types of PLA2S and their cross-talk mechanisms in these inflammatory responses under physiological and pathological conditions in the CNS.
Journal ArticleDOI
A Novel Growth-Promoting Pathway Formed by GDNF-Overexpressing Schwann Cells Promotes Propriospinal Axonal Regeneration, Synapse Formation, and Partial Recovery of Function after Spinal Cord Injury
Ling-Xiao Deng,Ping Deng,Yiwen Ruan,Zao Cheng Xu,Nai-Kui Liu,Xuejun Wen,George M. Smith,Xiao Ming Xu +7 more
TL;DR: It is demonstrated that a growth-promoting pathway, extending from the axonal cut ends to the site of innervation in the distal spinal cord, promoted regeneration of DPSN axons through and beyond the lesion gap of a spinal cord hemisection.
Journal ArticleDOI
Restoring Cellular Energetics Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury.
Qi Han,Yuxiang Xie,Josue D. Ordaz,Andrew Huh,Ning Huang,Wei Wu,Nai-Kui Liu,Kelly A. Chamberlain,Zu-Hang Sheng,Xiao Ming Xu +9 more
TL;DR: It is revealed that enhancing axonal mitochondrial transport by deleting syntaphilin (Snph) recovers injury-induced mitochondrial depolarization and suggests that enhancing mitochondrial transport and cellular energetics are promising strategies to promote regeneration and functional restoration after CNS injuries.
Journal ArticleDOI
Oligodendroglial impact on axonal function and survival - a hypothesis.
TL;DR: Experimental and pathological findings point to a primary role of myelinating glia in long-term axonal support and suggest that defects of lipid metabolism in oligodendrocytes contribute to inflammatory myelin diseases.
Journal ArticleDOI
Impact of Bee Venom Enzymes on Diseases and Immune Responses.
TL;DR: This review gathers all the current knowledge on BV enzymes and their specific mechanisms in regulating various immune responses and physiological changes to provide a basis for future therapies for various diseases.
References
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Journal ArticleDOI
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
TL;DR: The effects of dominant-interfering or constitutively activated forms of various components of the JNK-p38 and ERK signaling pathways demonstrated that activation of JNK and p38 and concurrent inhibition of ERK are critical for induction of apoptosis in these cells.
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The expanding superfamily of phospholipase A(2) enzymes: classification and characterization.
David A. Six,Edward A. Dennis +1 more
TL;DR: This review updates the classification of the various PLA(2)'s now described in the literature, and expands or realignment of Groups VI, VII and VIII, as well as the addition of Group XIPLA(2) from plants.
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An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks
TL;DR: It is concluded that the SFI provides a simple, accurate, reliable, and repeatable method for evaluating the functional condition of sciatic nerve in rats.
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Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal
Kirsten Lauber,Erwin Bohn,Stefan M Kröber,Yi Jin Xiao,Sibylle G. Blumenthal,Ralph K. Lindemann,P. Marini,Carolin A. Wiedig,Anke Zobywalski,Shairaz Baksh,Yan Xu,Ingo B. Autenrieth,Klaus Schulze-Osthoff,Claus Belka,Gernot Stuhler,Sebastian Wesselborg +15 more
TL;DR: Evidence is presented that apoptotic cells secrete chemotactic factor(s) that stimulate the attraction of monocytic cells and primary macrophages and that lysophosphatidylcholine was released from apoptotic Cells due to the caspase-3 mediated activation of the calcium-independent phospholipase A(2).
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Phospholipase A2 enzymes
Ichiro Kudo,Makoto Murakami +1 more
TL;DR: The secretory PLA2 (sPLA2) family, in which 10 isozymes have been identified, consists of low-molecular weight, Ca2+-requiring secretory enzymes that have been implicated in a number of biological processes, such as modification of eicosanoid generation, inflammation, and host defense.