Frailty and Mortality in Kidney Transplant Recipients
Mara McAdams-DeMarco,Mara McAdams-DeMarco,Andrew Law,Elizabeth A. King,Elizabeth A. King,Babak J. Orandi,Babak J. Orandi,Megan L. Salter,Megan L. Salter,Natasha Gupta,Eric K.H. Chow,Nada Alachkar,Niraj M. Desai,Ravi Varadhan,Jeremy D. Walston,Dorry L. Segev,Dorry L. Segev +16 more
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TLDR
Regardless of age, frailty is a strong, independent risk factor for post‐KT mortality, even after carefully adjusting for many confounders using a novel, efficient statistical approach.About:
This article is published in American Journal of Transplantation.The article was published on 2015-01-01 and is currently open access. It has received 258 citations till now. The article focuses on the topics: Transplantation & Proportional hazards model.read more
Citations
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Journal ArticleDOI
Frailty: implications for clinical practice and public health.
Emiel O. Hoogendijk,Jonathan Afilalo,Kristine E. Ensrud,Paul Kowal,Graziano Onder,Linda P. Fried +5 more
TL;DR: An overview of the global impact and burden of frailty, the usefulness of the frailty concept in clinical practice, potential targets for frailty prevention, and directions that need to be explored in the future are provided.
Journal ArticleDOI
Development of a novel frailty index to predict mortality in patients with end-stage liver disease
Jennifer C. Lai,Kenneth E. Covinsky,Jennifer L. Dodge,W. John Boscardin,Dorry L. Segev,John P. Roberts,Sandy Feng +6 more
TL;DR: The frailty index for patients with cirrhosis, comprised of three performance‐based metrics, has construct validity for the concept of frailty and improves risk prediction of waitlist mortality over MELDNa alone.
Journal ArticleDOI
KDIGO Clinical Practice Guideline on the evaluation and management of candidates for kidney transplantation
Steven J. Chadban,Curie Ahn,David A. Axelrod,Bethany J. Foster,Bertram L. Kasiske,Vijah Kher,Deepali Kumar,Rainer Oberbauer,Julio Pascual,Helen Pilmore,James R. Rodrigue,Dorry L. Segev,Neil S. Sheerin,Kathryn Tinckam,Germaine Wong,Gregory A. Knoll +15 more
TL;DR: The goal is to assist the clinical team to assimilate all data relevant to an individual, consider this within their local health context, and make an overall judgment on candidacy for transplantation.
Journal ArticleDOI
Frailty Phenotypes, Disability, and Outcomes in Adult Candidates for Lung Transplantation.
Jonathan P. Singer,Joshua M. Diamond,Cynthia J. Gries,J. McDonnough,Paul D. Blanc,Rupal J. Shah,Monica Y. Dean,Beverly L Hersh,Paul J. Wolters,Sofya Tokman,Selim M. Arcasoy,Kristy Ramphal,John R. Greenland,Nancy Smith,Pricilla Heffernan,Lori Shah,Pavan Shrestha,Jeffrey A. Golden,Nancy P. Blumenthal,Debbie Huang,Joshua R. Sonett,Steven R. Hays,Michelle Oyster,Patricia P. Katz,Hilary Robbins,M. Brown,Lorriana E. Leard,Jasleen Kukreja,Matthew Bacchetta,Errol L. Bush,Frank D'Ovidio,Melanie Rushefski,Kashif Raza,Jason D. Christie,David J. Lederer +34 more
TL;DR: Frailty is prevalent among lung transplant candidates and is independently associated with greater disability and an increased risk of delisting or death.
Journal ArticleDOI
Report from the American Society of Transplantation on frailty in solid organ transplantation
Jon A. Kobashigawa,Darshana Dadhania,Sangeeta Bhorade,Deborah Adey,Joseph R. Berger,Geetha Bhat,Marie Budev,Andres Duarte-Rojo,Michael A. Dunn,Shelley A. Hall,Meera N. Harhay,Kirsten L. Johansen,Susan M. Joseph,Cassie C. Kennedy,Evan P. Kransdorf,Krista L. Lentine,Raymond J. Lynch,Mara McAdams-DeMarco,Shunji Nagai,Michael Olymbios,Jignesh Patel,Sean Pinney,Joanna Schaenman,Dorry L. Segev,Palak Shah,Lianne G. Singer,Jonathan P. Singer,Christopher J. Sonnenday,Puneeta Tandon,Elliot B. Tapper,Stefan G. Tullius,Michael E. Wilson,Martin R. Zamora,Jennifer C. Lai +33 more
TL;DR: This conference achieved its intent to highlight the importance of frailty in organ transplantation and to plant the seeds for further discussion and research in this field.
References
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Frailty in Older Adults Evidence for a Phenotype
Linda P. Fried,Catherine M. Tangen,Jeremy D. Walston,Anne B. Newman,Calvin H. Hirsch,John S. Gottdiener,Teresa E. Seeman,Russell P. Tracy,Willem J. Kop,B Gregory Burke,Mary Ann McBurnie +10 more
TL;DR: This study provides a potential standardized definition for frailty in community-dwelling older adults and offers concurrent and predictive validity for the definition, and finds that there is an intermediate stage identifying those at high risk of frailty.
Journal Article
Cardiovascular Health Study Collaborative Research Group : Frailty in older adults : evidence for a phenotype
Journal ArticleDOI
Frailty as a Predictor of Surgical Outcomes in Older Patients
Martin A. Makary,Dorry L. Segev,Peter J. Pronovost,Dora Syin,Karen Bandeen-Roche,Purvi Patel,Ryan K. Takenaga,Lara Devgan,Christine G. Holzmueller,Jing Tian,Linda P. Fried +10 more
TL;DR: Frailty independently predicts postoperative complications, length of stay, and discharge to a skilled or assisted-living facility in older surgical patients and enhances conventional risk models.
Journal ArticleDOI
Phenotype of Frailty: Characterization in the Women's Health and Aging Studies
Karen Bandeen-Roche,Qian Li Xue,Luigi Ferrucci,Jeremy D. Walston,Jack M. Guralnik,Paulo H.M. Chaves,Scott L. Zeger,Linda P. Fried +7 more
TL;DR: The frailty definition developed in the CHS is applicable across diverse population samples and identifies a profile of high risk of multiple adverse outcomes and is consistent with the widely held theory that conceptualizes frailty as a syndrome.
Journal ArticleDOI
Frailty and Activation of the Inflammation and Coagulation Systems With and Without Clinical Comorbidities Results From the Cardiovascular Health Study
Jeremy D. Walston,Mary Ann McBurnie,Anne B. Newman,Russell P. Tracy,Willem J. Kop,Calvin H. Hirsch,John S. Gottdiener,Linda P. Fried +7 more
TL;DR: The hypothesis that there is a specific physiological basis to the geriatric syndrome of frailty that is characterized in part by increased inflammation and elevated markers of blood clotting is supported and that these physiological differences persist when those with diabetes and cardiovascular disease are excluded.
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