Journal ArticleDOI
Free radicals, antioxidant enzymes, and carcinogenesis
Reads0
Chats0
TLDR
Free radicals are found to be involved in both initiation and promotion of multistage carcinogenesis, and antioxidants, the free radical scavengers, are shown to be anticarcinogens.About:
This article is published in Free Radical Biology and Medicine.The article was published on 1990-01-01. It has received 1085 citations till now. The article focuses on the topics: Glutathione peroxidase & Antioxidant.read more
Citations
More filters
Journal ArticleDOI
Oxidative Stress, Inflammation, and Cancer: How Are They Linked?
TL;DR: Observations to date suggest that oxidative stress, chronic inflammation, and cancer are closely linked.
Journal ArticleDOI
Oxidative stress and gene regulation.
R.G Allen,Maria Tresini +1 more
TL;DR: The discussion presented here provides a tabular summary of many of the redox effects on gene expression and signaling pathways that are currently known to exist, and highlights the growing number of pathways shown to be dependent on oxidation or antioxidation.
Journal ArticleDOI
Oxidative stress: from basic research to clinical application.
TL;DR: Current evidence in clinical research does not show unequivocal distinction between causal or associative relationships of pro-oxidants to the disease process.
Journal ArticleDOI
Persistent oxidative stress in cancer
TL;DR: It is suggested that the concept of ‘persistent oxidative stress in cancer’ may open up a new research area, explaining part of the characteristic tumor biology of cancer such as activated transcription factors and proto‐oncogenes, genomic instability, chemotherapy‐resistance, invasion and metastasis.
Journal ArticleDOI
Redox regulation of transcriptional activators
Yi Sun,Larry W. Oberley +1 more
TL;DR: Differential regulation of these transcriptional activators, which in turn, regulate many target/effector genes, may provide an additional mechanism by which small antioxidant molecules play protective roles in anticancer and antiaging processes.
References
More filters
Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.
Journal ArticleDOI
Hydroperoxide metabolism in mammalian organs.
Journal ArticleDOI
A simple method for clinical assay of superoxide dismutase.
Yi Sun,L. W. Oberley,Ying Li +2 more
TL;DR: The Cu,ZnSOD concentrations in serum and plasma of patients with cancer of the large intestine tended to be less and greater than these values, respectively, but not statistically significantly so.
Journal ArticleDOI
Superoxide Radical and Superoxide Dismutases
TL;DR: O2- oxidizes the [4Fe-4S] clusters of dehydratases, such as aconitase, causing-inactivation and release of Fe(II), which may then reduce H2O2 to OH- +OH..