Journal ArticleDOI
From endothelial dysfunction to atherosclerosis
Simona Sitia,Livio Tomasoni,Fabiola Atzeni,Giuseppe Ambrosio,C. Cordiano,Alberico L. Catapano,Simona Tramontana,Francesco Perticone,P. Naccarato,Paolo G. Camici,Eugenio Picano,Lauro Cortigiani,M. Bevilacqua,Laura Milazzo,Daniele Cusi,Cristina Barlassina,Piercarlo Sarzi-Puttini,Maurizio Turiel +17 more
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TLDR
The most important aspects of the pathogenesis and development of endothelial dysfunction are summarized, with particular attention to the role of traditional CV risk factors, the usefulness of vasoreactivity tests, and the future perspectives opened by genetic studies.About:
This article is published in Autoimmunity Reviews.The article was published on 2010-10-01. It has received 438 citations till now. The article focuses on the topics: Endothelial dysfunction & Endothelium.read more
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Immunomodulation and Anti-Inflammatory Effects of Garlic Compounds
Rodrigo Arreola,Saray Quintero-Fabián,Rocío Ivette López-Roa,Enrique Octavio Flores-Gutierrez,Juan Pablo Reyes-Grajeda,Lucrecia Carrera-Quintanar,Daniel Ortuño-Sahagún +6 more
TL;DR: The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the homeostasis of the immune system as discussed by the authors.
Journal ArticleDOI
Inflammation as "common soil" of the multifactorial diseases.
TL;DR: The data emerged from research on inflammatory mediators sustaining multifactorial diseases is discussed, which appears to be supported by tissue malfunction or homeostatic imbalance in a wide variety of conditions.
Journal ArticleDOI
Vascular aspects of multiple sclerosis
TL;DR: Three types of vascular dysfunction have been described in multiple sclerosis (MS), and data suggest that a subtype of focal MS lesions might have an ischaemic origin, and there seems to be a link between reduced white matter perfusion and cognitive dysfunction in MS.
Journal ArticleDOI
Plasma Klotho and Cardiovascular Disease in Adults
Richard D. Semba,Anne R. Cappola,Kai Sun,Stefania Bandinelli,Mansi Dalal,Candace Crasto,Jack M. Guralnik,Luigi Ferrucci +7 more
TL;DR: Whether plasma klotho, a recently discovered hormone that has been implicated in atherosclerosis, is related to prevalent cardiovascular disease (CVD) in adults is investigated.
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Purified Anthocyanin Supplementation Improves Endothelial Function via NO-cGMP Activation in Hypercholesterolemic Individuals
Yanna Zhu,Min Xia,Yan Yang,Fengqiong Liu,Zhongxia Li,YuanTao Hao,Mantian Mi,Tianru Jin,Wenhua Ling +8 more
TL;DR: Anthocyanin supplementation improves endothelium-dependent vasodilation in hypercholesterolemic individuals and involves activation of the NO-cGMP signaling pathway, improvements in the serum lipid profile, and decreased inflammation.
References
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Journal ArticleDOI
The immune response in atherosclerosis: a double-edged sword
Göran K. Hansson,Peter Libby +1 more
TL;DR: This Review focuses on the role of immune mechanisms in the formation and activation of atherosclerotic plaques, and also includes a discussion of the use of inflammatory markers for predicting cardiovascular events.
Book
Coronary Microvascular Dysfunction
Paolo G. Camici,Filippo Crea +1 more
TL;DR: This review discusses the pathogenesis and management of coronary microvascular dysfunction and factors to consider in clinical management are the cause of the dysfunction and whether it is iatrogenic, whether obstructive coronary artery disease is present, and whether myocardial disease ispresent.
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Endothelial Function Cardiac Events
Amir Lerman,Andreas M. Zeiher +1 more
TL;DR: The present review is focused on the potential underlying mechanism by which endothelial dysfunction may contribute to cardiovascular events, and the localization and distribution of the endothelial cell layer.
Journal ArticleDOI
Epigenetic epidemiology of the developmental origins hypothesis.
TL;DR: It is suggested that strategies for future human epidemiologic studies to identify causal associations between early exposures, long-term changes in epigenetic regulation, and disease, which may ultimately enable specific early-life interventions to improve human health, are suggested.
Journal ArticleDOI
Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage
TL;DR: It is proposed DNA damage and late onset disease are consequences of a triage allocation response to micronutrient scarcity, and it is hypothesize that short-term survival was achieved by allocating scarcemicronutrients by triage, in part through an adjustment of the binding affinity of proteins for required micronsutrients.