Journal ArticleDOI
Fructose-induced modifications of myoglobin: Change of structure from met (Fe3+) to oxy (Fe2+) form.
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TLDR
Structural modifications of metmyoglobin after short-term and long-term glycation by fructose appeared to modify Arg139 to arg-pyrimidine, which exhibited antioxidative activity and might be involved in the conversion of met (Fe3+) to oxy (Fe2+) form of myoglobin.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2011-01-01. It has received 26 citations till now. The article focuses on the topics: Metmyoglobin & Myoglobin.read more
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Structure and function of heme proteins regulated by diverse post-translational modifications.
TL;DR: The tremendous progress made in research methods and advances in research techniques will make it possible to rationally control the diverse PTMs of heme proteins, especially those associated with human diseases, toward the authors' desired goals for a better life.
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Methylglyoxal-induced modifications of hemoglobin: structural and functional characteristics.
TL;DR: The modified protein was found to be more effective than HbA(0) in H(2)O(2)-mediated iron release and oxidative damages involving Fenton reaction and may enhance oxidative stress and associated complications, particularly in diabetes mellitus with increased level of MG.
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Methylglyoxal-induced modification causes aggregation of myoglobin
TL;DR: MG-derived AGEs may have an important role as the precursors of protein aggregation, which, in turn, may be associated with physiological complications.
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Mechanism of antiglycating properties of syringic and chlorogenic acids in in vitro glycation system
TL;DR: This paper tries to demonstrate how syringic and chlorogenic acids, two largely consumed natural products bind with BSA to prevent glycation-associated complications.
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Ribose sugars generate internal glycation cross-links in horse heart myoglobin.
TL;DR: The study shows the unique nature of these common pentose sugars in spontaneous glycation reactions with proteins, and the modification is likely due to an internal cross-link formed during a glycation reaction involving the N-terminus and an internal amine group.
References
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Journal ArticleDOI
PROCHECK: a program to check the stereochemical quality of protein structures
TL;DR: The PROCHECK suite of programs as mentioned in this paper provides a detailed check on the stereochemistry of a protein structure and provides an assessment of the overall quality of the structure as compared with well refined structures of the same resolution.
Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function
Garrett M. Morris,David S. Goodsell,Robert Scott Halliday,Ruth Huey,William E. Hart,Richard K. Belew,Arthur J. Olson +6 more
TL;DR: It is shown that both the traditional and Lamarckian genetic algorithms can handle ligands with more degrees of freedom than the simulated annealing method used in earlier versions of AUTODOCK, and that the Lamarckia genetic algorithm is the most efficient, reliable, and successful of the three.
Journal ArticleDOI
Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E.
TL;DR: The phosphomolybdenum method is routinely applied in the laboratory to evaluate the total antioxidant capacity of plant extracts and to determine vitamin E in a variety of grains and seeds, including corn and soybean.
Journal ArticleDOI
Antioxidant activity of various tea extracts in relation to their antimutagenicity
Gow-Chin Yen,Hui-Yin Chen +1 more
TL;DR: The relationship between antioxidant activity and antimutagenicity of various tea extracts (green tea, pouchong tea, oolong tea and black tea) was investigated in this article, which showed that all tea extracts exhibited markedly antioxidant activity.
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Site-selective modifications of arginine residues in human hemoglobin induced by methylglyoxal.
Yuan Gao,Yinsheng Wang +1 more