Journal ArticleDOI
Functional differentiation in the hippocampus
May-Britt Moser,Edvard I. Moser +1 more
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In primates, the posterior hippocampus (corresponding to the dorsal hippocampus of rodents) appears to be more important than anterior areas for encoding of spatial memory and certain forms of nonspatial memory.Abstract:
The hippocampus is critically involved in certain kinds of memory. During memory formation, it may operate as an integrated unit, or isolated parts may be responsible for different functions. Recent evidence suggests that the hippocampus is functionally differentiated along its dorsoventral (septotemporal) axis. The cortical and subcortical connections of the dorsal and ventral hippocampus are different, with information derived from the sensory cortices entering mainly in the dorsal two-thirds or three-quarters of the dentate gyrus. Rats can acquire a spatial navigation task if small tissue blocks are spared within this region, but equally large blocks at the ventral end are not capable of supporting spatial learning. In primates, the posterior hippocampus (corresponding to the dorsal hippocampus of rodents) appears to be more important than anterior areas for encoding of spatial memory and certain forms of nonspatial memory. The ventral (or anterior) hippocampal formation is to some extent disconnected from the rest of the structure both in terms of intrahippocampal and extrahippocampal connections and may be performing functions that are qualitatively different from, and independent of, those of the dorsal hippocampal formation.read more
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Genome-wide atlas of gene expression in the adult mouse brain
Ed S. Lein,Michael Hawrylycz,Nancy Ao,Mikael Ayres,Amy Bensinger,Amy Bernard,Andrew F. Boe,Mark S. Boguski,Mark S. Boguski,Kevin S. Brockway,Emi J. Byrnes,Lin Chen,Li Chen,Tsuey-Ming Chen,Mei Chi Chin,Jimmy Chong,Brian E. Crook,Aneta Czaplinska,Chinh Dang,Suvro Datta,Nick Dee,Aimee L. Desaki,Tsega Desta,Ellen Diep,Tim A. Dolbeare,Matthew J. Donelan,Hong-Wei Dong,Jennifer G. Dougherty,Ben J. Duncan,Amanda Ebbert,Gregor Eichele,Lili K. Estin,Casey Faber,Benjamin A.C. Facer,Rick Fields,Shanna R. Fischer,Tim P. Fliss,Cliff Frensley,Sabrina N. Gates,Katie J. Glattfelder,Kevin R. Halverson,Matthew R. Hart,John G. Hohmann,Maureen P. Howell,Darren P. Jeung,Rebecca A. Johnson,Patrick T. Karr,Reena Kawal,Jolene Kidney,Rachel H. Knapik,Chihchau L. Kuan,James H. Lake,Annabel R. Laramee,Kirk D. Larsen,Christopher Lau,Tracy Lemon,Agnes J. Liang,Ying Liu,Lon T. Luong,Jesse Michaels,Judith J. Morgan,Rebecca J. Morgan,Marty Mortrud,Nerick Mosqueda,Lydia Ng,Randy Ng,Geralyn J. Orta,Caroline C. Overly,Tu H. Pak,Sheana Parry,Sayan Dev Pathak,Owen C. Pearson,Ralph B. Puchalski,Zackery L. Riley,Hannah R. Rockett,Stephen A. Rowland,Joshua J. Royall,Marcos J. Ruiz,Nadia R. Sarno,Katherine Schaffnit,Nadiya V. Shapovalova,Taz Sivisay,Clifford R. Slaughterbeck,Simon Smith,Kimberly A. Smith,Bryan I. Smith,Andy J. Sodt,Nick N. Stewart,Kenda-Ruth Stumpf,Susan M. Sunkin,Madhavi Sutram,Angelene Tam,Carey D. Teemer,Christina Thaller,Carol L. Thompson,Lee R. Varnam,Axel Visel,Axel Visel,Ray M. Whitlock,Paul Wohnoutka,Crissa K. Wolkey,Victoria Y. Wong,Matthew J.A. Wood,Murat B. Yaylaoglu,Rob Young,Brian L. Youngstrom,Xu Feng Yuan,Bin Zhang,Theresa A. Zwingman,Allan R. Jones +109 more
TL;DR: An anatomically comprehensive digital atlas containing the expression patterns of ∼20,000 genes in the adult mouse brain is described, providing an open, primary data resource for a wide variety of further studies concerning brain organization and function.
Journal ArticleDOI
Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures
TL;DR: Behavior, anatomical, and gene expression studies that together support a functional segmentation into three hippocampal compartments are reviewed, finding gene expression in the dorsal hippocampus correlates with cortical regions involved in information processing, while genes expressed in the ventral hippocampus correlate with regions involved with emotion and stress.
Book
Preventing Mental, Emotional, and Behavioral Disorders Among Young People: Progress and Possibilities
TL;DR: Mental, emotional, and behavioral (MEB) disorders—which include depression, conduct disorder, and substance abuse—affect large numbers of young people.
Journal ArticleDOI
Regional dissociations within the hippocampus--memory and anxiety.
David M. Bannerman,J. N. P. Rawlins,Stephen B. McHugh,Robert M. J. Deacon,Benjamin K. Yee,Tobias Bast,Wei-Ning Zhang,Helen H. J. Pothuizen,Joram Feldon +8 more
TL;DR: Gray and McNaughton's theory can in principle incorporate these apparently distinct hippocampal functions, and provides a plausible unitary account for the multiple facets of hippocampal function.
Journal ArticleDOI
Functional organization of the hippocampal longitudinal axis
TL;DR: Together, anatomical studies and electrophysiological recordings in rodents suggest a model in which functional long-axis gradients are superimposed on discrete functional domains, which provides a potential framework to explain and test the multiple functions ascribed to the hippocampus.
References
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The Hippocampus as a Cognitive Map
John O'Keefe,Lynn Nadel +1 more
TL;DR: The amnesic syndrome is presented as an extension of the theory to humans and the role of operators in the locale system is examined.
Journal ArticleDOI
Loss of recent memory after bilateral hippocampal lesions.
TL;DR: The results of these studies point to the importance of the hippocampal complex for normal memory function in patients who had undergone similar, but less radical, bilateral medial temporallobe resections, and as a warning to others of the risk to memory involved in bilateral surgical lesions of the hippocampusal region.
Journal ArticleDOI
Place navigation impaired in rats with hippocampal lesions.
TL;DR: It is reported that, in addition to a spatial discrimination impairment, total hippocampal lesions also cause a profound and lasting placenavigational impairment that can be dissociated from correlated motor, motivational and reinforcement aspects of the procedure.
Journal ArticleDOI
The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
TL;DR: Preliminary observations on the behaviour of hippocampusal units in the freely moving rat provide support for this theory of hippocampal function.
Journal ArticleDOI
Simple memory: a theory for archicortex.
TL;DR: It is shown that rather general numerical constraints roughly determine the dimensions of memorizing models for the mammalian brain, and from these is derived a general model for archicortex.