Gene expression and angiotropism in primary CNS lymphoma
James L. Rubenstein,Jane Fridlyand,Arthur Shen,Kenneth Aldape,David G. Ginzinger,Tracy T. Batchelor,Patrick A. Treseler,Mitchel S. Berger,Michael T. McDermott,Michael D. Prados,Jon Karch,Craig Okada,William C. Hyun,Seema Parikh,Christopher M. Haqq,Marc A. Shuman +15 more
TLDR
It is demonstrated that interleukin-4 (IL-4) is expressed by tumor vasculature as well as by tumor cells in CNS lymphomas, and high expression of activated STAT6 in tumors was associated with short survival in an independent set of patients with primary CNS lymphoma who were treated with high-dose intravenous methotrexate therapy.About:
This article is published in Blood.The article was published on 2006-05-01 and is currently open access. It has received 195 citations till now. The article focuses on the topics: Lymphoma & REL.read more
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The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Primary central nervous system lymphoma.
TL;DR: The differential diagnosis of PCNSL includes central nervous system gliomas, metastatic tumors, demyelinating disorders, subacute infarcts, and space-occupied lesions due to an infectious etiology.
Journal ArticleDOI
Intensive Chemotherapy and Immunotherapy in Patients With Newly Diagnosed Primary CNS Lymphoma: CALGB 50202 (Alliance 50202)
James L. Rubenstein,Eric D. Hsi,Jeffrey L. Johnson,Sin-Ho Jung,Megan O. Nakashima,Barbara Grant,Bruce D. Cheson,Lawrence D. Kaplan +7 more
TL;DR: It is demonstrated for the first time to the authors' knowledge that dose-intensive consolidation for PCNSL is feasible in the multicenter setting and yields rates of PFS and OS at least comparable to those of regimens involving WBRT.
Journal ArticleDOI
Primary Vitreoretinal Lymphoma: A Report from an International Primary Central Nervous System Lymphoma Collaborative Group Symposium
Chi-Chao Chan,James L. Rubenstein,Sarah E. Coupland,Janet L. Davis,J. William Harbour,Patrick B. Johnston,Nathalie Cassoux,Nathalie Cassoux,Valérie Touitou,Justine R. Smith,Tracy T. Batchelor,Jose S. Pulido +11 more
TL;DR: Because of the disease rarity, international, multicenter, collaborative efforts are required to better understand the biology and pathogenesis of PVRL as well as to define both diagnostic markers and optimal therapies.
Journal ArticleDOI
Phase I Study of Intraventricular Administration of Rituximab in Patients With Recurrent CNS and Intraocular Lymphoma
James L. Rubenstein,Jane Fridlyand,Lauren E. Abrey,Arthur Shen,Jon Karch,Endi Wang,Samar Issa,Lloyd E. Damon,Michael D. Prados,Michael T. McDermott,Joan M. O'Brien,Christopher M. Haqq,Marc A. Shuman +12 more
TL;DR: In this article, the authors conducted a phase I dose-escalation study of intrathecal rituximab monotherapy in patients with recurrent CNS non-Hodgkin's lymphoma (NHL).
References
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Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
Journal ArticleDOI
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Ash A. Alizadeh,Michael B. Eisen,R. Eric Davis,Izidore S. Lossos,Andreas Rosenwald,Jennifer C. Boldrick,Hajeer Sabet,Truc Tran,Xin Yu,John Powell,Liming Yang,Gerald E. Marti,Troy Moore,James I. Hudson,Li-Sheng Lu,David B. Lewis,Robert Tibshirani,Gavin Sherlock,Wing C. Chan,Timothy C. Greiner,Dennis D. Weisenburger,James O. Armitage,Roger A. Warnke,Ronald Levy,Wyndham H. Wilson,M. R. Grever,John C. Byrd,David Botstein,Patrick O. Brown,Louis M. Staudt +29 more
TL;DR: It is shown that there is diversity in gene expression among the tumours of DLBCL patients, apparently reflecting the variation in tumour proliferation rate, host response and differentiation state of the tumour.
Journal ArticleDOI
R: A Language for Data Analysis and Graphics
Ross Ihaka,Robert Gentleman +1 more
TL;DR: In this article, the authors discuss their experience designing and implementing a statistical computing language, which combines what they felt were useful features from two existing computer languages, and they feel that the new language provides advantages in the areas of portability, computational efficiency, memory management, and scope.
Journal ArticleDOI
Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation
TL;DR: This article proposes normalization methods that are based on robust local regression and account for intensity and spatial dependence in dye biases for different types of cDNA microarray experiments.
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