Journal ArticleDOI
Genetic polymorphisms of alcohol metabolizing enzymes.
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TLDR
Recent advances in the understanding of the functional polymorphisms of ADH, ALDH and CYP2E1 and their metabolic, physiologic and clinical correlations are presented.About:
This article is published in Pathologie Biologie.The article was published on 2001-01-01. It has received 157 citations till now. The article focuses on the topics: Alcohol dehydrogenase & Ethanol metabolism.read more
Citations
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‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?
George Davey Smith,Shah Ebrahim +1 more
TL;DR: Mendelian randomization provides new opportunities to test causality and demonstrates how investment in the human genome project may contribute to understanding and preventing the adverse effects on human health of modifiable exposures.
Journal Article
Overview: how is alcohol metabolized by the body?
TL;DR: Alcohol is eliminated from the body by various metabolic mechanisms, and variations in the genes for these enzymes have been found to influence alcohol consumption, alcohol-related tissue damage, and alcohol dependence.
Journal ArticleDOI
Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health.
TL;DR: The human health risks from clinical and animal research studies are reviewed, including aldehydes as haptens in allergenic hypersensitivity diseases, respiratory allergies, and idiosyncratic drug toxicity; the potential carcinogenic risks of the carbonyl body burden.
Journal ArticleDOI
Herb-drug interactions: a literature review.
Zeping Hu,Xiaoxia Yang,Paul C. Ho,Sui Yung Chan,Paul Wan Sia Heng,Eli Chan,Wei Duan,Hwee-Ling Koh,Shu-Feng Zhou +8 more
TL;DR: An extensive review of the literature identified reported herb-drug interactions with clinical significance, although the underlying mechanisms for the altered drug effects and/or concentrations by concomitant herbal medicines are yet to be determined.
Journal ArticleDOI
Innovative preparation of curcumin for improved oral bioavailability.
Hiroki Sasaki,Yoichi Sunagawa,Yoichi Sunagawa,Kenji Takahashi,Atsushi Imaizumi,Hiroyuki Fukuda,Tadashi Hashimoto,Hiromichi Wada,Yasufumi Katanasaka,Hideaki Kakeya,Masatoshi Fujita,Koji Hasegawa,Tatsuya Morimoto +12 more
TL;DR: THERACURMIN exhibited an inhibitory action against alcohol intoxication after drinking in humans, as evidenced by the reduced acetaldehyde concentration of the blood, and shows a much higher bioavailability than currently available preparations.
References
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Journal ArticleDOI
Distribution of ADH2 and ALDH2 genotypes in different populations
H. W. Goedde,Dharam P. Agarwal,G. Fritze,Doris Meier-Tackmann,Surjit Singh,G. Beckmann,Kuldeep Bhatia,L. Z. Chen,Bingliang Fang,R. Lisker,Y. K. Paik,Francisco Rothhammer,Nilmani Saha,B. Segal,L. M. Srivastava,A. Czeizel +15 more
TL;DR: The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians and this mutant gene was finding to be widely prevalent among the Mongoloids.
Journal ArticleDOI
Human aldehyde dehydrogenase gene family
TL;DR: The phylogenic tree constructed of 56 ALDH sequences of humans, animals, fungi, protozoa and eubacteria, suggests that the present-day human ALDH genes were derived from four ancestral genes that existed prior to the divergence of Eubacteria and Eukaryotes.
Journal ArticleDOI
Interaction between the Functional Polymorphisms of the Alcohol-Metabolism Genes in Protection against Alcoholism
Chiao Chicy Chen,Ru Band Lu,Yi Chyan Chen,Ming-Fang Wang,Yue-Cune Chang,Ting-Kai Li,Shih Jiun Yin +6 more
TL;DR: It is suggested that protection afforded by the ADH2*2 allele may be independent of that afforded by ALDH2* 2, and that individuals carrying one or two copies of ADH 2 and a single copy of ALDH 2*2 had the lowest risk for alcoholism, as compared with the ADh2*1/*1 and ALDH1*1 genotype.
Journal ArticleDOI
Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review.
TL;DR: Enhanced ethanol oxidation is associated with cross-induction of the metabolism of other drugs, resulting in drug tolerance, and there is increased conversion of known hepatotoxic agents (such as CCl4) to toxic metabolites, which may explain the enhanced susceptibility of alcoholics to the adverse effects of industrial solvents.
Journal ArticleDOI
Racial differences in alcohol sensitivity: A new hypothesis
TL;DR: The data suggest that the initial alcohol sensitivity in Japanese might be due to a delayed oxidation of acetaldehyde rather than its higher than normal production by atypical alcohol dehydrogenase.
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