Journal ArticleDOI
Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism.
William F. Bosron,Ting-Kai Li +1 more
TLDR
Variant isoenzymes produced at the two polymorphic alcohol dehydrogenase loci account for the differences in enzyme electrophoretic patterns observed among individuals, and this may accounts for the 2‐ to 3‐fold variation in alcohol elimination rate among individuals.About:
This article is published in Hepatology.The article was published on 1986-05-01. It has received 562 citations till now. The article focuses on the topics: Alcohol dehydrogenase & ADH1B.read more
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Recent Developments in Alcoholism
TL;DR: The chapter will discuss the genetic epidemiology of alcoholism in women, with evidence presented that suggests the existence of two forms of Alcoholism in women: one more environmentally determined and one more influenced by genetic mediation.
Journal ArticleDOI
Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology
TL;DR: The strongest correlations found to date have been those between the ALDH2*2 allele and cancers of the oro-pharynx and oesophagus, and it will be important to replicate other interesting associations between these variants and other cancers and heart disease, and to determine the biochemical mechanisms underlying the associations.
Journal ArticleDOI
Extrahepatic Metabolism of Drugs in Humans
TL;DR: The metabolic profile and sites of enzymatic reactions for each drug should be determined and extrahepatic metabolism has been demonstrated for numerous drugs.
Journal ArticleDOI
Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics.
Akira Yokoyama,Taro Muramatsu,Tai Ohmori,Tetsuji Yokoyama,Keiji Okuyama,Hisao Takahashi,Yoshio Hasegawa,Susumu Higuchi,Katsuya Maruyama,Katsuyuki Shirakura,Hiromasa Ishii +10 more
TL;DR: A general role of acetaldehyde, a recognized animal carcinogen, in the development of human cancers is suggested, including liver or other cancers prevalent in Japanese alcoholics.
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Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach.
TL;DR: The hypothesis that alcohol intake has a marked effect on blood pressure and the risk of hypertension is supported.
References
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Journal ArticleDOI
Inheritance of alcohol abuse. Cross-fostering analysis of adopted men
TL;DR: The inheritance of alcoholism was studied in 862 Swedish men adopted by nonrelatives at an early age and found that both the congenital and postnatal backgrounds of the adoptees modify their risk for alcohol abuse.
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Alcohol Problems in Adoptees Raised Apart From Alcoholic Biological Parents
TL;DR: It is suggested that genetic factors may play a role in the development of alcohol problems in men separated from their biological parents early in life where one parent had a hospital diagnosis of alcoholism.
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Maternal inheritance of alcohol abuse. Cross-fostering analysis of adopted women.
TL;DR: There was a threefold excess of alcohol abusers among the adopted daughters of alcoholic biological mothers compared with other daughters, confirming the heterogeneity among alcoholics noted in earlier work with adopted sons, which found that the latter type of criminal alcoholics also had no excess of alcoholic mothers.
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Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals
TL;DR: It is concluded that a point mutation in the human ALDH2 locus produced the glutamine leads to lysine substitution and enzyme inactivation in atypical livers.