Glycosylation and oligomerization of the spike protein of marburg virus
Reads0
Chats0
TLDR
The oligosaccharide side chains of the glycoprotein of Marburg virus have been analyzed by determining their sensitivity to enzymatic degradation and their reactivity with lectins and found that they consist of N- and O-glycans.About:
This article is published in Virology.The article was published on 1991-05-01 and is currently open access. It has received 122 citations till now. The article focuses on the topics: Marburg virus & Marburgvirus.read more
Citations
More filters
Journal ArticleDOI
A system for functional analysis of Ebola virus glycoprotein
Ayato Takada,Clinton S. Robison,Hideo Goto,Anthony Sanchez,K. Gopal Murti,Michael A. Whitt,Yoshihiro Kawaoka +6 more
TL;DR: It is suggested that cell surface glycoproteins with N-linked oligosaccharide chains contribute to the entry of Ebola viruses, presumably acting as a specific receptor and/or cofactor for virus entry.
Journal ArticleDOI
Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients.
Sylvain Baize,Eric M. Leroy,Marie-Claude Georges-Courbot,Monique Capron,J. Lansoud-Soukate,Patrice Debré,Susan P. Fisher-Hoch,Joseph B. McCormick,Alain J. Georges +8 more
TL;DR: Comparing the immune responses of patients who died from Ebola virus disease with those who survived during two large outbreaks in 1996 in Gabon suggests events very early in Ebola virus infection determine the control of viral replication and recovery or catastrophic illness and death.
Journal ArticleDOI
Processing of the Ebola virus glycoprotein by the proprotein convertase furin
TL;DR: It is considered that proteolytic processing of GP may be an important determinant for the pathogenicity of Ebola virus.
Journal ArticleDOI
Comparison of the Transcription and Replication Strategies of Marburg Virus and Ebola Virus by Using Artificial Replication Systems
TL;DR: To compare the replication and transcription strategies of both viruses, an artificial replication system based on the vaccinia virus T7 expression system was established for EBOV and it was observed that neither MBGV nor E BOV were able to replicate the heterologous minigenomes.
Journal ArticleDOI
Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain.
TL;DR: The structure suggests that fusion peptides near the N termini form disulfide-bonded loops at one end of the molecule and that the C-terminal membrane anchors are at the same end.
References
More filters
Journal Article
Haemolytic disease of the new born.
TL;DR: Comparative Aspects of Hæmolytic Disease of the Newborn by G. Fulton Roberts and W. Heinemann are compared.
Journal ArticleDOI
Isolation and partial characterisation of a new virus causing acute hæmorrhagic fever in zaire
Journal ArticleDOI
O-linked oligosaccharides are acquired by herpes simplex virus glycoproteins in the Golgi apparatus.
D C Johnson,Patricia G. Spear +1 more
TL;DR: It is concluded that extension of O-linked oligosaccharide chains on HSV1 glycoproteins, and probably also attachment of the first O- linked sugars, occurs as a late posttranslational modification in the Golgi apparatus.
Journal ArticleDOI
Descriptive analysis of Ebola virus proteins
TL;DR: The virion proteins of two strains of Ebola virus were compared by SDS-polyacrylamide gel electrophoresis (PAGE) and radioimmunoprecipitation (RIP).