Journal ArticleDOI
Growth factors and cancer
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TLDR
Signaling pathways that mediate the normal functions of growth factors are commonly subverted in cancer, and oncogenes appear to replace the actions of one set of these growth factors.Abstract:Â
Signaling pathways that mediate the normal functions of growth factors are commonly subverted in cancer. Oncogenes identified by a variety of approaches have been shown to function at critical steps in mitogenic signaling. Progression through the cell cycle requires the coordinated actions of members of two complementary classes of growth factors, and oncogenes appear to replace the actions of one set of these growth factors. Growth factors can also influence normal cell differentiation, and constitutive activation of growth-promoting pathways in cancer cells can modulate the cell phenotype as well. Paracrine actions of growth factors and cytokines may also influence the stepwise series of genetic events that lead to malignancy. New approaches for cancer therapy are being developed that intervene at various steps in growth factor signaling pathways.read more
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Journal ArticleDOI
Multinational Study of the Efficacy and Safety of Humanized Anti-HER2 Monoclonal Antibody in Women Who Have HER2-Overexpressing Metastatic Breast Cancer That Has Progressed After Chemotherapy for Metastatic Disease
Melody A. Cobleigh,Charles L. Vogel,Debasish Tripathy,Nicholas J. Robert,Susy Scholl,Louis Fehrenbacher,Janet M. Wolter,Virginia Paton,Steven Shak,Gracie Lieberman,Dennis J. Slamon +10 more
TL;DR: Recombinant humanized anti-HER2 monoclonal antibody, administered as a single agent, produces durable objective responses and is well tolerated by women with HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease.
Journal ArticleDOI
Epidermal growth factor-related peptides and their receptors in human malignancies
Journal ArticleDOI
Epidermal growth factor receptor (EGFR) signaling in cancer
Nicola Normanno,Antonella De Luca,Caterina Bianco,Luigi Strizzi,Mario Mancino,Monica R. Maiello,Adele Carotenuto,Gianfranco De Feo,Francesco Caponigro,David S. Salomon +9 more
TL;DR: The growth and the survival of carcinoma cells appear to be sustained by a network of receptors/ligands of the ErbB family, which is important for therapeutic approaches, since the response to anti-EGFR agents might depend on the total level of expression ofErbB receptors and ligands in tumor cells.
Journal ArticleDOI
Phase II Trial of Cetuximab in Patients With Refractory Colorectal Cancer That Expresses the Epidermal Growth Factor Receptor
Leonard B. Saltz,Neal J. Meropol,Patrick J. Loehrer,Michael N. Needle,Justin Kopit,Robert J. Mayer +5 more
TL;DR: Cetuximab on this once-weekly schedule has modest activity and is well-tolerated as a single agent in patients with chemotherapy-refractory colorectal cancer whose tumors express the epidermal growth factor receptor.
Journal ArticleDOI
Emergent Properties of Networks of Biological Signaling Pathways
Upinder S. Bhalla,Ravi Iyengar +1 more
TL;DR: Biochemical signaling networks were constructed with experimentally obtained constants and analyzed by computational methods to understand their role in complex biological processes and raise the possibility that information for "learned behavior" of biological systems may be stored within intracellular biochemical reactions that comprise signaling pathways.
References
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Journal ArticleDOI
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
Dennis J. Slamon,Gary M. Clark,Steven G. Wong,Wendy J. Levin,Axel Ullrich,William L. McGuire +5 more
TL;DR: Amplification of the HER-2/neu gene was a significant predictor of both overall survival and time to relapse in patients with breast cancer, and had greater prognostic value than most currently used prognostic factors in lymph node-positive disease.
Book
Cancer : Principles and Practice of Oncology
TL;DR: Part I: Molecular Biology of Cancer Molecular Methods in Oncology Section 1. Amplification Techniques Section 2. RNA Interference Section 3. cDNA arrays Section 4. Tissue arrays Section 5. Cytogenetics Section 6. Bioinformatics Genomics and Proteomics Molecular Targets in oncology.
Journal ArticleDOI
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer.
Dennis J. Slamon,William Godolphin,Lovell A. Jones,John A. Holt,Steven G. Wong,Duane E. Keith,Wendy J. Levin,Susan G. Stuart,Judy Udove,Axel Ullrich,Michael F. Press +10 more
TL;DR: The concept that the HER-2/neu gene may be involved in the pathogenesis of some human cancers, including breast and ovarian cancer, is supported.
Journal ArticleDOI
Signal transduction by receptors with tyrosine kinase activity
Axel Ullrich,Joseph Schlessinger +1 more
TL;DR: Cet article synthese montre comment des recepteurs membranaires a activite tyrosine kinase peuvent etre impliques dans la transduction and notamment jouent le role de signal de the transduction.
Journal Article
ras Oncogenes in Human Cancer: A Review
TL;DR: It appeared that ras gene mutations can be found in a variety of tumor types, although the incidence varies greatly and some evidence that environmental agents may be involved in the induction of the mutations.
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