Journal ArticleDOI
Guidelines and Cost Analysis for Catalyst Production in Biocatalytic Processes
TLDR
It is seen that the fermentation yield in terms of final achievable cell concentration and expression level as well as the production scale are crucial for decreasing the total cost contribution of the biocatalyst.About:
This article is published in Organic Process Research & Development.The article was published on 2011-01-21. It has received 395 citations till now. The article focuses on the topics: Total cost.read more
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Role of Biocatalysis in Sustainable Chemistry
Roger A. Sheldon,John M. Woodley +1 more
TL;DR: Based on the principles and metrics of green chemistry and sustainable development, biocatalysis is both a green and sustainable technology and its broader application will be further stimulated in the future by the emerging biobased economy.
Journal ArticleDOI
Biocatalysis in Organic Chemistry and Biotechnology: Past, Present, and Future
TL;DR: This Perspective focuses on developments which have popularized enzymes as part of the toolkit of synthetic organic chemists and biotechnologists, including a discussion of the scope and limitation of cascade reactions using enzyme mixtures in vitro and of metabolic engineering of pathways in cells as factories for the production of simple compounds such as biofuels and complex natural products.
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Microbial Enzymes: Tools for Biotechnological Processes
José L. Adrio,Arnold L. Demain +1 more
TL;DR: Microbial diversity and modern molecular techniques are being used to discover new microbial enzymes whose catalytic properties can be improved/modified by different strategies based on rational, semi-rational and random directed evolution.
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Evaluation of immobilized enzymes for industrial applications
Andreas Liese,Lutz Hilterhaus +1 more
TL;DR: This tutorial review the focus is set on the evaluation of immobilized enzymes in respect to mass transport limitations, immobilization yield and stability, to enable industrial applications.
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Industrial applications of immobilized enzymes—A review
Alessandra Basso,Simona Serban +1 more
TL;DR: A series of large-scale applications of immobilized enzymes with benefits for the food, chemical, pharmaceutical, cosmetics and medical device industries, some of which have been scarcely reported on previously are presented.
References
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Industrial biocatalysis today and tomorrow
TL;DR: Biocatalytic processes can now be carried out in organic solvents as well as aqueous environments, so that apolar organic compounds aswell as water-soluble compounds can be modified selectively and efficiently with enzymes and bioc atalytically active cells.
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High cell-density culture of Escherichia coli
TL;DR: The problems encountered in HCDC of E. coli are reviewed, various solutions are discussed, and feeding strategies for HCDC are described.
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Dispelling the myths--biocatalysis in industrial synthesis.
TL;DR: Expect many new industrial applications of biocatalysis to be realized, from single-step enzymatic conversions to customized multistep microbial synthesis by means of metabolic pathway engineering.
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The production of fine chemicals by biotransformations.
TL;DR: An analysis of 134 industrial biotransformations reveals that hydrolases and redox biocatalysts are the most prominent categories and the implications of this for future research and development onBiocatalysis are discussed.
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Biocatalysis for pharmaceutical intermediates: the future is now
David Pollard,John M. Woodley +1 more
TL;DR: This review describes how demands are being addressed to make biocatalysis successful, particularly by the use of micro-scale technology for high-speed catalyst screening and process development alongside discipline integration of biology and engineering with chemistry.