Journal ArticleDOI
Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents.
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TLDR
The goal with this document was to assimilate the scarce data that exist and present it within an evidencebased framework in order to provide treatment guidelines.Abstract:
Practice guidelines for physicians who treat children with brain trauma are long overdue. A significant barrier to producing guidelines has been the lack of data from well-designed, controlled studies that address each specific juncture of the acute treatment phase. Our goal with this document was to assimilate the scarce data that exist and present it within an evidencebased framework in order to provide treatment guidelines. With topics for which there were no evidence-based data, we worked as a group to achieve consensus and provided treatment options. To accomplish this, we assembled a multidisciplinary team of clinicians and researchers, keeping in mind that the presence of multiple perspectives would minimize bias. Although we recognize that this list is not complete, it represents a multidisciplinary group of clinicians and scientists with considerable expertise in key areas relevant to the project. We consider this work a “document in progress” and are committed to its ongoing revision and to incorporating additional areas of expertise that may not currently be represented. It is our goal that these guidelines be used to distinguish important areas of research, so that future revisions will contain more substantial evidence. A number of acknowledgments must beread more
Citations
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Journal ArticleDOI
Moderate and severe traumatic brain injury in adults.
TL;DR: New developments and current knowledge and controversies, focusing on moderate and severe TBI in adults, are summarised, with an emphasis on epidemiological monitoring, trauma organisation, and approaches to management.
Book ChapterDOI
Traumatic brain injury.
TL;DR: In childhood, traumatic brain injury poses the unique challenges of an injury to a developing brain and the dynamic pattern of recovery over time, so the treatment needs to be multifaceted and starts at the scene of the injury and extends into the home and school.
Journal ArticleDOI
Guidelines for prehospital management of traumatic brain injury 2nd edition.
Neeraj Badjatia,Nancy Carney,Todd J. Crocco,Mary E. Fallat,Halim Hennes,Andy Jagoda,Sarah C. Jernigan,Peter B. Letarte,E. Brooke Lerner,Thomas Moriarty,Peter T. Pons,Scott M. Sasser,Thomas M. Scalea,Charles L. Schelein,David W. Wright +14 more
TL;DR: These Guidelines are distributed with the understanding that the Brain Trauma Foundation, the National Highway Traffic Safety Administration, and the other organizations that have collaborated in the development of these Guidelines are not engaged in rendering professional medical services.
Journal ArticleDOI
Phase II clinical trial of moderate hypothermia after severe traumatic brain injury in children
P. David Adelson,John Ragheb,Paul M. Kanev,Douglas L. Brockmeyer,Sue R. Beers,S. Danielle Brown,Laura D. Cassidy,Yuefang Chang,Harvey S. Levin +8 more
TL;DR: Moderate hypothermia after severe TBI in children was found to be safe relative to standard management and NORM in children of all ages and in children with delay of initiation of treatment up to 24 hours, and functional outcome tended to improve from the 3- to 6-month cognitive assessment in HYPO compared with NORM.
Journal ArticleDOI
Epidemiology and outcomes of pediatric traumatic brain injury
TL;DR: Neuropsychological and behavioral outcomes for injured children vary with the severity of injury, child age at injury, premorbid child characteristics, family factors and the families’ socioeconomic status; each of these factors needs to be taken into account when designing rehabilitation strategies and assessing factors related to outcome.
References
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Journal ArticleDOI
Guidelines for the management of severe head injury. Brain Trauma Foundation.
Ross Bullock,Randall M. Chesnut,G. Clifton,Jamshid Ghajar,D. W. Marion,Raj K. Narayan,David W. Newell,L. H. Pitts,M. J. Rosner,J. W. Wilberger +9 more
Journal ArticleDOI
Prevention of secondary ischemic insults after severe head injury.
Claudia S. Robertson,Alex B. Valadka,H. Hannay,Charles F. Contant,Shankar P. Gopinath,Manuela Cormio,Masahiko Uzura,Robert G. Grossman +7 more
TL;DR: In this paper, the authors compared the effects of two acute care management strategies on the frequency of jugular venous desaturation and refractory intracranial hypertension and on long-term neurologic outcome in patients with severe head injury.
Journal ArticleDOI
High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury
Howard M. Eisenberg,Ralph F. Frankowski,Charles F. Contant,Lawrence F. Marshall,Michael D. Walker +4 more
TL;DR: The hypothesis that high-dose pentobarbital is an effective adjunctive therapy, but that it is indicated in only a small subset of patients with severe head injury is supported.
Journal ArticleDOI
Diffuse cerebral swelling following head injuries in children: the syndrome of “malignant brain edema”
Derek A. Bruce,Abass Alavi,Larissa T. Bilaniuk,Carol A. Dolinskas,Walter D. Obrist,Barbara Uzzell +5 more
TL;DR: The commonest initial computerized tomography (CT) finding in head-injured children is bilateral diffuse cerebral swelling, and the clinical history, course, and outcome of 63 children with this CT pattern are reviewed.
Journal ArticleDOI
A Phase II Study of Moderate Hypothermia in Severe Brain Injury
Guy L. Clifton,Steven J. Allen,Patricia Barrodale,P. M. Plenger,James M. Berry,Stephen M. Koch,Jack M. Fletcher,Ronald L. Hayes,Sung C. Choi +8 more
TL;DR: In this paper, the Glasgow Coma Scale (GCS) was used to evaluate brain injury patients with severe non-penetrating brain injury (NCI) and the two groups were balanced in terms of age (Wilcoxon's rank sum test, p > 0.95), randomizing GCS, p = 0.54, and primary diagnosis.
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