Hepatopulmonary Syndrome: A Nationwide Analysis of Epidemiological Trends and Outcomes From 2012 to 2018.
Dushyant Singh Dahiya,Asim Kichloo,Hafeez Shaka,Jagmeet P. Singh,Gurdeep Singh,Farah Wani,Sundas Masudi,Hazique Koul,Sailaja Pisipati +8 more
TLDR
In this article, the authors analyzed data from the Nationwide Inpatient Sample (NIS) for the years 2012, 2014, 2016 and 2018 to identify adult (≥ 18 years) hospitalizations with a diagnosis of hepatopulmonary syndrome (HPS).Abstract:
Background This study was designed to determine the epidemiological trends and adverse outcomes of hepatopulmonary syndrome (HPS). Methods This retrospective interrupted trend study analyzed data from the Nationwide Inpatient Sample (NIS) for the years 2012, 2014, 2016 and 2018 to identify adult (≥ 18 years) hospitalizations with a diagnosis of HPS. We highlighted epidemiological trends for HPS. Inpatient mortality, mean length of stay (LOS) and mean total hospital charge (THC) were estimated using multivariate regression trend analysis. Results We observed an increase in the total number of HPS hospitalizations from 1,565 in 2012 to 2,495 in 2018, with mean age ranging from 55.8 to 58.1 years. There was a trend towards increasing hospitalizations (P-trend < 0.001) with increasing mean age (P-trend = 0.003) for HPS. Whites made up most of the study population. The inpatient mortality for HPS ranged from 12.4% to 12.6%, but there was no statistically significant trend for mortality (P-trend = 0.534) between 2012 and 2018. Additionally, there was no change in both mean LOS (P-trend = 0.545) and mean THC (P-trend = 0.534) for HPS for these years. Conclusions Hospitalizations and mean age for HPS were on the rise. Inpatient mortality ranged from 12.4% to 12.6%; however, a statistically significant trend for mortality was absent.read more
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[Hepatopulmonary syndrome].
TL;DR: In this article , a triad of liver disease and portal hypertension, evidence of IPVDs, and impaired gas exchange (alveolar-arterial oxygen difference [A-aO2]≥15mmHg) was used to diagnose the hepatopulmonary syndrome (HPS).
Journal ArticleDOI
Syndrome hépato-pulmonaire
TL;DR: In this article , a triad of liver disease and portal hypertension, evidence of IPVDs, and impaired gas exchange (alveolar-arterial oxygen difference [A-aO2]≥15mmHg) was used to diagnose the hepatopulmonary syndrome (HPS).
References
More filters
Journal ArticleDOI
Pulmonary–Hepatic vascular Disorders (PHD)
TL;DR: A number of alterations, both directly and indirectly related to hepatic injury and portal hypertension, result in the production or release of mediators into the venous circulation, where they influence the pulmonary microcirculation in experimental hepatopulmonary syndrome.
Journal ArticleDOI
The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017 : a systematic analysis for the Global Burden of Disease Study 2017
Sadaf G. Sepanlou,Saeid Safiri,Catherine Bisignano,Kevin S Ikuta,Shahin Merat,Mehdi Saberifiroozi,Hossein Poustchi,Derrick Tsoi,Danny V. Colombara,Amir Abdoli,Rufus A. Adedoyin,Mohsen Afarideh,Sutapa Agrawal,Sohail Ahmad,Elham Ahmadian,Ehsan Ahmadpour,Tomi Akinyemiju,Chisom Joyqueenet Akunna,Vahid Alipour,Amir Almasi-Hashiani,Abdulaziz M. Almulhim,Rajaa Al-Raddadi,Nelson Alvis-Guzman,Nahla Anber,Colin Angus,Amir Anoushiravani,Jalal Arabloo,Ephrem Mebrahtu Araya,Daniel Asmelash,Bahar Ataeinia,Zerihun Ataro,Maha Atout,Floriane Ausloos,Ashish Awasthi,Alaa Badawi,Maciej Banach,Diana Fernanda Bejarano Ramirez,Akshaya Srikanth Bhagavathula,Neeraj Bhala,Krittika Bhattacharyya,Antonio Biondi,Srinivasa Rao Bolla,Archith Boloor,Antonio Maria Borzì,Zahid A Butt,Luis Camera,Ismael R. Campos-Nonato,Félix Carvalho,Dinh-Toi Chu,Sheng Chia Chung,Paolo Cortesi,Vera Marisa Costa,Benjamin C Cowie,Ahmad Daryani,Barbora de Courten,Gebre Teklemariam Demoz,Rupak Desai,Samath D Dharmaratne,Shirin Djalalinia,Hoa Thi Do,Fariba Dorostkar,Thomas M Drake,Manisha Dubey,Bruce Bartholow Duncan,Andem Effiong,Aziz Eftekhari,Aisha Elsharkawy,Arash Etemadi,Mohammad Farahmand,Farshad Farzadfar,Eduarda Fernandes,Irina Filip,Florian Fischer,Ketema Bizuwork Bizuwork Gebremedhin,Birhanu Geta,Syed Amir Gilani,Paramjit Gill,Reyna Alma Gutirrez,Michael Tamene Haile,Arvin Haj-Mirzaian,Saeed Hamid,Milad Hasankhani,Amir Hasanzadeh,Maryam Hashemian,Hamid Yimam Hassen,Simon I. Hay,Khezar Hayat,Behnam Heidari,Andualem Henok,Chi Linh Hoang,Mihaela Hostiuc,Sorin Hostiuc,Vivian Chia-Rong Hsieh,Ehimario U. Igumbor,Olayinka Stephen Ilesanmi,Seyed Sina Naghibi Irvani,Nader Jafari Balalami,Spencer L. James,Panniyammakal Jeemon,Ravi Prakash Jha,Jost B. Jonas,Jacek Jerzy Jozwiak,Ali Kabir,Amir Kasaeian,Hagazi Gebremedhin Kassaye,Adane Teshome Kefale,Rovshan Khalilov,Muhammad Ali Khan,Ejaz Ahmad Khan,Amir Khater,Yun Jin Kim,Ai Koyanagi,Carlo La Vecchia,Lee Ling Lim,Alan D. Lopez,Stefan Lorkowski,Paulo A. Lotufo,Rafael Lozano,Muhammed Magdy Abd El Razek,Hue Thi Mai,Navid Manafi,Amir Manafi,Mohammad Ali Mansournia,Lorenzo G. Mantovani,Giampiero Mazzaglia,Dhruv Mehta,Walter Mendoza,Ritesh G. Menezes,Melkamu Merid Mengesha,Tuomo J. Meretoja,Tomislav Mestrovic,Bartosz Miazgowski,Ted R. Miller,Erkin M. Mirrakhimov,Prasanna Mithra,Babak Moazen,Masoud Moghadaszadeh,Abdollah Mohammadian-Hafshejani,Shafiu Mohammed,Ali H. Mokdad,Pablo Montero-Zamora,Ghobad Moradi,Mukhammad David Naimzada,Vinod C Nayak,Ionut Negoi,Trang Huyen Nguyen,Richard Ofori-Asenso,In-Hwan Oh,Tinuke O Olagunju,Jagadish Rao Padubidri,Keyvan Pakshir,Adrian Pana,Mona Pathak,Akram Pourshams,Navid Rabiee,Amir Radfar,Alireza Rafiei,Kiana Ramezanzadeh,Saleem Muhammad Rana,Salman Rawaf,David Laith Rawaf,Robert C. Reiner,Leonardo Roever,Robin Room,Gholamreza Roshandel,Saeed Safari,Abdallah M. Samy,Juan Sanabria,Benn Sartorius,Maria Inês Schmidt,Subramanian Senthilkumaran,Masood Ali Shaikh,Mehdi Sharif,Amrollah Sharifi,Mika Shigematsu,Jasvinder A. Singh,Amin Soheili,Hafiz Ansar Rasul Suleria,Berhane Fseha Teklehaimanot,Berhe Etsay Tesfay,Marco Vacante,Amir Vahedian-Azimi,Pascual R. Valdez,Tommi Vasankari,Giang Thu Vu,Yasir Waheed,Kidu Gidey Weldegwergs,A. Werdecker,Ronny Westerman,Dawit Zewdu Wondafrash,Adam Belay Wondmieneh,Yordanos Gizachew Yeshitila,Naohiro Yonemoto,Chuanhua Yu,Zoubida Zaidi,Afshin Zarghi,Shira Zelber-Sagi,Kaleab Alemayehu Zewdie,Zhi Jiang Zhang,Xiu Ju Zhao,Mohsen Naghavi,Reza Malekzadeh +201 more
TL;DR: Mortality, prevalence, and DALY estimates are compared with those expected according to the Socio-demographic Index (SDI) as a proxy for the development status of regions and countries, and a significant increase in age-standardised prevalence rate of decompensated cirrhosis between 1990 and 2017.
Journal ArticleDOI
Natural history of hepatopulmonary syndrome: Impact of liver transplantation.
TL;DR: In conclusion, hypoxemia of HPS is frequently progressive and as OLT outcome relates to pretransplantation PaO2, additional MELD points should advance the priority for OLT in HPS.
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Prognostic significance of the hepatopulmonary syndrome in patients with cirrhosis
Peter Schenk,Maximilian Schöniger-Hekele,Valentin Fuhrmann,Christian Madl,Gerd R. Silberhumer,Christian Müller +5 more
TL;DR: The presence of HPS independently worsens prognosis of patients with cirrhosis and should influence patient management and scoring systems and accelerate the evaluation process for liver transplantation.
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Adjusting Health Expenditures for Inflation: A Review of Measures for Health Services Research in the United States
TL;DR: There is no single gold standard for adjusting health expenditures for inflation, so suggestions on specific indexes to use in many common situations and general guidance in others are developed.