Herpesviral Latency-Common Themes.
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TLDR
Three criteria have been set forth to define latency and differentiate it from persistent or abortive infection: 1) persistence of the viral genome, 2) limited viral gene expression with no viral particle production, and 3) the ability to reactivate to a lytic cycle.Abstract:
Latency establishment is the hallmark feature of herpesviruses, a group of viruses, of which nine are known to infect humans. They have co-evolved alongside their hosts, and mastered manipulation of cellular pathways and tweaking various processes to their advantage. As a result, they are very well adapted to persistence. The members of the three subfamilies belonging to the family Herpesviridae differ with regard to cell tropism, target cells for the latent reservoir, and characteristics of the infection. The mechanisms governing the latent state also seem quite different. Our knowledge about latency is most complete for the gammaherpesviruses due to previously missing adequate latency models for the alpha and beta-herpesviruses. Nevertheless, with advances in cell biology and the availability of appropriate cell-culture and animal models, the common features of the latency in the different subfamilies began to emerge. Three criteria have been set forth to define latency and differentiate it from persistent or abortive infection: 1) persistence of the viral genome, 2) limited viral gene expression with no viral particle production, and 3) the ability to reactivate to a lytic cycle. This review discusses these criteria for each of the subfamilies and highlights the common strategies adopted by herpesviruses to establish latency.read more
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References
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Journal ArticleDOI
Identification of Virus-Encoded MicroRNAs
Sébastien Pfeffer,Mihaela Zavolan,Friedrich A. Grässer,Minchen Chien,James J. Russo,Jingyue Ju,Bino John,Anton J. Enright,Debora S. Marks,Chris Sander,Thomas Tuschl +10 more
TL;DR: The small RNA profile of cells infected by Epstein-Barr virus is recorded and it is shown that EBV expresses several microRNA (miRNA) genes, which are identified viral regulators of host and/or viral gene expression.
Journal ArticleDOI
Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells
TL;DR: It is shown that circular DNAs containing oriP, the EBNA-1 gene and a selectable marker replicate autonomously in cells derived from at at least four developmental lineages and from at least three species.
Journal ArticleDOI
Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture.
Rolf Renne,Weidong Zhong,Brian G. Herndier,Michael S. McGrath,Nancy W. Abbey,Dean H. Kedes,Don Ganem +6 more
TL;DR: The development of a system for the lytic growth of this virus in a latently infected B cell line and the first ultrastructural visualization of the virus are reported, which will facilitate the detailed study of the molecular biology of viral replication, the testing of antiviral drugs and the development of diagnostic tests for viral infection.
Journal ArticleDOI
RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons.
TL;DR: In initial attempts to define the molecular events responsible for the latent state of herpes simplex virus, in situ hybridization was utilized to search for virally encoded RNA transcripts in latently infected sensory neurons, finding only RNA transcripts hybridizing to the ICP-0 probe were detected.
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