High-throughput continuous-flow system for SABRE hyperpolarization.
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TLDR
A new design of a polarizing system is reported, which can be used to prepare a continuous flow of SABRE-hyperpolarized sample with a considerable throughput of several millilitres per second and a rapid delivery into an NMR instrument, and opens the possibilities for SABre experiments requiring a long-term, stable and high level of nuclear polarization.About:
This article is published in Journal of Magnetic Resonance.The article was published on 2019-01-14 and is currently open access. It has received 24 citations till now. The article focuses on the topics: Hyperpolarization (physics).read more
Citations
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NMR-based metabolomics and fluxomics: developments and future prospects.
TL;DR: Advanced developments to make NMR metabolomics more resolutive, more sensitive and more accessible are described, as well as new approaches to improve the identification of biomarkers.
Journal ArticleDOI
15N MRI of SLIC‐SABRE Hyperpolarized 15N‐Labelled Pyridine and Nicotinamide
Alexandra Svyatova,Ivan V. Skovpin,Nikita V. Chukanov,Kirill V. Kovtunov,Eduard Y. Chekmenev,Eduard Y. Chekmenev,Andrey N. Pravdivtsev,Jan-Bernd Hövener,Igor V. Koptyug +8 more
TL;DR: It is demonstrated for the first time that radio-frequency-based SABRE hyperpolarization techniques can be used to obtain 15 N MRI of biomolecule 1-15 N-nicotinamide and two image acquisition strategies were utilized and compared.
Journal ArticleDOI
Spin Hyperpolarization in Modern Magnetic Resonance
James Eills,Dmitry Budker,Silvia Cavagnero,Eduard Y. Chekmenev,Stuart J. Elliott,Sami Jannin,Anne Lesage,Jörg Matysik,Thomas Meersmann,Thomas F. Prisner,Jeffrey A. Reimer,Hanming Yang,Igor V. Koptyug +12 more
TL;DR: A review of spin hyperpolarization can be found in this article , where the authors provide a unified picture of the many methods and techniques that fall under the umbrella term "hyperpolarisation" but are currently seldom perceived as integral parts of the same field.
Journal ArticleDOI
Open-source, partially 3D-printed, high-pressure (50-bar) liquid-nitrogen-cooled parahydrogen generator
TL;DR: In this paper, the authors provide the blueprints and 3D models as open-source for a low-cost (EUR ) 50-bar liquid-nitrogen-cooled p H 2 generator.
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Automated pneumatic shuttle for magnetic field cycling and parahydrogen hyperpolarized multidimensional NMR.
TL;DR: A simple-to-implement pneumatic sample shuttle system that enables automated 2D hyperpolarized NMR, including the first inverse 15N/1H HSQC, and uncovers binding mechanisms of the catalytic species through cross peaks that are not accessible in standard one-dimensional hyperPolarized experiments.
References
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Jan Henrik Ardenkjær-Larsen,Björn Fridlund,Andreas Gram,Georg Hansson,Lennart Hansson,Mathilde H. Lerche,Rolf Servin,Mikkel Thaning,Klaes Golman +8 more
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Thorsten Maly,Galia T. Debelouchina,Vikram S. Bajaj,Kan-Nian Hu,Chan-Gyu Joo,Melody L. Mak-Jurkauskas,Jagadishwar R. Sirigiri,Patrick C.A. van der Wel,Judith Herzfeld,Richard J. Temkin,Robert G. Griffin +10 more
TL;DR: This review focuses on recent developments in the field of DNP with a special emphasis on work done at high magnetic fields (> or =5 T), the regime where contemporary NMR experiments are performed.
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Parahydrogen and synthesis allow dramatically enhanced nuclear alignment
TL;DR: The PASADENA effect as mentioned in this paper is a method for transient high-sensitivity proton spin-labelling by molecular addition of dihydrogen, which can be converted to magnetization observable by NMR.
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Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer
Ralph W. Adams,Juan A. Aguilar,Kevin D. Atkinson,Michael J. Cowley,Paul I. P. Elliott,Simon B. Duckett,Gary G. R. Green,Iman G. Khazal,Joaquín López-Serrano,David C. Williamson +9 more
TL;DR: It is shown here that a metal complex can facilitate the reversible interaction of para-hydrogen with a suitable organic substrate such that up to an 800-fold increase in proton, carbon, and nitrogen signal strengths are seen for the substrate without its hydrogenation.