Journal ArticleDOI
Highly potent anti-malarial activity of benzopyrano(4,3-b)benzopyran derivatives and in silico interaction analysis with putative target Plasmodium falciparum lactate dehydrogenase.
Nishant Joshi,Rahul S. Hada,Sonal Gupta,Sonal Gupta,Juveria Khan,Jeremy C. Dobrowolski,Pawan K. Dhar,Naresh Kumar,Shailja Singh +8 more
TLDR
In this article, a rapid increase in resistance to existing drugs has posed an urgent problem for the treatment of Malaria infection caused by Plasmodium falciparum.Abstract:
Malaria infection caused by Plasmodium falciparum is majorly responsible for millions of deaths in humans every year. Moreover, a rapid increase in resistance to existing drugs has posed an urgent ...read more
Citations
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2D-quantitative structure-activity relationships model using PLS method for anti-malarial activities of anti-haemozoin compounds.
Phuong Thuy Viet Nguyen,Truong Van Dat,Shusaku Mizukami,Duy Le Hoang Nguyen,Farhana Mosaddeque,Son Ngoc Kim,Duy Hoang Bao Nguyen,Oanh Thi Đinh,Tu Linh Vo,Giang Le Tra Nguyen,Cuong Quoc Duong,Satoshi Mizuta,Dao Ngoc Hien Tam,M. Phuong Truong,Nguyen Tien Huy,Kenji Hirayama +15 more
TL;DR: In this article, the authors developed two-dimensional-quantitative structure-activity relationships (QSAR) models of a series of 21 haemozoin inhibitors to explore the useful physicochemical parameters of the active compounds for estimation of anti-malarial activities.
Journal ArticleDOI
Sustainable synthesis of benzopyranderivativescatalyzed by MgO nanoparticles: Spectral, DFT and TEM analysis
Journal ArticleDOI
Naturally Occurring 8ß,13ß-kaur-15-en-17-al and Anti-Malarial Activity from Podocarpus polystachyus Leaves
M. S. Amir Rawa,Mohammad G Al-Thiabat,Toshihiko Nogawa,Yushi Futamura,Akiko Okano,Habibah A. Wahab +5 more
TL;DR: In this article , the anti-malarial evaluation of Podocarpus polystachyus phytoconstituents was investigated for the first time, and a new natural product, 8ß,13ß-kaur-15-en-17-al (1), along with three known compounds, including α-tocopherol hydroquinone (4), were isolated via HR-ESI-MS and NMR analyses.
Journal ArticleDOI
Identification of starvation-mimetic bioactive phytocomponent from Withania somnifera using in-silico molecular modelling and flow cytometry-based analysis for the management of malaria.
Deepak Pradhan,Prativa Biswasroy,Sharvari Kulkarni,Dilip Kumar Pradhan,Rajesh Bhola,Goutam Ghosh,Goutam Rath +6 more
TL;DR: In this article , a C28 steroidal lactone Withaferin A (WS-3) isolated from Withania somnifera leave extract shows better thermodynamically stable interactions with the glucose transporters (GLUT-1 and PfHT) to standard drugs metformin and lopinavir.
References
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Journal ArticleDOI
Serum factors governing intraerythrocytic development and cell cycle progression of Plasmodium falciparum.
Toshihide Mitamura,Kentaro Hanada,Elizabeth P. Ko-Mitamura,Masahiro Nishijima,Toshihiro Horii +4 more
TL;DR: This study can be a basis to explore the molecular mechanism of lipid traffic within the parasitized red blood cell (RBC), which can be an important adjunct to the development of drugs for malaria therapy.
Journal ArticleDOI
Differential effects of 4-aminoquinoline-containing antimalarial drugs on hemoglobin digestion in Plasmodium falciparum-infected erythrocytes.
Oleg Famin,Hagai Ginsburg +1 more
TL;DR: It is suggested that whereas chloroquine and amodiaquine inhibit the digestion of hemoglobin, mefloquine, quinine and possibly quinines inhibit the ingestion of host cell hemoglobin by interfering with the ingestion process.
Journal ArticleDOI
Partial purification and characterization of lactate dehydrogenase from Plasmodium falciparum.
TL;DR: Lactate dehydrogenase (LDH) from Plasmodium falciparum was partially purified by two different procedures, demonstrating the usefulness of this procedure for the partial purification of small quantities of parasite protein.
Journal ArticleDOI
Antimalarial natural products: a review
TL;DR: This article tries to briefly indicate that some plants which previously were used to treat malaria, as a result of deficiencies of synthetic drugs, have revived into useful products once more.
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