Histamine in diabetes: Is it time to reconsider?
Alessandro Pini,Ilona Obara,Emma Battell,Paul L. Chazot,Arianna Carolina Rosa,Arianna Carolina Rosa +5 more
TLDR
An interesting upsurge in the field which provides scope for new insights into the role of histamine in diabetes is revealed.About:
This article is published in Pharmacological Research.The article was published on 2016-09-01 and is currently open access. It has received 21 citations till now. The article focuses on the topics: Histamine receptor & Histamine.read more
Citations
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Histamine, histamine receptors, and neuropathic pain relief.
TL;DR: This review summarizes the most recent findings on the role of histamine and the effects mediated by the four histamine receptors in response to the various stimuli associated with and promoting neuropathic pain and particularly focuses on mechanisms underlying histamine‐mediated analgesia.
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Current Knowledge and Perspectives on Histamine H1 and H2 Receptor Pharmacology: Functional Selectivity, Receptor Crosstalk, and Repositioning of Classic Histaminergic Ligands
TL;DR: Novel aspects of the pharmacology and molecular mechanisms of histamine receptors that should be contemplated for optimizing current therapies, repositioning histaminergic ligands for new therapeutic uses, or even including agonists of the histamine system in the treatment of different pathologies such as leukemia or neurodegenerative disorders are discussed.
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Reduction of hyaluronan and increased expression of HYBID (alias CEMIP and KIAA1199) correlate with clinical symptoms in photoaged skin.
Hiroyuki Yoshida,Aya Nagaoka,Aya Komiya,Mika Aoki,S. Nakamura,T. Morikawa,R. Ohtsuki,Tetsuya Sayo,Yasunori Okada,Yoshito Takahashi +9 more
TL;DR: It is shown that photoageing‐dependent changes in HA and their molecular mechanisms, and the relationship between HA metabolism and clinical symptoms in photoaged skin remain elusive.
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Maternal Diabetes and Fetal Programming Toward Neurological Diseases: Beyond Neural Tube Defects
Berenice Márquez-Valadez,Rocío Valle-Bautista,Guadalupe García-López,Néstor F. Díaz,Anayansi Molina-Hernández +4 more
TL;DR: The state of the art on this topic is explored to help establish the way forward in the study of fetal programming under hyperglycemia and its impact on neurological and psychiatric disorders.
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Histamine H4 receptor antagonism prevents the progression of diabetic nephropathy in male DBA2/J mice
Alessandro Pini,Cristina Grange,Eleonora Veglia,Monica Argenziano,Roberta Cavalli,Daniele Guasti,Laura Calosi,Corrado Ghè,Roberto Solarino,Robin L. Thurmond,Giovanni Camussi,Paul L. Chazot,Arianna Carolina Rosa +12 more
TL;DR: The data suggest that the H4R participates in diabetic nephropathy progression through both a direct effect on tubular reabsorption and an indirect action on renal tissue architecture via inflammatory cell recruitment, and H 4R antagonism emerges as a possible new multi‐mechanism therapeutic approach to counteract development of diabetic neephropathy development.
References
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Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K. G. M. M. Alberti,Paul Zimmet +1 more
TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
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Diagnosis and Classification of Diabetes Mellitus
TL;DR: The chronic hyperglycemia of diabetes is associated with long-term damage, dys-function, and failure of differentorgans, especially the eyes, kidneys, nerves, heart, and blood vessels.
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Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments
Solomon Tesfaye,Andrew J.M. Boulton,Peter J. Dyck,Roy Freeman,Michael Horowitz,Péter Kempler,Giuseppe Lauria,Rayaz A. Malik,Vincenza Spallone,Aaron I. Vinik,Luciano Bernardi,Paul Valensi +11 more
TL;DR: A joint meeting of the 19th annual Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB) and the 8th International Symposium on Diabetes in Toronto, Canada, 13-18 October 2009, expert panels were convened to provide updates on classification, definitions, diagnostic criteria, and treatments of diabetic peripheral neuropathies as mentioned in this paper.
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Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor.
TL;DR: It is shown here that histamine inhibits its own release from depolarized slices of rat cerebral cortex, an action apparently mediated by a class of receptor (H3) pharmacologically distinct from those previously characterized, that is, the H1 and H2 receptors.