Journal ArticleDOI
Hodgkin's disease with lymphocytic predominance, nodular type (nodular paragranuloma) and progressively transformed germinal centres--a cytohistological study.
TLDR
It must be concluded that nodular paragranuloma takes place in B‐cell areas of the lymph node, unlike the other, or at least most of theother, types of Hodgkin's disease.Abstract:
The histology, cytology, and enzyme cytochemistry of a nodular variant of Hodgkin's disease with lymphocytic predominance, called 'nodular paragranuloma', are presented. The histological features of nodular paragranuloma are compared with those of progressively transformed germinal centres, which are enlarged follicles showing a predominance of small lymphocytes and some residual germinal centre cells. Progressively transformed germinal centres are sometimes found in nonspecific lymphadenitis (reactive hyperplasia). The histological similarity and the association between lymph nodes with nodular paragranuloma and lymph nodes with progressively transformed germinal centres in the same patient at different moments or at the same time, suggest that progressively transformed germinal centres are the origin of nodular paragranuloma. Hence, it must be concluded that nodular paragranuloma takes place in B-cell areas of the lymph node, unlike the other, or at least most of the other, types of Hodgkin's disease.read more
Citations
More filters
Journal ArticleDOI
Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cells
Ulrich Schwab,Harald Stein,J. Gerdes,Hilmar Lemke,Hartmut Kirchner,Michael Schaadt,Volker Diehl +6 more
TL;DR: Production of mouse monoclonal antibodies against the Hodgkin cell line L428 was described and one hybridoma antibody was found to be specific for H and SR cells of all Hodgkin's lymphomas tested and a minute, but distinct new cell population in normal tonsils and lymph nodes.
Journal ArticleDOI
Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population
Harald Stein,Johannes Gerdes,Ulrich Schwab,Hilmar Lemke,David Y. Mason,Andreas Ziegler,Wolfgang Schienle,Volker Diehl +7 more
TL;DR: It is suggested that the hitherto unknown cell population detected with the monoclonal antibody Ki‐I in normal lymphoid tissue is the normal equivalent of H and SR cells.
Journal ArticleDOI
European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes
Ioannis Anagnostopoulos,Martin-Leo Hansmann,Kaarle Franssila,Martin Harris,Nancy L. Harris,Elaine S. Jaffe,J. Han,J. M. van Krieken,Sibrand Poppema,Teresa Marafioti,Jeremy Franklin,M Sextro,Volker Diehl,Harald Stein +13 more
TL;DR: Clinically, patients with LPHD and NLRCHD showed similar disease characteristics at presentation but differed in the frequency of multiple relapses and prognosis after relapse, and how frequent T-cell-rich large B-cell lymphoma (TCRLBCL) is among LPHD, and found differential diagnostic criteria distinguishing between the 2 lymphoma categories.
Journal ArticleDOI
Hodgkin's lymphoma: the pathologist's viewpoint
S. A. Pileri,Stefano Ascani,Lorenzo Leoncini,Elena Sabattini,Pier Luigi Zinzani,Pier Paolo Piccaluga,Alessandro Pileri,M. Giunti,Brunangelo Falini,Giovanni B. Bolis,Harald Stein +10 more
TL;DR: Treatments adjusted to the pathobiological characteristics of the tumour in at risk patients have been proposed and are on the way to being applied.
Journal ArticleDOI
Hodgkin's disease, lymphocytic predominance nodular. Increased risk for subsequent non-Hodgkin's lymphomas.
TL;DR: It is concluded that HDLPN is a clinicopathological entity with a good prognosis, but that it may sometimes change into a more malignant lymphoma of the Hodgkin's or non‐Hodgkin's type.
References
More filters
Journal Article
Report of the Nomenclature Committee
Journal Article
The Pathology and Nomenclature of Hodgkin's Disease
Robert J. Lukes,James J. Butler +1 more
TL;DR: The demonstrated relationship between these histologic types, and the clinical stages and survival, provides further support for the importance of host factors and also presents an effective basis for prognostication.
Journal ArticleDOI
Follicular lymphoma; a re-evaluation of its position in the scheme of malignant lymphoma, based on a survey of 253 cases.
Book ChapterDOI
The Cytologic, Histologic, and Functional Bases for a Modern Classification of Lymphomas
TL;DR: It has become evident that lymphocytes and plasma cells are not derived from reticulum cells, and it has been shown that most macrophages and one of their specific functional forms, namely, epithelioid cells, are of monocytic origin.