Book ChapterDOI
Hormesis: A potential strategic approach to the treatment of neurodegenerative disease.
Edward J. Calabrese,Mark P. Mattson,Gaurav Dhawan,Rachna Kapoor,Vittorio Calabrese,James Giordano +5 more
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TLDR
This review describes neuroprotective effects mediated by pre- and post-conditioning-induced processes that act via the quantitative features of the hormetic dose response that lead to the development of acquired resilience that can protect neuronal systems from endogenous and exogenous stresses and insult.Abstract:
This review describes neuroprotective effects mediated by pre- and post-conditioning-induced processes that act via the quantitative features of the hormetic dose response. These lead to the development of acquired resilience that can protect neuronal systems from endogenous and exogenous stresses and insult. Particular attention is directed to issues of dose optimization, inter-individual variation, and potential ways to further study and employ hormetic-based preconditioning approaches in medical and public health efforts to treat and prevent neurodegenerative disease.read more
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Journal ArticleDOI
Baicalin-Induced Autophagy Preserved LPS-Stimulated Intestinal Cells from Inflammation and Alterations of Paracellular Permeability.
Valentina Rizzo,Nadia Ferlazzo,Monica Currò,Gaetano Isola,Marco Matarese,Maria Paola Bertuccio,Daniela Caccamo,Giovanni Matarese,Riccardo Ientile +8 more
TL;DR: In this paper, Baicalin (BA) extracts from the root of Scutellaria baicalensis were extracted from HT-29 cells and they were exposed to lipopolysaccharide (LPS), in presence or absence of BA, for 4 hours.
Journal ArticleDOI
Demonstrated hormetic mechanisms putatively subserve riluzole-induced effects in neuroprotection against amyotrophic lateral sclerosis (ALS): Implications for research and clinical practice
TL;DR: This paper showed that riluzole, an FDA-approved treatment for amyotrophic lateral sclerosis (ALS), displays and exerts hormetic biphasic dose responses, which have important implications for the experimental study and clinical treatment of ALS.
Journal ArticleDOI
Gene bookmarking by the heat shock transcription factor programs the insulin-like signaling pathway.
TL;DR: In this article, the effects of activating the universal stress-responsive heat shock transcription factor HSF-1 in the germline of Caenorhabditis elegans were examined.
Journal ArticleDOI
PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease
TL;DR: In this paper , the effects and potential mechanisms of curcumin-loaded PLGA nanoparticles in Alzheimer's disease were discussed and a review article discusses the effects, potential mechanisms, and effects and effects of the nanoparticles.
Journal ArticleDOI
PDK4 decrease neuronal apoptosis via inhibiting ROS-ASK1/p38 pathway in early brain injury after subarachnoid hemorrhage.
Xuan Gao,Sung-Man Bae,Yong-Yue Gao,Huiying Yan,Guang-Jie Liu,Yan Zhou,Tao Tao,Ting-Ting Yue,Cong Pang,Xiang-Xin Chen,Sen Gao,Ling-Yun Wu,Chun-Hua Hang,Wei Li +13 more
TL;DR: In this article, metabolic disorders may play key roles in oxidative stress and neuronal apoptosis in response to early brain injury (EBI) after subarachnoid hemorrhage (SAH).
References
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Journal ArticleDOI
An integrative theory of prefrontal cortex function
Earl K. Miller,Jonathan D. Cohen +1 more
TL;DR: It is proposed that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them, which provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task.
Journal ArticleDOI
Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.
TL;DR: The multiple anginal episodes that often precede myocardial infarction in man may delay cell death after coronary occlusion, and thereby allow for greater salvage of myocardium through reperfusion therapy, which is proposed to protect the heart from a subsequent sustained ischemic insult.
Journal ArticleDOI
Inverted-U-shaped dopamine actions on human working memory and cognitive control.
Roshan Cools,Mark D'Esposito +1 more
TL;DR: Evidence from a series of studies with experimental animals, healthy humans, and patients with Parkinson's disease suggests the existence of an optimum DA level for cognitive function implicates the need to take into account baseline levels of DA when isolating the effects of DA.
Journal ArticleDOI
Adaptive Response of Human Lymphocytes to Low Concentrations of Radioactive Thymidine
TL;DR: When human lymphocytes were cultured with [3H]thymidine, which acts as a source of low-level chronic radiation, and then exposed to 150 rad of x-rays at 5, 7, 9, or 11 hours before fixation, the yield of chromatid aberrations was less than the sum of the yields of aberration induced by [3 H]thcyidine and x-ray separately.
Journal ArticleDOI
Vascular Endothelial Growth Factor Has Neurotrophic Activity and Stimulates Axonal Outgrowth, Enhancing Cell Survival and Schwann Cell Proliferation in the Peripheral Nervous System
TL;DR: It is reported that VEGF165 has neurotrophic actions on cultured adult mouse superior cervical ganglia and dorsal root ganglia, measured as axonal outgrowth, and it is concluded that V EGF has both neurotrophic and mitogenic activity on cells in the peripheral nervous system.
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