Host-Guest Chemistry in Supramolecular Theranostics.
Guocan Yu,Xiaoyuan Chen +1 more
TLDR
This review summarizes the progress of supramolecular theranostics on the basis of host-guest chemistry benefiting from their fantastic topological structures and outstanding supramolescular chemistry to provide new methodologies to overcome the obstacles faced by the traditional theranostic systems.Abstract:
Macrocyclic hosts, such as cyclodextrins, calixarenes, cucurbiturils, and pillararenes, exhibit unparalleled advantages in disease diagnosis and therapy over the past years by fully taking advantage of their host-guest molecular recognitions. The dynamic nature of the non-covalent interactions and selective host-guest complexation endow the resultant nanomaterials with intriguing properties, holding promising potentials in theranostic fields. Interestingly, the differences in microenvironment between the abnormal and normal cells/tissues can be employed as the stimuli to modulate the host-guest interactions, realizing the purpose of precise diagnosis and specific delivery of drugs to lesion sites. In this review, we summarize the progress of supramolecular theranostics on the basis of host-guest chemistry benefiting from their fantastic topological structures and outstanding supramolecular chemistry. These state-of-the-art examples provide new methodologies to overcome the obstacles faced by the traditional theranostic systems, promoting their clinical translations.read more
Citations
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Journal ArticleDOI
Supramolecular cancer nanotheranostics
TL;DR: In this paper, the authors summarized the progress of supramolecular cancer nanotheranostics and provided guidance for designing new targeted theranostic agents based on extensive state-of-the-art research.
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A Nanomedicine Fabricated from Gold Nanoparticles‐Decorated Metal–Organic Framework for Cascade Chemo/Chemodynamic Cancer Therapy
Yuan Ding,Hao Xu,Chang Xu,Zongrui Tong,Sitong Zhang,Yang Bai,Yining Chen,Qianhui Xu,Liuzhi Zhou,Hao Ding,Zhongquan Sun,Sheng Yan,Zhengwei Mao,Weilin Wang +13 more
TL;DR: In vivo results demonstrate that the combination of chemotherapy and chemodynamic therapy effectively suppresses the tumor growth, meantime the systemic toxicity of this nanomedicine is greatly avoided.
Journal ArticleDOI
Biomedical Applications of Calixarenes: State of the Art and Perspectives.
TL;DR: The diverse biomedical applications of CAs, representing the third generation of supramolecular hosts and one of the most widely studied macrocyclic scaffolds, are summarized including in-vitro diagnosis, in- vivo diagnosis (bioimaging), and therapy.
Journal ArticleDOI
Supramolecular prodrugs based on host–guest interactions
TL;DR: This summary is designed to highlight the many advantages of supramolecular prodrugs, including ease-of-preparation, molecular-level protection, sensitive response to bio-stimuli, traceless release, and adaptability to different drugs.
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