Journal ArticleDOI
Hot-melt granulation in a twin screw extruder: effects of processing on formulations with caffeine and Ibuprofen.
TLDR
The low melting point of ibuprofen had a dominant influence by producing larger, stronger granules, whereas the caffeine products were more comparable to a blank containing no active ingredient.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 2013-12-01. It has received 30 citations till now. The article focuses on the topics: Granulation.read more
Citations
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Journal ArticleDOI
Polymeric formulations for drug release prepared by hot melt extrusion: application and characterization.
TL;DR: In this review, the basic principles of the HME process are described together with an overview of some of the most common biodegradable and nonbiodesgradable polymers used for the preparation of different formulations using this method.
Journal ArticleDOI
Twin screw granulation – review of current progress
TL;DR: A review of the current literature for wet granulation processes studied in twin screw extrusion machinery concludes that some major challenges still lay ahead related to scalability, variations in the processing regimes related to degree of channel fill and the impact of wetting and granulation of complex powder formulations.
Journal ArticleDOI
Recent progress in continuous and semi-continuous processing of solid oral dosage forms: a review
TL;DR: The attempt to connect the primary and secondary production steps proves that development of continuously operating lines is possible and a mind-set change is needed to be able to face, and fully assess, the advantages and disadvantages of switching from batch to continuous mode production.
Journal ArticleDOI
Continuous twin screw melt granulation of glyceryl behenate: Development of controlled release tramadol hydrochloride tablets for improved safety.
Justin M. Keen,Justin M. Keen,Connor J. Foley,Justin R. Hughey,Ryan C. Bennett,Vincent Jannin,Yvonne Rosiaux,Delphine Marchaud,James W. McGinity +8 more
TL;DR: A continuous granulation process for direct production of granules using this technique with glyceryl behenate as a binder is developed and controlled release tablets containing tramadol HCl are determined to be resistant to alcohol induced dose dumping.
Journal ArticleDOI
Hot-melt extrusion: Highlighting recent advances in pharmaceutical applications
TL;DR: This review channels to a holistic perspective of several equipment components, processing requirements, materials used in HME, and various drug delivery systems utilizing HME in recent years and gives a comprehensive treatise on several novel opportunities and innovations.
References
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Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TL;DR: The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.
Journal ArticleDOI
Fundamental studies of granule consolidation Part 1: Effects of binder content and binder viscosity
TL;DR: Granule consolidation during tumbling was found to be a complex process controlled by the balance between the different mechanisms that resist granule deformation: interparticle friction and viscous dissipation as discussed by the authors.
Journal ArticleDOI
Agglomerate strength measurement using a uniaxial confined compression test
TL;DR: In this paper, a simple first-order lumped-parameter analysis of this compression process is presented, treating the system as purely dissipative and applying the Mohr-Coulomb macroscopic failure criterion.
Journal ArticleDOI
Effects of grinding and compression on crystal structure of anhydrous caffeine
TL;DR: In this paper, the extent of the polymorphic transformation of anhydrous caffeine has been studied as a function of grinding time and compression pressure by using quantitative X-ray diffraction analysis.
Journal ArticleDOI
Application of melt granulation technology to enhance tabletting properties of poorly compactible high-dose drugs
Jay Parthiban Lakshman,James Kowalski,Madhav Vasanthavada,Wei-Qin Tong,Yatindra Joshi,Abu T.M. Serajuddin +5 more
TL;DR: A melt granulation (MG) process that employs a twin-screw extruder has been developed to enhance compactibility of poorly compactible high-dose drug substances.
Related Papers (5)
Examining the mechanics of granulation with a hot melt binder in a twin-screw extruder
B. Mu,Michael Thompson +1 more