Journal ArticleDOI
How is our self related to midline regions and the default-mode network?
Pengmin Qin,Georg Northoff +1 more
TLDR
The data suggest that the sense of self may result from a specific kind of interaction between resting state activity and stimulus-induced activity, i.e., rest-stimulus interaction, within the midline regions.Citations
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Altered Brain Long-Range Functional Interactions Underlying the Link Between Aberrant Self-experience and Self-other Relationship in First-Episode Schizophrenia
Sjoerd J. H. Ebisch,Dante Mantini,Dante Mantini,Georg Northoff,Anatolia Salone,Domenico De Berardis,Federico Ferri,Filippo Maria Ferro,Massimo Di Giannantonio,Gian Luca Romani,Vittorio Gallese +10 more
TL;DR: This fMRI study provides new evidence for a cortical link between aberrant self-experience and social cognition in first-episode schizophrenia (FES), and suggests an imbalance in the processing between internally and externally guided information and its abnormal integration with self-referential processing as mediated by PCC.
Journal ArticleDOI
Neural Correlates of Affective Disturbances: A Comparative Meta-analysis of Negative Affect Processing in Borderline Personality Disorder, Major Depressive Disorder, and Posttraumatic Stress Disorder.
TL;DR: The present results support shared and disorder-specific neural abnormalities in patients with affective disturbances, including limbic hyperactivations in BPD and PTSD compared with limbic activation of HCs.
Journal ArticleDOI
Resting state glutamate predicts elevated pre-stimulus alpha during self-relatedness: A combined EEG-MRS study on "rest-self overlap".
Yu Bai,Takashi Nakao,Jiameng Xu,Pengmin Qin,Pedro Chaves,Alexander Heinzel,Niall W. Duncan,Timothy Joseph Lane,Nai Shing Yen,Shang-Yueh Tsai,Georg Northoff +10 more
TL;DR: Results show pre-stimulus alpha power and resting state glutamate concentration to mediate rest-self overlap to dispose or incline subjects to assign high degrees of self-relatedness to perceptual stimuli.
Journal ArticleDOI
Classifying heterogeneous presentations of PTSD via the default mode, central executive, and salience networks with machine learning
Andrew A. Nicholson,Andrew A. Nicholson,Sherain Harricharan,Maria Densmore,Richard W. J. Neufeld,Tomas Ros,Margaret C. McKinnon,Paul A. Frewen,Jean Théberge,Rakesh Jetly,David Pedlar,Ruth A. Lanius +11 more
TL;DR: A comparison of ICNs between PTSD, dissociative subtype PTSD, and healthy controls revealed unique group connectivity to brain areas associated with PTSD symptoms.
Journal ArticleDOI
Reduced orbitofrontal cortical volume is associated with interdependent self-construal
TL;DR: Analysis found that the highest level of interdependent self-construal is achieved when those who are relatively low in the OFC volume are simultaneously high in object imagery, consistent with previous evidence that interdependence, as realized via obligation and duty, requires both the reduced self-interest and vigilant cognitive attunement to environmental context.
References
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Journal ArticleDOI
A default mode of brain function.
Marcus E. Raichle,Ann Mary MacLeod,Abraham Z. Snyder,William J. Powers,Debra A. Gusnard,Gordon L. Shulman +5 more
TL;DR: A baseline state of the normal adult human brain in terms of the brain oxygen extraction fraction or OEF is identified, suggesting the existence of an organized, baseline default mode of brain function that is suspended during specific goal-directed behaviors.
Journal ArticleDOI
AFNI: software for analysis and visualization of functional magnetic resonance neuroimages
TL;DR: A package of computer programs for analysis and visualization of three-dimensional human brain functional magnetic resonance imaging (FMRI) results is described and techniques for automatically generating transformed functional data sets from manually labeled anatomical data sets are described.
Journal ArticleDOI
The Brain's Default Network Anatomy, Function, and Relevance to Disease
TL;DR: Past observations are synthesized to provide strong evidence that the default network is a specific, anatomically defined brain system preferentially active when individuals are not focused on the external environment, and for understanding mental disorders including autism, schizophrenia, and Alzheimer's disease.
Journal ArticleDOI
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Michael D. Fox,Abraham Z. Snyder,Justin L. Vincent,Maurizio Corbetta,David C. Van Essen,Marcus E. Raichle +5 more
TL;DR: It is suggested that both task-driven neuronal responses and behavior are reflections of this dynamic, ongoing, functional organization of the brain, featuring the presence of anticorrelated networks in the absence of overt task performance.
Journal ArticleDOI
Functional connectivity in the resting brain: A network analysis of the default mode hypothesis
TL;DR: This study constitutes, to the knowledge, the first resting-state connectivity analysis of the default mode and provides the most compelling evidence to date for the existence of a cohesive default mode network.