Human to Mosquito Transmission of Dengue Viruses
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TLDR
Examination of features of the human infection required for the mosquito to acquire the virus via natural blood feeding, as well as the biological and environmental factors that influence a mosquito’s susceptibility to infection, up to the point that they are capable of transmitting the virus to a new host.Abstract:
The successful transmission of dengue virus from a human host to a mosquito vector requires a complex set of factors to align. It is becoming increasingly important to improve our understanding of the parameters that shape the human to mosquito component of the transmission cycle so that vaccines and therapeutic anti-virals can be fully evaluated and epidemiological models refined. Here we describe these factors, and discuss the biological and environmental impacts and demographic changes that are influencing these dynamics. Specifically, we examine features of the human infection required for the mosquito to acquire the virus via natural blood feeding, as well as the biological and environmental factors that influence a mosquito’s susceptibility to infection, up to the point that they are capable of transmitting the virus to a new host.read more
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Journal ArticleDOI
The global distribution of the arbovirus vectors Aedes aegypti and Ae. Albopictus
Moritz U. G. Kraemer,Marianne E. Sinka,Kirsten A. Duda,Adrian Mylne,Freya M Shearer,Christopher M. Barker,Chester G. Moore,Roberta G. Carvalho,Giovanini E. Coelho,Wim Van Bortel,Guy Hendrickx,Francis Schaffner,Iqbal R. F. Elyazar,Hwa-Jen Teng,Oliver J. Brady,Jane P. Messina,David M. Pigott,Thomas W. Scott,David L. Smith,G. R. William Wint,Nick Golding,Simon I. Hay +21 more
TL;DR: In this paper, the authors compile the largest contemporary database for both species and pair it with relevant environmental variables predicting their global distribution, showing Aedes distributions to be the widest ever recorded; now extensive in all continents, including North America and Europe.
Journal Article
The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus
TL;DR: This work compile the largest contemporary database for both species and pair it with relevant environmental variables predicting their global distribution, showing Aedes distributions to be the widest ever recorded; now extensive in all continents, including North America and Europe.
Journal ArticleDOI
Asymptomatic humans transmit dengue virus to mosquitoes
Veasna Duong,Louis Lambrechts,Richard Paul,Sowath Ly,Rath Srey Lay,Kanya C. Long,Rekol Huy,Arnaud Tarantola,Thomas W. Scott,Thomas W. Scott,Anavaj Sakuntabhai,Philippe Buchy +11 more
TL;DR: It is shown that, despite their lower average level of viremia, asymptomatic people can be infectious to mosquitoes, and have the potential to contribute significantly more to virus transmission to mosquitoes than previously recognized.
Journal ArticleDOI
Mapping the global potential distributions of two arboviral vectors Aedes aegypti and Ae. albopictus under changing climate
TL;DR: The current potential distributions of both vectors are updated and details are provided to better guide surveillance and control programs of Ae.
Journal ArticleDOI
Comparative Analysis of Dengue and Zika Outbreaks Reveals Differences by Setting and Virus.
Sebastian Funk,Adam J. Kucharski,Anton Camacho,Rosalind M Eggo,Laith Yakob,Lawrence M. Murray,W. John Edmunds +6 more
TL;DR: Compared three outbreaks of dengue and Zika virus in two different island settings in Micronesia, using a mathematical model of transmission dynamics and making full use of commonalities in disease and setting between the outbreaks, it is found that the estimated reproduction numbers for Zika and d Dengue were similar when considered in the same setting, but that, conversely, reproduction number for the same disease can vary considerably by setting.
References
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The global distribution and burden of dengue
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TL;DR: The successful transinfection of A. aegypti with the avirulent wMel strain of Wolbachia, which induces the reproductive phenotype cytoplasmic incompatibility with minimal apparent fitness costs and high maternal transmission, providing optimal phenotypic effects for invasion is described.
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Spread of the tiger: global risk of invasion by the mosquito Aedes albopictus.
TL;DR: A genetic algorithm is used, Genetic Algorithm for Rule Set Production (GARP), to determine the ecological niche of Ae.
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