Journal ArticleDOI
Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants.
Marucia Chacur,I. Longo,Gisele Picolo,José María Gutiérrez,Bruno Lomonte,José Luiz Guerra,Catarina Teixeira,Yara Cury +7 more
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TLDR
The results suggest that Asp49 and Lys49 PLA(2)s are important hyperalgesic components of B. asper venom, and that Lys49 and Asp 49 PLA( 2)s exert their algogenic actions through different molecular mechanisms.About:
This article is published in Toxicon.The article was published on 2003-05-01. It has received 91 citations till now. The article focuses on the topics: Hyperalgesia.read more
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Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity
TL;DR: A model is presented to explain the difference between PLA2s that induce predominantly local myonecrosis and those inducing both local and systemic myotoxicity, and the former bind not only to muscle cells, but also to other cell types, thereby precluding a systemic distribution of thesePLA2s.
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An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action.
TL;DR: It is proposed that all the toxic activities of Lys49 PLA2s are related to their ability to destabilize natural and artificial membranes, using a cationic/hydrophobic effector site located at their C-terminal loop.
Journal ArticleDOI
Inflammatory effects of snake venom myotoxic phospholipases A2.
TL;DR: This work reviews the proinflammatory and nociceptive effects evoked by myotoxic PLA2s and their mechanisms of action and concludes that these proteins promote inflammation and pain by mechanisms not related to phospholipid hydrolysis nor to mobilization of arachidonic acid.
Journal ArticleDOI
Experimental pathology of local tissue damage induced by Bothrops asper snake venom
TL;DR: The search for novel toxin inhibitors represents a potential avenue for improving the treatment of this serious aspect of snakebite envenomation, as muscle tissue regeneration after venom-induced pathological effects is often impaired, thus resulting in permanent tissue loss and dysfunction.
Journal ArticleDOI
Inflammation induced by Bothrops asper venom
TL;DR: The current status of the understanding of the inflammatory reaction, including pain, triggered by Bothrops asper venom is described and studies dealing with the mechanisms of inflammatory and nociceptive properties of phospholipases A(2), a metalloproteinase and serine-proteases isolated from both humans and experimental animals are described.
References
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Ethical guidelines for investigations of experimental pain in conscious animals.
TL;DR: The Committee for Research and Ethical Issues of the International Association for the Study of Pain (IASP®) is concerned with the ethical aspects of studies producing experimental pain and any suffering it may cause in animals.
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Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
T. D. Penning,John J. Talley,Bertenshaw,Jeffery S. Carter,P. W. Collins,Stephen H. Docter,Matthew J. Graneto,Len F. Lee,James W. Malecha,Julie M. Miyashiro,Roland S. Rogers,D. J. Rogier,Stella S. Yu,AndersonGD,E. G. Burton,J. N. Cogburn,Susan A. Gregory,Carol M. Koboldt,W E Perkins,Karen Seibert,A. W. Veenhuizen,Yan Y. Zhang,P. C. Isakson +22 more
TL;DR: 1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis, is identified.
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Diversity of group types, regulation, and function of phospholipase A2.
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The expanding superfamily of phospholipase A(2) enzymes: classification and characterization.
David A. Six,Edward A. Dennis +1 more
TL;DR: This review updates the classification of the various PLA(2)'s now described in the literature, and expands or realignment of Groups VI, VII and VIII, as well as the addition of Group XIPLA(2) from plants.
Journal ArticleDOI
Peripheral and central mechanisms of cutaneous hyperalgesia.
TL;DR: In the literature, there are some contradictions with respect to the stimulus modalities to which hyperalgesia and sensitization occur and this contradiction should spawn further investigations into the mechanical response properties of nociceptors and into the molecular mechanisms of heat sensitization.