Hypoxia inducible lncRNA-CBSLR modulates ferroptosis through m6A-YTHDF2-dependent modulation of CBS in gastric cancer
Hui Yang,Yiren Hu,Yiren Hu,Mingzhe Weng,Mingzhe Weng,Xiaocen Liu,Ping Wan,Ping Wan,Ye Hu,Mingzhe Ma,Mingzhe Ma,Yan Zhang,Hongping Xia,Kun Lv +13 more
TLDR
In this article, the authors identify hypoxia inducible lncRNAs and their biological function in gastric cancer (GC) and reveal a novel mechanism in how HIF1α/CBSLR modulates ferroptosis/chemoresistance in GC.About:
This article is published in Journal of Advanced Research.The article was published on 2021-10-05 and is currently open access. It has received 0 citations till now. The article focuses on the topics: Protein polyubiquitination.read more
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Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
Hyuna Sung,Jacques Ferlay,Rebecca L. Siegel,Mathieu Laversanne,Isabelle Soerjomataram,Ahmedin Jemal,Freddie Bray +6 more
TL;DR: The GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer (IARC) as mentioned in this paper show that female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung cancer, colorectal (11 4.4%), liver (8.3%), stomach (7.7%) and female breast (6.9%), and cervical cancer (5.6%) cancers.
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Cancer statistics in China, 2015
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TL;DR: Many of the estimated cancer cases and deaths can be prevented through reducing the prevalence of risk factors, while increasing the effectiveness of clinical care delivery, particularly for those living in rural areas and in disadvantaged populations.
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TL;DR: Pharmacological targeting of ACSL4 with thiazolidinediones, a class of antidiabetic compound, ameliorated tissue demise in a mouse model of ferroptosis, suggesting that ACSL 4 inhibition is a viable therapeutic approach to preventing ferroPTosis-related diseases.
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