Book ChapterDOI
Imaging tumor microenvironment with ultrasound
Mallika Sridhar,Michael F. Insana +1 more
- Vol. 19, pp 516-528
TLDR
In this article, the authors used ultrasound to image viscoelastic features of tumors, which describe microenvironmental factors that stimulate signaling pathways in tumors that ultimately affect metastatic potential and response to traditional therapeutics.Abstract:
Recent advances in molecular biology are providing new opportunities for breast cancer imaging. Our approach uses ultrasound to image viscoelastic features of tumors. These features describe microenvironmental factors that stimulate signaling pathways in tumors that ultimately affect metastatic potential and response to traditional therapeutics. This paper explains the motivation for the approach, describes measurements in phantoms and patients, and defines measurement sensitivity using hydrogels with tissue-like features.read more
Citations
More filters
Journal ArticleDOI
Viscoelasticity imaging using ultrasound: parameters and error analysis.
TL;DR: The focus of this paper is on imaging parameter estimation from ultrasonic echo data, and how jitter from hand-held force applicators used for clinical applications propagate through the imaging chain to generate image noise.
Journal ArticleDOI
A Robust Method to Estimate the Time Constant of Elastographic Parameters
TL;DR: Variable projection (VP) is proposed, a new technique named variable projection to estimate accurately and robustly the TC and steady-state value of the elastographic parameter of interest from its temporal curve that is robust to noise and capable of estimating the time constant with accuracy higher than that of typically employed curve-fitting techniques.
Posted Content
A spline interpolation based data reconstruction technique for estimation of strain time constant in ultrasound poroelastography
TL;DR: A cubic spline–based interpolation method, which allows to use only good quality strain frames (i.e., frames with sufficiently high signal-to-noise ratio [SNR]) to estimate the strain TC, and is of great help in applications relying on the accurate assessment of the temporal behavior of strain data.
Journal ArticleDOI
A Spline Interpolation–based Data Reconstruction Technique for Estimation of Strain Time Constant in Ultrasound Poroelastography:
TL;DR: In this article, a cost-effective and non-invasive imaging technique, which can be used to reconstruct mechanical parameters of tissues such as Young's modulus, Poisson's ratio, inters...
Proceedings ArticleDOI
4J-1 Towards a Molecular Level Understanding of Elasticity in Tissues and Hydrogels
TL;DR: In this article, the authors used low order discrete rheological models from linear viscoelastic theory to reduce data dimensionality yielding parameters related to stiffness and viscosity: elastic strain and two retardation time constants.
References
More filters
Journal ArticleDOI
Ultrasonic analysis of peptide- And antibody-targeted microbubble contrast agents for molecular imaging of α vβ 3-expressing cells
Paul A. Dayton,David Pearson,Jarrod Clark,Scott I. Simon,Patricia A. Schumann,Reena Zutshi,Terry O. Matsunaga,Katherine W. Ferrara +7 more
TL;DR: Results suggest that adherent targeted Contrast agents are differentiable from free-floating microbubbles, that targeted contrast agents provide higher sensitivity in the detection of angiogenesis, and that conventional ultrasound imaging techniques such as signal subtraction or decorrelation detection can be used to detect integrin-expressing vasculature with sufficient signal-to-noise.
Journal ArticleDOI
Tissue-mimicking oil-in-gelatin dispersions for use in heterogeneous elastography phantoms.
Ernest L. Madsen,Gary R. Frank,Thomas A. Krouskop,Thomas A. Krouskop,Tomy Varghese,Faouzi Kallel,Jonathan Ophir +6 more
TL;DR: Elastographic data for heterogeneous phantoms, in which the only variable is safflower oil concentration, demonstrate stability of inclusion geometry and elastic strain contrast and Young's modulus ratios (elastic contrasts) producible in a heterogeneous phantom are as high as 2.7.
Book ChapterDOI
Chapter 27 Three-dimensional imaging of extracellular matrix and extracellular matrix-cell interactions
TL;DR: Noninvasive and nondestructive imaging modalities such as reflection and autofluorescence can readily be used in conjunction with the 3-D optical sectioning capabilities of confocal and multiphoton microscopy to investigate biological processes within living systems.
Journal ArticleDOI
In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia.
Craig K. Abbey,Alexander D. Borowsky,Erik T. McGoldrick,Jeffrey P. Gregg,Jeannie E. Maglione,Robert D. Cardiff,Simon R. Cherry +6 more
TL;DR: P positron emission tomography imaging of 2-[18F]-fluoro-deoxy-D-glucose mice is utilized to monitor longitudinal development of mammary intraepithelial neoplasia outgrowths in immunocompetent FVB/NJ mice, promising more effective analysis of tumor progression and reduction of the number of animals needed for statistical power in preclinical therapeutic intervention trials.
Journal ArticleDOI
Effect of applied uniaxial stress on rate and mechanical effects of cross-linking in tissue-derived biomaterials
TL;DR: It is demonstrated that the rate of cross-linking in glutaraldehyde and epoxide homobifunctional reagents can be modulated by uniaxial stress (strain), and systematic effects on mechanical properties: decreasing extensibility and plastic strain while increasing tensile strength.