Book ChapterDOI
Imaging tumor microenvironment with ultrasound
Mallika Sridhar,Michael F. Insana +1 more
- Vol. 19, pp 516-528
TLDR
In this article, the authors used ultrasound to image viscoelastic features of tumors, which describe microenvironmental factors that stimulate signaling pathways in tumors that ultimately affect metastatic potential and response to traditional therapeutics.Abstract:
Recent advances in molecular biology are providing new opportunities for breast cancer imaging. Our approach uses ultrasound to image viscoelastic features of tumors. These features describe microenvironmental factors that stimulate signaling pathways in tumors that ultimately affect metastatic potential and response to traditional therapeutics. This paper explains the motivation for the approach, describes measurements in phantoms and patients, and defines measurement sensitivity using hydrogels with tissue-like features.read more
Citations
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Journal ArticleDOI
Viscoelasticity imaging using ultrasound: parameters and error analysis.
TL;DR: The focus of this paper is on imaging parameter estimation from ultrasonic echo data, and how jitter from hand-held force applicators used for clinical applications propagate through the imaging chain to generate image noise.
Journal ArticleDOI
A Robust Method to Estimate the Time Constant of Elastographic Parameters
TL;DR: Variable projection (VP) is proposed, a new technique named variable projection to estimate accurately and robustly the TC and steady-state value of the elastographic parameter of interest from its temporal curve that is robust to noise and capable of estimating the time constant with accuracy higher than that of typically employed curve-fitting techniques.
Posted Content
A spline interpolation based data reconstruction technique for estimation of strain time constant in ultrasound poroelastography
TL;DR: A cubic spline–based interpolation method, which allows to use only good quality strain frames (i.e., frames with sufficiently high signal-to-noise ratio [SNR]) to estimate the strain TC, and is of great help in applications relying on the accurate assessment of the temporal behavior of strain data.
Journal ArticleDOI
A Spline Interpolation–based Data Reconstruction Technique for Estimation of Strain Time Constant in Ultrasound Poroelastography:
TL;DR: In this article, a cost-effective and non-invasive imaging technique, which can be used to reconstruct mechanical parameters of tissues such as Young's modulus, Poisson's ratio, inters...
Proceedings ArticleDOI
4J-1 Towards a Molecular Level Understanding of Elasticity in Tissues and Hydrogels
TL;DR: In this article, the authors used low order discrete rheological models from linear viscoelastic theory to reduce data dimensionality yielding parameters related to stiffness and viscosity: elastic strain and two retardation time constants.
References
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Journal ArticleDOI
Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation.
TL;DR: Recent advances in understanding the paracrine signaling interactions between epithelial cancer cells and associated fibroblasts are summarized and the effects of these bidirectional interactions on various aspects of carcinoma formation are examined.
Journal ArticleDOI
High-resolution tensor MR elastography for breast tumour detection.
TL;DR: The analysis of the eigenvalues of the elasticity tensor support the hypothesis that breast carcinoma might exhibit an anisotropic elasticity distribution and the surrounding benign tissue appears isotropic.
Journal ArticleDOI
MRI of the tumor microenvironment.
TL;DR: This review attempts to identify techniques and their application to tumor biology, with an emphasis on nuclear magnetic resonance (NMR) approaches, using electron MR, optical, and radionuclear imaging techniques.
Journal ArticleDOI
Phantom materials for elastography
TL;DR: In this article, a device and procedure for measuring elastic properties of gelatin for elasticity imaging (elastography) was described. And the measured compression forces were comparable to results obtained from finite element analysis when linear elastic media are assumed.
Journal ArticleDOI
Structure and swelling of poly(acrylic acid) hydrogels: effect of pH, ionic strength, and dilution on the crosslinked polymer structure
TL;DR: In this article, the effect of pH on the formation of poly(acrylic acid) copolymers was investigated, and it was found that the amount of water present during the polymerization increases primary cyclization rates, and this change affects the subsequent swelling behavior of the acrylic acid hydrogel.