Journal ArticleDOI
Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus.
About:
This article is published in Arthritis & Rheumatism.The article was published on 1970-11-01. It has received 120 citations till now. The article focuses on the topics: Anti-SSA/Ro autoantibodies.read more
Citations
More filters
Book ChapterDOI
CHAPTER 3 – Immunological Tolerance
TL;DR: This chapter focuses on immunological tolerance, which involves the initiation of events, which lead to a productive executive cell, are accompanied and sometimes preceded by induction and expansion of various types of modulator and suppressor cells.
Journal Article
A quantitative light- and electron-microscopic study of type IV nuclear bodies in crescentic glomerulonephritis.
TL;DR: Type IV nuclear bodies were found in all renal biopsies obtained from 14 patients with crescentic glomerulonephritis and in 8 of 43 control patients studied by light and electron microscopy.
Incidence and correlation with lymphocytotoxic antibodies
TL;DR: Findings strengthen the hypothesis that both an environmental agent, possibly a virus, as well as the genetic response are important in the pathogenesis of SLE and family members may be a logical population in whom to search for specific antibodies.
Journal ArticleDOI
Antibodies Against Double‐stranded RNA in Patients with Rheumatoid Arthritis, Osteoarthrosis and Paget's Disease of Bone
TL;DR: Using a liquid phase radioimmunoassay to detect antibodies to 3H-labelled double-stranded RNA the premise that rheumatoid arthritis and Paget's disease of the bone may be associated with a chronic virus disease was examined.
Journal ArticleDOI
Spontaneous endometrial deposition of immune complexes in aging NZB/WF1 mice: possible role of oncornavirus antigens.
TL;DR: Findings suggest that oncornavirus antigen-antibody complexes can be responsible for these uterine lesions, which are age dependent, being absent at 2 months and well established at 1 year.
References
More filters
Journal ArticleDOI
Defective Viral Particles and Viral Disease Processes
Alice S. Huang,David Baltimore +1 more
TL;DR: Preparations of many different types of viruses contain defective particles which consist of viral structural proteins and a part of the viral genome and may play a major part in the evolution of viral diseases.
Book ChapterDOI
The immunology and pathology of nzb mice.
J. B. Howie,B J Helyer +1 more
TL;DR: This chapter discusses the New Zealand Black (NZB) strain of mice that has attracted the attention of investigators throughout the world as an experimental model for human connective tissue disease and describes the patterns of development of the disease processes in the two groups of mice.
Journal ArticleDOI
Pathogenesis of the glomerulonephritis of nzb/w mice
P. H. Lambert,Frank J. Dixon +1 more
TL;DR: Enhancement of the antinuclear antibody response by active immunization of young NZB/W mice with DNA-methylated BSA hastens the development and increases the severity of the glomerulonephritis.
Journal ArticleDOI
The development of malignant lymphoma in the course of Sjögren's syndrome
Norman Talal,Joseph J. Bunim +1 more
TL;DR: The hypothesis is presented that in Sjogren's syndrome the chronic state of immunologic hyperactivity and the proliferation of immunologically competent cells producing abnormal tissue antibodies predispose to the relatively frequent development of malignant lymphoma.
Journal ArticleDOI
Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice.
TL;DR: The transfer of anti-LCM antibody to SWR/J carrier mice results in acute necrotizing inflammatory lesions in regions of viral persistence, followed by chronic mononuclear infiltrates quite similar to those seen after the transfer of immune cells.