Journal ArticleDOI
Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus.
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This article is published in Arthritis & Rheumatism.The article was published on 1970-11-01. It has received 120 citations till now. The article focuses on the topics: Anti-SSA/Ro autoantibodies.read more
Citations
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Journal ArticleDOI
Measles antibodies in sera from patients with autoimmune diseases.
TL;DR: Increased titres to measles virus were found in sera containing antibodies to thyroid, gastric, skeletal, and smooth muscle tissue and to mitochondria, as compared with sera from controls matched for sex and age.
Journal ArticleDOI
Selective depletion of Ig-bearing lymphocytes by cyclophosphamide in rheumatoid arthritis and systemic lupus erythematosu guidelines for dosage
TL;DR: Direct quantitation of B-lymphocytes may be helpful in regulating clinically effective individual doses of cyclophosphamide in a manner that is relatively safe and a reduction of other leukocytes is not necessary for a favorable clinical response.
Journal ArticleDOI
Comparison of therapeutic and immunosuppressive effects of azathioprine, prednisolone and combined therapy in NZP-NZW mice.
TL;DR: Combined therapy was superior to either drug used alone, and the immunosuppressive effect of greatest clinical importance seemed to be the ability to prevent formation of anti-DNA antibodies.
Journal ArticleDOI
Pathogenetic mechanisms of interstitial pulmonary fibrosis in patients with serum antinuclear factor: A histologic and clinical correlation☆
Hiroshi Nagaya,Herbert O. Sieker +1 more
TL;DR: The histologic findings suggest that the pulmonary lesions in six patients with idiopathic interstitial pulmonary fibrosis resulted from immune reactions to some agents not unlike those seen in systemic lupus erythematosus.
References
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Journal ArticleDOI
Defective Viral Particles and Viral Disease Processes
Alice S. Huang,David Baltimore +1 more
TL;DR: Preparations of many different types of viruses contain defective particles which consist of viral structural proteins and a part of the viral genome and may play a major part in the evolution of viral diseases.
Book ChapterDOI
The immunology and pathology of nzb mice.
J. B. Howie,B J Helyer +1 more
TL;DR: This chapter discusses the New Zealand Black (NZB) strain of mice that has attracted the attention of investigators throughout the world as an experimental model for human connective tissue disease and describes the patterns of development of the disease processes in the two groups of mice.
Journal ArticleDOI
Pathogenesis of the glomerulonephritis of nzb/w mice
P. H. Lambert,Frank J. Dixon +1 more
TL;DR: Enhancement of the antinuclear antibody response by active immunization of young NZB/W mice with DNA-methylated BSA hastens the development and increases the severity of the glomerulonephritis.
Journal ArticleDOI
The development of malignant lymphoma in the course of Sjögren's syndrome
Norman Talal,Joseph J. Bunim +1 more
TL;DR: The hypothesis is presented that in Sjogren's syndrome the chronic state of immunologic hyperactivity and the proliferation of immunologically competent cells producing abnormal tissue antibodies predispose to the relatively frequent development of malignant lymphoma.
Journal ArticleDOI
Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice.
TL;DR: The transfer of anti-LCM antibody to SWR/J carrier mice results in acute necrotizing inflammatory lesions in regions of viral persistence, followed by chronic mononuclear infiltrates quite similar to those seen after the transfer of immune cells.