Journal ArticleDOI
Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus.
About:
This article is published in Arthritis & Rheumatism.The article was published on 1970-11-01. It has received 120 citations till now. The article focuses on the topics: Anti-SSA/Ro autoantibodies.read more
Citations
More filters
Journal ArticleDOI
Mixed connective tissue disease-an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA)
TL;DR: The detection of antibody to ENA with a well defined specificity allows recognition of an apparently distinct mixed connective tissue disease syndrome which is characterized by an excellent response to corticosteroid therapy and a favorable prognosis.
Book ChapterDOI
Murine models of systemic lupus erythematosus.
TL;DR: This chapter reviews the histopathologic, serologic, lymphocytic, virological, hormonal, and genetic characteristics of murine models of systemic lupus erythematosus (SLE) to support the statement that the final immunopathologic perturbation in murine (and human) SLE is a B lymphocyte hyperactivity with corresponding enhancement of serum antibodies and autoantibodies, particularly IgG.
Journal ArticleDOI
Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in nzb/nzw f1 mice.
TL;DR: Mice receiving androgen showed improved survival, reduced anti-nucleic acid antibodies, or less evidence of glomerulonephritis as determined by light, immunofluorescent, and electron microscopy, while opposite effects were observed in castrated mice receiving estrogen.
Book ChapterDOI
Immune Complex Disease in Experimental Animals and Man
Charles G. Cochrane,D Koffler +1 more
TL;DR: This chapter summarizes the data presented in two reviews of experimental acute and chronic immune complex disease produced by nonliving antigens and discusses in detail more recent studies.
Journal Article
The spectrum of benign to malignant lymphoproliferation in Sjögren's syndrome
L G Anderson,N Talal +1 more
TL;DR: In Sjogren's syndrome, as in these other conditions, it seems likely that a combination of genetic, immunologic, and viral or other unknown environmental factors plays a role in pathogenesis.
References
More filters
Journal Article
The pathogenesis of autoimmunity in New Zealand mice. II. Acceleration of glomerulonephritis by polyinosinic-polycytidylic acid.
Journal ArticleDOI
Immunochemical measurement of double-stranded RNA of uninfected and arbovirus-infected mammalian cells.
Victor Stollar,B. David Stollar +1 more
TL;DR: All classes of this RNA detected immunochemically showed a sharp thermal denaturation curve, and increased in amount progressively during infection, with the 12S peak predominant at all times.
Journal ArticleDOI
Immune Response to a Soluble Protein Antigen in NZB Mice
TL;DR: MICE of the NZB strain spontaneously develop autoimmune haemolytic anaemia and their sera contain various antibodies reactive with autologous and even heterologous red cells, although in older animals splenomegaly is chiefly caused by proliferation of erythropoietic tissue3.
Journal ArticleDOI
COMPARISON OF THE IMMUNE RESPONSIVENESS OF NZB AND NZB x NZW F1 HYBRID MICE WITH THAT OF OTHER STRAINS OF MICE
TL;DR: The results do not support the concept that NZB/W mice possess a general immune hyperreactivity or a relative inability to be made tolerant to protein antigens, but they do not rule out the possibility that these mice have a genetically determined hyperresponsiveness to some antIGens, in particular to nuclear antigen.
Journal ArticleDOI
Wide distribution of leukaemia virus in strains of laboratory mice.
Masahiro Kajima,Morris Pollard +1 more
TL;DR: Additional conventional mouse strains for leukaemia virus are examined by electron microscopy and some also for host-response to the leukaemogenic action of whole-body irradiation and for development of a virus-free mouse strain.