Journal ArticleDOI
Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus.
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This article is published in Arthritis & Rheumatism.The article was published on 1970-11-01. It has received 120 citations till now. The article focuses on the topics: Anti-SSA/Ro autoantibodies.read more
Citations
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Journal ArticleDOI
Impaired delayed hypersensitivity in systemic lupus erythematosus.
TL;DR: When identical twin sisters discordant for systemic lupus erythematosus (SLE) were immunized with keyhole limpet hemocyanin (KLH) the affected twin failed to develop delayed hypersensitivity and her lymphocytes failed to proliferate in response to KLH in vitro, unlike her normal sister.
Journal ArticleDOI
Prostaglandin E1 treatment of NZB/NZW F1 hybrid mice. II. Prevention of glomerulonephritis.
TL;DR: The F1 hybrid of New Zealand black and New Zealand white mice (NZB/NZW mice) developed a disease similar to human systemic lupus erythematous, characterized by impaired cell-mediated and enhanced humoral immune responses, development of antibodies to nuclear antigens, and immune complex glomerulonephritis.
Journal ArticleDOI
Disordered Immunologic Regulation and Autoimmunity
TL;DR: Autoimmunity, whether manifest by B lymphocytes producing autoantibodies or by T lymphocytes and macrophages infiltrating and destroying target organs, may arise not as a primary effector-cell abnormality, but rather as the consequence of disordered immunologic control.
Journal ArticleDOI
Viruses and the connective tissue diseases.
TL;DR: The role of virus infection in multisystem disease of man is examined, using evidence from patients and animal models, and in New Zealand Black mice and their F1hybrid NZB-NZW strain, leukemog...
References
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Journal ArticleDOI
Defective Viral Particles and Viral Disease Processes
Alice S. Huang,David Baltimore +1 more
TL;DR: Preparations of many different types of viruses contain defective particles which consist of viral structural proteins and a part of the viral genome and may play a major part in the evolution of viral diseases.
Book ChapterDOI
The immunology and pathology of nzb mice.
J. B. Howie,B J Helyer +1 more
TL;DR: This chapter discusses the New Zealand Black (NZB) strain of mice that has attracted the attention of investigators throughout the world as an experimental model for human connective tissue disease and describes the patterns of development of the disease processes in the two groups of mice.
Journal ArticleDOI
Pathogenesis of the glomerulonephritis of nzb/w mice
P. H. Lambert,Frank J. Dixon +1 more
TL;DR: Enhancement of the antinuclear antibody response by active immunization of young NZB/W mice with DNA-methylated BSA hastens the development and increases the severity of the glomerulonephritis.
Journal ArticleDOI
The development of malignant lymphoma in the course of Sjögren's syndrome
Norman Talal,Joseph J. Bunim +1 more
TL;DR: The hypothesis is presented that in Sjogren's syndrome the chronic state of immunologic hyperactivity and the proliferation of immunologically competent cells producing abnormal tissue antibodies predispose to the relatively frequent development of malignant lymphoma.
Journal ArticleDOI
Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice.
TL;DR: The transfer of anti-LCM antibody to SWR/J carrier mice results in acute necrotizing inflammatory lesions in regions of viral persistence, followed by chronic mononuclear infiltrates quite similar to those seen after the transfer of immune cells.