Journal ArticleDOI
Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus.
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This article is published in Arthritis & Rheumatism.The article was published on 1970-11-01. It has received 120 citations till now. The article focuses on the topics: Anti-SSA/Ro autoantibodies.read more
Citations
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Journal ArticleDOI
Androgenic Hormones Modulate Autoantibody Responses and Improve Survival in Murine Lupus
TL;DR: The results suggest that sex hormones modulate immunologic regulation and that androgenic hormones are protective in murine lupus.
Book ChapterDOI
The pathogenesis of autoimmunity in New Zealand black mice.
Norman Talal,Alfred D. Steinberg +1 more
TL;DR: An attempt will be made to relate these immunological abnormalities of New Zealand Black and NZB/NZW mice with genetic and viral factors known to be important in their disease processes.
Journal ArticleDOI
Hematologic Aspects of Systemic Lupus Erythematosus: Current Concepts
TL;DR: Most clinically significant hematopoietic abnormalities can be suppressed by corticosteroids; however, splenectomy, or immunosuppressive agents, or both, may be indicated for patients who respond inadequately to cortICosteroids.
Journal ArticleDOI
Guillain-Barré syndrome and Hodgkin's disease: three cases with immunological studies.
TL;DR: GBS is reported in 3 patients with Hodgkin's disease and it is suggested that under certain circumstances, partial and perhaps transient immunosuppression could serve as one contributing factor in triggering an autoimmune disease of the PNS.
Journal ArticleDOI
Induction of suppressor T cells in systemic lupus erythematosus by thymosin and cultured thymic epithelium.
TL;DR: Thymic manipulation may be a useful therapeutic modality in this disease and suppression cell activity was induced by incubation with thymosin or cultured thymic epithelium.
References
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Journal ArticleDOI
Defective Viral Particles and Viral Disease Processes
Alice S. Huang,David Baltimore +1 more
TL;DR: Preparations of many different types of viruses contain defective particles which consist of viral structural proteins and a part of the viral genome and may play a major part in the evolution of viral diseases.
Book ChapterDOI
The immunology and pathology of nzb mice.
J. B. Howie,B J Helyer +1 more
TL;DR: This chapter discusses the New Zealand Black (NZB) strain of mice that has attracted the attention of investigators throughout the world as an experimental model for human connective tissue disease and describes the patterns of development of the disease processes in the two groups of mice.
Journal ArticleDOI
Pathogenesis of the glomerulonephritis of nzb/w mice
P. H. Lambert,Frank J. Dixon +1 more
TL;DR: Enhancement of the antinuclear antibody response by active immunization of young NZB/W mice with DNA-methylated BSA hastens the development and increases the severity of the glomerulonephritis.
Journal ArticleDOI
The development of malignant lymphoma in the course of Sjögren's syndrome
Norman Talal,Joseph J. Bunim +1 more
TL;DR: The hypothesis is presented that in Sjogren's syndrome the chronic state of immunologic hyperactivity and the proliferation of immunologically competent cells producing abnormal tissue antibodies predispose to the relatively frequent development of malignant lymphoma.
Journal ArticleDOI
Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice.
TL;DR: The transfer of anti-LCM antibody to SWR/J carrier mice results in acute necrotizing inflammatory lesions in regions of viral persistence, followed by chronic mononuclear infiltrates quite similar to those seen after the transfer of immune cells.